Activation of BMP4-pSmad1/5 pathway impairs the function of VSMCs in intracranial aneurysms
This study aimed to investigate the effects of BMP4 on VSMCs and its underlying mechanisms. BMP4 was upregulated in the VSMCs of IAs and caused apoptosis of VSMCs through Smad1/5 phosphorylation. In addition, BMP4 overexpression significantly promoted the proliferation and migration of VSMCs and induced a phenotypic transformation from contractile to inflammatory. Our findings facilitate further understanding of the occurrence and development of IAs and provide a potential therapeutic target.PMID:37774964 | DOI:10.1016/j.vph.2023.107236 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Luojiang Zhu Haishuang Tang Congyan Wu Yanpeng Wei Qiang Li Dongwei Dai Pengfei Yang Qinghai Huang Yi Xu Jianmin Liu Rui Zhao Qiao Zuo Source Type: research
Activation of BMP4-pSmad1/5 pathway impairs the function of VSMCs in intracranial aneurysms
This study aimed to investigate the effects of BMP4 on VSMCs and its underlying mechanisms. BMP4 was upregulated in the VSMCs of IAs and caused apoptosis of VSMCs through Smad1/5 phosphorylation. In addition, BMP4 overexpression significantly promoted the proliferation and migration of VSMCs and induced a phenotypic transformation from contractile to inflammatory. Our findings facilitate further understanding of the occurrence and development of IAs and provide a potential therapeutic target.PMID:37774964 | DOI:10.1016/j.vph.2023.107236 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Luojiang Zhu Haishuang Tang Congyan Wu Yanpeng Wei Qiang Li Dongwei Dai Pengfei Yang Qinghai Huang Yi Xu Jianmin Liu Rui Zhao Qiao Zuo Source Type: research
Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension
In this study, we aimed to investigate the role of GRK6 in PAH and determine its potential as a therapeutic target. We utilised hypoxia- and SU5416-induced PAH mouse models and a monocrotaline-induced PAH rat model to analyse the involvement of GRK6. We conducted gain- and loss-of-function experiments using mouse PASMCs. Modulation of GRK6 expression was achieved via a lentiviral vector in vitro and an adeno-associated virus serotype 1 encoding GRK6 in vivo. GRK6 was significantly downregulated in the lung tissues of PAH mice and rats, predominantly in PASMCs. Knockout of GRK6 exacerbated PAH, while both therapeutic and pr...
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Chenchen Liu Naifu Wan Lijiang Wei Wuwei Rong Wentong Zhu Meifeng Xie Yanling Zhang Zhihua Liu Qing Jing Ankang Lyu Source Type: research
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension
CONCLUSION: These results suggest GPR75 has a significant role in the development of hypoxia-induced PH.PMID:37742819 | DOI:10.1016/j.vph.2023.107235 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Catherine A D'Addario Shun Matsumura Atsushi Kitagawa Gregg M Lainer Frank Zhang Melinee D'silva Mohammad Y Khan Ghezal Froogh Artiom Gruzdev Darryl C Zeldin Michal L Schwartzman Sachin A Gupte Source Type: research
Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension
In this study, we aimed to investigate the role of GRK6 in PAH and determine its potential as a therapeutic target. We utilised hypoxia- and SU5416-induced PAH mouse models and a monocrotaline-induced PAH rat model to analyse the involvement of GRK6. We conducted gain- and loss-of-function experiments using mouse PASMCs. Modulation of GRK6 expression was achieved via a lentiviral vector in vitro and an adeno-associated virus serotype 1 encoding GRK6 in vivo. GRK6 was significantly downregulated in the lung tissues of PAH mice and rats, predominantly in PASMCs. Knockout of GRK6 exacerbated PAH, while both therapeutic and pr...
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Chenchen Liu Naifu Wan Lijiang Wei Wuwei Rong Wentong Zhu Meifeng Xie Yanling Zhang Zhihua Liu Qing Jing Ankang Lyu Source Type: research
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension
CONCLUSION: These results suggest GPR75 has a significant role in the development of hypoxia-induced PH.PMID:37742819 | DOI:10.1016/j.vph.2023.107235 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Catherine A D'Addario Shun Matsumura Atsushi Kitagawa Gregg M Lainer Frank Zhang Melinee D'silva Mohammad Y Khan Ghezal Froogh Artiom Gruzdev Darryl C Zeldin Michal L Schwartzman Sachin A Gupte Source Type: research
Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension
In this study, we aimed to investigate the role of GRK6 in PAH and determine its potential as a therapeutic target. We utilised hypoxia- and SU5416-induced PAH mouse models and a monocrotaline-induced PAH rat model to analyse the involvement of GRK6. We conducted gain- and loss-of-function experiments using mouse PASMCs. Modulation of GRK6 expression was achieved via a lentiviral vector in vitro and an adeno-associated virus serotype 1 encoding GRK6 in vivo. GRK6 was significantly downregulated in the lung tissues of PAH mice and rats, predominantly in PASMCs. Knockout of GRK6 exacerbated PAH, while both therapeutic and pr...
