FLARE: Favipiravir +/- Lopinavir: A RCT of Early Antivirals
Condition: COVID-19 Interventions: Drug: Favipiravir; Drug: Lopinavir/ Ritonavir; Other: Favipiravir Placebo; Other: Lopinavir/ Ritonavir Placebo Sponsors: University College, London; LifeArc Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 5, 2020 Category: Research Source Type: clinical trials
The Australasian COVID-19 Trial (ASCOT) to assess clinical outcomes in hospitalised patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesTo determine if lopinavir/ritonavir +/- hydroxychloroquine will reduce the proportion of participants who survive without requiring ventilatory support, 15 days after enrolment, in adult participants with non-critically ill SARS-CoV-2 infection.Trial designASCOT is an investigator-initiated, multi-centre, open-label, randomised controlled trial. Participants will have been hospitalised with confirmed COVID-19, and will be randomised 1:1:1:1 to receive lopinavir /ritonavir, hydroxychloroquine, both or neither drug in addition to standard of care management.ParticipantsParticipants will be recruited from>...
Source: Trials - July 13, 2020 Category: Research Source Type: clinical trials
Combination Therapies to Reduce Carriage of SARS-Cov-2 and Improve Outcome of COVID-19 in Ivory Coast: a Phase Randomized IIb Trial
Conditions: COVID-19; COVID-19 Drug Treatment; Severe Acute Respiratory Syndrome Coronavirus 2 Interventions: Drug: Lopinavir/Ritonavir 200 MG-50 MG Oral Tablet; Drug: Telmisartan 40Mg Oral Tablet; Drug: Atorvastatin 20 Mg Oral Tablet Sponsors: French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS); Université de Bordeaux; Programme PACCI Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 10, 2020 Category: Research Source Type: clinical trials
