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Radiation-induced double-strand breaks by internal ex vivo irradiation of lymphocytes: Validation of a Monte Carlo simulation model using GATE and Geant4-DNA
CONCLUSION: This study describes a model to simulate the DNA DSB damage in lymphocyte nuclei validated by experimental data obtained from internal ex vivo blood irradiation with radionuclides frequently used in diagnostic and therapeutic procedures in nuclear medicine.PMID:37599196 | DOI:10.1016/j.zemedi.2023.07.007 (Source: Zeitschrift fur Medizinische Physik)
Source: Zeitschrift fur Medizinische Physik - August 20, 2023 Category: Radiology Authors: Maikol Salas-Ramirez Lydia Maigne Giovanna Fois Harry Scherthan Michael Lassmann Uta Eberlein Source Type: research

Gamma radiation detector selection for CT scanner
Z Med Phys. 2023 Aug 14:S0939-3889(23)00088-0. doi: 10.1016/j.zemedi.2023.07.006. Online ahead of print.ABSTRACTThree types of gamma radiation detectors associated with distributed electronics namely, NaI (Tl), HPGe and LaBr3(Ce) are compared primarily focusing on electronic noise and scattering noise. Additionally, detectors of same make, material, size and electronics are also compared. A methodology is proposed to select the most suitable detector for computed tomography (CT) among the available options. Standard deviation parameter is employed to estimate electronic noise without performing CT experiment. Kanpur theore...
Source: Zeitschrift fur Medizinische Physik - August 16, 2023 Category: Radiology Authors: Kajal Kumari Mayank Goswami Source Type: research

Radiation combined with ultrasound and microbubbles: A potential novel strategy for cancer treatment
Z Med Phys. 2023 Aug 14:S0939-3889(23)00049-1. doi: 10.1016/j.zemedi.2023.04.007. Online ahead of print.ABSTRACTCancer is one of the leading causes of death worldwide. Several emerging technologies are helping to battle cancer. Cancer therapies have been effective at killing cancer cells, but a large portion of patients still die to this disease every year. As such, more aggressive treatments of primary cancers are employed and have been shown to be capable of saving a greater number of lives. Recent research advances the field of cancer therapy by employing the use of physical methods to alter tumor biology. It uses micro...
Source: Zeitschrift fur Medizinische Physik - August 16, 2023 Category: Radiology Authors: Deepa Sharma Kai Xuan Leong Daniel Palhares Gregory J Czarnota Source Type: research

Comparison of different neurite density metrics with brain asymmetry evaluation
Z Med Phys. 2023 Aug 7:S0939-3889(23)00085-5. doi: 10.1016/j.zemedi.2023.07.003. Online ahead of print.ABSTRACTThe standard diffusion MRI model with intra- and extra-axonal water pools offers a set of microstructural parameters describing brain white matter architecture. However, non-linearities in the standard model and diffusion data contamination by noise and imaging artefacts make estimation of diffusion metrics challenging. In order to develop reliable diffusion approaches and to avoid computational model degeneracy, additional theoretical assumptions allowing stable numerical implementations are required. Advanced di...
Source: Zeitschrift fur Medizinische Physik - August 10, 2023 Category: Radiology Authors: Ivan I Maximov Lars T Westlye Source Type: research