Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Shabby Pop-Sci Article on the Minicircle Trial of Follistatin Gene Therapy
Minicircle is working towards the upregulation of follistatin, an inhibitor of myostatin and thus an interesting target for improved muscle growth and treatment of sarcopenia. Follistatin and myostatin are well studied genes in this context, and there are any number of animal studies, as well as human trials of various approaches to myostatin inhibition. As I have long said, follistatin and myostatin are probably the most compelling, least risky genes to start working on if interested in gene therapy development. There is a great deal of animal and human data to support this work.
It is always annoying to see shabbi...
Source: Fight Aging! - February 14, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
High Blood Pressure and Erectile Dysfunction
Research confirms that high blood pressure and ED are closely linked. But did you know the majority of cases of ED are caused by hypertension? Keep reading to find out more.
Experts suggest that “hypertension is sometimes a standalone condition and sometimes it’s associated with other conditions, which also impact erectile dysfunction.”
According to the European Society of Cardiology, this likelihood is almost double in men with uncontrolled high blood pressure.
Long-term exposure to hypertension and elevated blood pressure damages the arterial wall. This leads to atherosclerosis and the narrowing of art...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Against Testosterone Treatments for Older People
This cutting opinion piece is written in opposition to the prevalence of testosterone therapy, offered in many cases with the (dubious) promise of it being a way to push back the advance of aging. Hormone therapies in general are not to be taken lightly, but are widely used. Anyone should be free to try whatever they feel may work for them, but this approach may not be justified for most people given the balance of risk and benefit. That isn't a justification for restriction of personal freedom, but rather for greater efforts to educate in the face of overly enthusiastic marketing.
It is not easy in the present en...
Source: Fight Aging! - February 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease.
Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
https://www.fightaging.org/archives/2020/04/notes-on-self-experi...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
I periodically publish thoughts on self-experiments that seem interesting and relevant to aging. Despite the influence of the quantified self movement, the broader self-experimentation community is largely terrible on matters of research, rigor, reporting, and safety. My motivation is to something to raise the bar on all of these items.
For every discussion I've published on a particular self-experiment, there are half a dozen others sitting at some stage of research and interest. Over the past year or so, I've been on and off looking into sex steroid ablation as a mechanism for thymus regrowth. Since my company, Re...
Source: Fight Aging! - April 30, 2020 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Inside Schizophrenia: Schizophrenia in Men
Men and women experience schizophrenia differently; from the age of onset to symptoms and how society treats those with mental disorders.
Schizophrenic, Rachel Star Withers and co-host Gabe Howard continue the discussion of the differences from the last episode but change the focus to men.
Jason Jepson, an author who has schizophrenia joins for a man’s perspective and Dr. Hayden Finch returns to explain the clinical side of the issues.
Highlights in “Schizophrenia in Men” Episode
[01:30] Age of onset
[04:00] Symptoms in men vs women
[05:00] Interview with Jason Jepson
[07:30] Jason discusses homelessness
[10:00...
Source: World of Psychology - March 18, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Inside Schizophrenia Men's Issues Psychiatry Psychology Living With Schizophrenia Mental Disorder Mental Health Mental Illness Symptoms Of Schizophrenia Source Type: blogs
Testosterone Increases The Aggressiveness Of Some Men More Than Others, Depending On Their Personality And Genes
In this study, the researchers considered men who scored higher for dominance, higher for “independent self-construal” (which involves defining yourself in terms of internal attributes, such as traits, rather than in terms of relationships with others), and lower for self-control, as having high “personality risk” for the dose of testosterone making them more aggressive – and this is what they found
However, this personality effect was even stronger for the more than 200 men in the sample whose DNA analysis showed that they have a variation of the androgen receptor gene (that codes for the receptor that testoster...
Source: BPS RESEARCH DIGEST - March 26, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: biological Genetics Source Type: blogs
Man Boobs, Muffin Tops and Bagel Bumps
Muffin tops, man boobs, and bagel bumps: These are among the varied and perverse ways that the hormonal distortions inflicted on unwitting humans who consume the seeds of grasses, i.e., grains, show themselves.
