What Is the Lifespan of People With Leigh Syndrome?
Title: What Is the Lifespan of People With Leigh Syndrome?Category: Diseases and ConditionsCreated: 9/22/2021 12:00:00 AMLast Editorial Review: 9/22/2021 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - September 22, 2021 Category: Pediatrics Source Type: news

Boy, 6, with rare neurological disorder denied experimental medicine that could extend his life 
Timothy Donohue, six, from Jacksonville, Florida, was diagnosed with Leigh's syndrome, a rare, neurodegenerative disorder that affects the mitochondria in February 2016. (Source: the Mail online | Health)
Source: the Mail online | Health - March 12, 2019 Category: Consumer Health News Source Type: news

New mouse model reminiscent of Leigh syndrome sheds light on mechanisms of neurodegeneration
(VIB (the Flanders Institute for Biotechnology)) Leuven researchers led by professor Bart De Strooper (VIB-KU Leuven) have identified a new role for PARL, a protein that has been linked to Parkinson's disease. In this week's edition of the Proceedings of the National Academy of Science, they report that mice lacking PARL display specific problems in the nervous system reminiscent of Leigh syndrome instead. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 2, 2019 Category: International Medicine & Public Health Source Type: news

Heartbroken parents will one day bury their fourth child
Adele and Craig Lake, from Grimsby, have already lost three children to Leigh syndrome, which causes fatal brain and nerve damage, and their last remaining child, Jade, also has the condition. (Source: the Mail online | Health)
Source: the Mail online | Health - December 27, 2018 Category: Consumer Health News Source Type: news

Ashkenazi Jewish founder mutation identified for Leigh Syndrome
(Children's Hospital of Philadelphia) Decades after two brothers died in childhood of a mitochondrial disease, researchers pinpointed the exact cause in a founder mutation among Ashkenazi Jews. The discoverers say the mutation should be added to prenatal carrier screening programs for prospective parents. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2018 Category: International Medicine & Public Health Source Type: news

Doctors race to save six-year-old from rare neurological disorder
Will Woleben, six, from McKinney, Texas, was diagnosed with Leigh syndrome in April 2014. Now his parents are working to raise $300,000 to enroll him in a gene therapy trial. (Source: the Mail online | Health)
Source: the Mail online | Health - August 16, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Low oxygen reverses neurodegenerative disease in mice
A new study shows that continuous treatment with hypoxia protects mice's brain from lesions typical of Leigh syndrome and can reverse existing damage. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 9, 2017 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Low oxygen reverses mitochondrial disease in mice
Hypoxia reverses brain damage caused by mitochondrial dysfunction, a team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 8, 2017 Category: Science Source Type: news

Head trauma as a precipitating factor for late-onset Leigh syndrome: a case report - Ashrafi F, Pakdaman H, Arabahmadi M, Behnam B.
Leigh syndrome is a severe progressive neurodegenerative disorder with different clinical presentationsthat usually becomes apparent in the first year of life and rarely in late childhood and elderly years. It is causedby failure of mitochondrial respirato... (Source: SafetyLit)
Source: SafetyLit - March 15, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The Newborn In The News Is Not The First '3 Person Baby,' But His Birth Is Still Revolutionary
A new twist on a fertility procedure allowed three people to contribute DNA to a healthy boy born to a Jordanian couple on April 6.  While the child is actually not the world’s “first three-person baby,” as many news outlets have reported, he is the first healthy baby born using a new technique that doesn’t require the destruction of an embryo, according to New Scientist.  As Buzzfeed reported, dozens of so-called three-person babies have been born since the 1990s. The three-parent method is tried when a parent does not want to pass down a genetic mutation; in this case, the...
Source: Science - The Huffington Post - September 29, 2016 Category: Science Source Type: news

World ’s First Baby Born With DNA From Three Parents
In a world first, a baby has been born with DNA from three biological parents. Five-month-old Abrahim Hassan’s Jordanian parents, Ibtisam Shaban and Mahmoud Hassan, were treated by a U.S. team based in Mexico using a controversial technique that allows parents with rare genetic mutations to have healthy babies, the New Scientist reports. Shaban carries genes for Leigh syndrome, a rare genetic disorder characterized by the degeneration of the central nervous system; the brain, spinal cord, and optic nerve. Although she is healthy, Shaban’s first two children died because of Leigh syndrome, so she sought out the...
Source: TIME.com: Top Science and Health Stories - September 27, 2016 Category: Consumer Health News Authors: Kate Samuelson Tags: Uncategorized DNA fertility IVF maternity Source Type: news

[Research Article] Hypoxia as a therapy for mitochondrial disease
Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability. Genetic or small-molecule activation of the hypoxia response is protective against mitochondrial toxicity in cultured cells and zebrafish models. Chronic hypoxia leads to a marked improvement in survival, body weight, body temperature, behavior, neu...
Source: ScienceNOW - March 31, 2016 Category: Science Authors: Isha H. Jain Source Type: news

Our story: 'Why three-parent babies would give our family hope'
Vicky Holliday and Keith Newell, whose daughter Jessica was born with Leigh Syndrome due to faulty mitochondria, say allowing three-parent babies would enable them, and other families, to think about having more children (Source: Telegraph Health)
Source: Telegraph Health - February 3, 2015 Category: Consumer Health News Tags: child IVF Leigh DNA baby mitochondria pregnant fertility parent Syndrome Source Type: news

'It is imperative we stop this cruel disease being passed on'
Victoria Holliday urges MPs to support a procedure that could allow her and others to have healthy children (Source: Telegraph Health)
Source: Telegraph Health - October 22, 2014 Category: Consumer Health News Tags: leigh syndrome children's health house of commons Source Type: news