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Medical News Today: Low oxygen reverses neurodegenerative disease in mice
A new study shows that continuous treatment with hypoxia protects mice's brain from lesions typical of Leigh syndrome and can reverse existing damage. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 9, 2017 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Low oxygen reverses mitochondrial disease in mice
Hypoxia reverses brain damage caused by mitochondrial dysfunction, a team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 8, 2017 Category: Science Source Type: news

Head trauma as a precipitating factor for late-onset Leigh syndrome: a case report - Ashrafi F, Pakdaman H, Arabahmadi M, Behnam B.
Leigh syndrome is a severe progressive neurodegenerative disorder with different clinical presentationsthat usually becomes apparent in the first year of life and rarely in late childhood and elderly years. It is causedby failure of mitochondrial respirato... (Source: SafetyLit)
Source: SafetyLit - March 15, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The Newborn In The News Is Not The First '3 Person Baby,' But His Birth Is Still Revolutionary
A new twist on a fertility procedure allowed three people to contribute DNA to a healthy boy born to a Jordanian couple on April 6.  While the child is actually not the world’s “first three-person baby,” as many news outlets have reported, he is the first healthy baby born using a new technique that doesn’t require the destruction of an embryo, according to New Scientist.  As Buzzfeed reported, dozens of so-called three-person babies have been born since the 1990s. The three-parent method is tried when a parent does not want to pass down a genetic mutation; in this case, the...
Source: Science - The Huffington Post - September 29, 2016 Category: Science Source Type: news

World ’s First Baby Born With DNA From Three Parents
In a world first, a baby has been born with DNA from three biological parents. Five-month-old Abrahim Hassan’s Jordanian parents, Ibtisam Shaban and Mahmoud Hassan, were treated by a U.S. team based in Mexico using a controversial technique that allows parents with rare genetic mutations to have healthy babies, the New Scientist reports. Shaban carries genes for Leigh syndrome, a rare genetic disorder characterized by the degeneration of the central nervous system; the brain, spinal cord, and optic nerve. Although she is healthy, Shaban’s first two children died because of Leigh syndrome, so she sought out the...
Source: TIME.com: Top Science and Health Stories - September 27, 2016 Category: Consumer Health News Authors: Kate Samuelson Tags: Uncategorized DNA fertility IVF maternity Source Type: news

[Research Article] Hypoxia as a therapy for mitochondrial disease
Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability. Genetic or small-molecule activation of the hypoxia response is protective against mitochondrial toxicity in cultured cells and zebrafish models. Chronic hypoxia leads to a marked improvement in survival, body weight, body temperature, behavior, neu...
Source: ScienceNOW - March 31, 2016 Category: Science Authors: Isha H. Jain Source Type: news

Our story: 'Why three-parent babies would give our family hope'
Vicky Holliday and Keith Newell, whose daughter Jessica was born with Leigh Syndrome due to faulty mitochondria, say allowing three-parent babies would enable them, and other families, to think about having more children (Source: Telegraph Health)
Source: Telegraph Health - February 3, 2015 Category: Consumer Health News Tags: child IVF Leigh DNA baby mitochondria pregnant fertility parent Syndrome Source Type: news

'It is imperative we stop this cruel disease being passed on'
Victoria Holliday urges MPs to support a procedure that could allow her and others to have healthy children (Source: Telegraph Health)
Source: Telegraph Health - October 22, 2014 Category: Consumer Health News Tags: leigh syndrome children's health house of commons Source Type: news

Edison’s Vatiquinone receives FDA orphan drug status for Leigh syndrome
Inherited mitochondrial disease treatment specialists Edison Pharmaceuticals has received orphan drug designation from the US Food and Drug Administration (FDA) for its vatiquinone to treat Leigh syndrome. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - June 9, 2014 Category: Pharmaceuticals Source Type: news

Japanese Ministry grants orphan status to Edison's EPI-743 to treat Leigh syndrome
The Japanese Ministry of Health, Labour and Welfare (MHLW) has granted orphan designation to Edison Pharmaceuticals' EPI-743, an orally bioavailable small molecule, being developed for the treatment of Leigh syndrome in children. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - May 21, 2014 Category: Pharmaceuticals Source Type: news

Leigh's Disease (Leigh's Syndrome)
Title: Leigh's Disease (Leigh's Syndrome)Category: Diseases and ConditionsCreated: 4/25/2011 2:10:00 PMLast Editorial Review: 4/2/2014 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - April 2, 2014 Category: Pediatrics Source Type: news

Consultation on babies with three people's DNA
Controversial technique, currently banned, would prevent women from passing mitochondrial diseases to their childrenThe Department of Health has launched a three-month consultation on the draft regulations for a radical procedure that aims to prevent mothers from passing on serious genetic diseases to their children, a controversial technique because it leads to babies with DNA from three people.Mitochondrial transfer has never been tried in humans and is prohibited in Britain under laws that ban the placing of an egg or embyro into a woman if the DNA has been altered. But scientists working on the technique said it offere...
Source: Guardian Unlimited Science - February 27, 2014 Category: Science Authors: Ian Sample Tags: Reproduction Genetics Human biology Medical research Controversies Science Embryos Health Society The Guardian News Source Type: news

Consultation on technique to prevent mitochondrial disease launched in UK
Controversial technique, currently banned, would prevent women from passing mitochondrial diseases to their childrenThe Department of Health has launched a three-month consultation on the draft regulations for a radical procedure that aims to prevent mothers from passing on serious genetic diseases to their children, a controversial technique because it leads to babies with DNA from three people.Mitochondrial transfer has never been tried in humans and is prohibited in Britain under laws that ban the placing of an egg or embyro into a woman if the DNA has been altered. But scientists working on the technique said it offere...
Source: Guardian Unlimited Science - February 27, 2014 Category: Science Authors: Ian Sample Tags: Embryos theguardian.com Genetics Biology News Health Medical research Human biology Society Reproduction Science Source Type: news

Fatal mitochondrial defect treated with FDA approved immune-modulating drug
The transplant anti-rejection drug rapamycin showed unexpected benefits in a mouse model of a fatal defect in the energy powerhouses of cells, the mitochondria. Children with the condition, Leigh syndrome, show progressive brain damage, muscle weakness, lack of coordination or muscle control, and weight loss, and usually succumb to respiratory failure.Leigh syndrome is often diagnosed within the first year of life. Affected children rarely survive beyond 6 or 7 years. At present, the disorder, which can result from several different underlying causes, has no effective treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news