In our modern world filled with thousands of processed foods, there are plenty of landmines for health. Gummy bears and gumdrops will rot teeth, for instance. Indulge in a handful of dried prunes and you’ll have to schedule a substantial portion of your day on the toilet due to bowel irritants.
But only wheat and grains are associated with a wide swath of health problems that range from autoimmune disease to m...
Source: Wheat Belly Blog - March 4, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates grain-free gynecomastia man boobs man breasts testosterone undoctored wheat belly Source Type: blogs
Is wheat really THAT bad?
Because it has become such a frequent item in everyday meals, suggesting that something so commonplace must be fine, people often ask: Is wheat really that bad?
Let’s therefore catalog the health conditions that are associated with wheat consumption.
Health conditions we know with 100% certainty are caused by consumption of wheat and related grains:
Celiac disease, dermatitis herpetiformis, cerebellar ataxia, “idiopathic” peripheral neuropathy, temporal lobe seizures, gluten encephalopathy, type 1 diabetes, rheumatoid arthritis, autoimmune hepatitis, autoimmune pancreatitis, tooth decay
Health conditions ...
Source: Wheat Belly Blog - March 2, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune diabetes gluten-free grain-free grains wheat wheat belly Source Type: blogs
What Do I Do When My Antidepressant Stops Working?
This study examined 103 patients with bipolar 1 disorder who, despite taking a mood stabilizer, experienced frequent relapses. During a 12-month period, the group receiving cognitive therapy had significantly fewer bipolar episodes and reported less mood symptoms on the monthly mood questionnaires. They also had less fluctuation in manic symptoms.
It’s normal to panic in the days and weeks your symptoms return; however, as you can see, there are many options to pursue. If the first approach doesn’t work, try another. Persevere until you achieve full remission and feel like yourself again. It will happen. Trust me on th...
Source: World of Psychology - March 1, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Antidepressant Bipolar Depression General Medications Manic Episode Mood Disorder Mood Stabilizer Relapse Source Type: blogs
The REAL Story Behind Man Breasts (And How to Get Rid of Them)
Abnormal breast enlargement in a male, gynecomastia, is a common sign of distorted hormonal status triggered by visceral fat, i.e., inflammatory fat housed in the abdomen that converts a male’s testosterone to estrogen. “Love handles” therefore nearly always accompany man breasts.
In addition, consumption of wheat and related grains yields something called the A5 pentapeptide that provokes hypothalamic release of prolactin: pro-lactation, i.e., it prepares the breast for breast feeding.
These are vivid illustrations of just how far wrong the American diet has gone. It is caused by diet, it can be revers...
Source: Wheat Belly Blog - February 23, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates a5 pentapeptide estrogen Gliadin gynecomastia Inflammation low testosterone man boobs man breasts Weight Loss wheat belly Wheat Belly Total Health Source Type: blogs
Mr. and Mrs. Wheat Belly
Men and women follow the Wheat Belly lifestyle and can undergo important and sometime startling hormonal changes. Though results vary with stage of life—young adults, middle-aged, older—there are a variety of hormonal changes that women and men typically experience, some in concert, others independently. Such hormonal shifts can be powerful and part of the health-restoring menu of changes that develop with this lifestyle. They can even improve a relationship in a number of ways, both physically and emotionally, especially if we weave in some of the newer Wheat Belly/Undoctored concepts and practices such as oxy...
Source: Wheat Belly Blog - March 13, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle estradiol estrogen hormonal hormones Inflammation low-carb oxytocin testosterone Thyroid Weight Loss Source Type: blogs
Lactobacillus reuteri: Key to youthfulness?
Microbial species in the genus Lactobacillus, found in the human intestine as well as in fermented foods like yogurt and kefir, are known to provide health benefits to us. A number of important health benefits have been associated with increased populations of intestinal Lactobacillus, such as protection from fungal/Candidal overgrowth and vaginitis, reduction of the dysbiosis of irritable bowel syndrome/small intestinal bacterial overgrowth, and reduced unhealthy oral bacteria (e.g., Streptococcus mutans) that cause cavities.
Of the nearly 200 known species of Lactobacillus, however, one species is beginning to stand out:...
Source: Wheat Belly Blog - January 3, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle anti-aging bowel flora Dr. Davis grain-free grains health healthcare reuteri testosterone Source Type: blogs
