Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection - a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trial
AbstractObjectives1. To compare the safety and efficacy of Hydroxychloroquine with Ribavirin and standard treatment in patients with non-severe COVID-19 infection2. To compare the safety and efficacy of standard treatment, Lopinavir-ritonavir with Ribavarin, and Hydroxychloroquine with Ribavirin in patients with severe COVID-19 infectionTrial designThe study is an Open label, Parallel arm design, stratified randomised controlled trial. Patients will be categorised as non-severe or severe based on predefined criteria. Those who satisfy all inclusion criteria and no exclusion criteria in the respective categories, will be ra...
Source: Trials - October 20, 2020 Category: Research Source Type: clinical trials
the Investigation Into Beneficial Effects of High-dose Interferon Beta 1-a, Compared to Low-dose Interferon Beta 1-a in Moderate to Severe Covid-19
Condition: Covid19 Interventions: Drug: High dose Interferon-beta 1a; Drug: Lopinavir/Ritonavir; Drug: Low dose Interferon-beta 1a Sponsor: Shahid Beheshti University of Medical Sciences Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 20, 2020 Category: Research Source Type: clinical trials
Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum
Conditions: HIV Infections; Tuberculosis Interventions: Drug: Bictegravir (BIC); Drug: Tenofovir alafenamide (TAF); Drug: Cabotegravir (CAB); Drug: Dolutegravir (DTG); Drug: Atazanavir/ritonavir (ATV/r); Drug: Darunavir/ritonavir (DRV/r); Drug: Lopinavir/ritonavir (LPV/r); Drug: Cobicistat; Drug: Ritonavir; Drug: First-Line TB Treatment; Drug: Second-Line TB Treatment; Drug: Doravirine (DOR) Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network; E...
Source: ClinicalTrials.gov - August 19, 2020 Category: Research Source Type: clinical trials