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Chenchen Liu Naifu Wan Lijiang Wei Wuwei Rong Wentong Zhu Meifeng Xie Yanling Zhang Zhihua Liu Qing Jing Ankang Lyu Source Type: research
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension
CONCLUSION: These results suggest GPR75 has a significant role in the development of hypoxia-induced PH.PMID:37742819 | DOI:10.1016/j.vph.2023.107235 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Catherine A D'Addario Shun Matsumura Atsushi Kitagawa Gregg M Lainer Frank Zhang Melinee D'silva Mohammad Y Khan Ghezal Froogh Artiom Gruzdev Darryl C Zeldin Michal L Schwartzman Sachin A Gupte Source Type: research
Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension
In this study, we aimed to investigate the role of GRK6 in PAH and determine its potential as a therapeutic target. We utilised hypoxia- and SU5416-induced PAH mouse models and a monocrotaline-induced PAH rat model to analyse the involvement of GRK6. We conducted gain- and loss-of-function experiments using mouse PASMCs. Modulation of GRK6 expression was achieved via a lentiviral vector in vitro and an adeno-associated virus serotype 1 encoding GRK6 in vivo. GRK6 was significantly downregulated in the lung tissues of PAH mice and rats, predominantly in PASMCs. Knockout of GRK6 exacerbated PAH, while both therapeutic and pr...
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Chenchen Liu Naifu Wan Lijiang Wei Wuwei Rong Wentong Zhu Meifeng Xie Yanling Zhang Zhihua Liu Qing Jing Ankang Lyu Source Type: research
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension
CONCLUSION: These results suggest GPR75 has a significant role in the development of hypoxia-induced PH.PMID:37742819 | DOI:10.1016/j.vph.2023.107235 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Catherine A D'Addario Shun Matsumura Atsushi Kitagawa Gregg M Lainer Frank Zhang Melinee D'silva Mohammad Y Khan Ghezal Froogh Artiom Gruzdev Darryl C Zeldin Michal L Schwartzman Sachin A Gupte Source Type: research
Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension
In this study, we aimed to investigate the role of GRK6 in PAH and determine its potential as a therapeutic target. We utilised hypoxia- and SU5416-induced PAH mouse models and a monocrotaline-induced PAH rat model to analyse the involvement of GRK6. We conducted gain- and loss-of-function experiments using mouse PASMCs. Modulation of GRK6 expression was achieved via a lentiviral vector in vitro and an adeno-associated virus serotype 1 encoding GRK6 in vivo. GRK6 was significantly downregulated in the lung tissues of PAH mice and rats, predominantly in PASMCs. Knockout of GRK6 exacerbated PAH, while both therapeutic and pr...
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Chenchen Liu Naifu Wan Lijiang Wei Wuwei Rong Wentong Zhu Meifeng Xie Yanling Zhang Zhihua Liu Qing Jing Ankang Lyu Source Type: research
Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension
CONCLUSION: These results suggest GPR75 has a significant role in the development of hypoxia-induced PH.PMID:37742819 | DOI:10.1016/j.vph.2023.107235 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Catherine A D'Addario Shun Matsumura Atsushi Kitagawa Gregg M Lainer Frank Zhang Melinee D'silva Mohammad Y Khan Ghezal Froogh Artiom Gruzdev Darryl C Zeldin Michal L Schwartzman Sachin A Gupte Source Type: research
Roles of endothelial and smooth muscle cell dysfunction and vasa vasorum in vasomotor disorders in ischemia with no obstructive coronary artery disease
Vascul Pharmacol. 2023 Sep 21:107234. doi: 10.1016/j.vph.2023.107234. Online ahead of print.ABSTRACTRecently, the importance has emerged of ischemia with no obstructive coronary artery disease (INOCA), for which endothelial and vascular smooth muscle cell (VSMC) dysfunctions and alterations in coronary vasa vasorum are involved. Regarding endothelial vasodilator functions, both endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor play important roles in modulating vascular tone, especially in the microcirculation. Recent studies have suggested systemic endothelial dysfunction in INOCA. Regarding ...
Source: Vascular Pharmacology - September 23, 2023 Category: Drugs & Pharmacology Authors: Hiroaki Shimokawa Source Type: research
Roles of endothelial and smooth muscle cell dysfunction and vasa vasorum in vasomotor disorders in ischemia with no obstructive coronary artery disease
Vascul Pharmacol. 2023 Sep 21:107234. doi: 10.1016/j.vph.2023.107234. Online ahead of print.ABSTRACTRecently, the importance has emerged of ischemia with no obstructive coronary artery disease (INOCA), for which endothelial and vascular smooth muscle cell (VSMC) dysfunctions and alterations in coronary vasa vasorum are involved. Regarding endothelial vasodilator functions, both endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor play important roles in modulating vascular tone, especially in the microcirculation. Recent studies have suggested systemic endothelial dysfunction in INOCA. Regarding ...
Source: Vascular Pharmacology - September 23, 2023 Category: Drugs & Pharmacology Authors: Hiroaki Shimokawa Source Type: research
Hypertension, coronary artery disease and myocardial ischemic syndromes
Vascul Pharmacol. 2023 Sep 20:107230. doi: 10.1016/j.vph.2023.107230. Online ahead of print.ABSTRACTHypertension represents a major contributor to the development of coronary artery disease. The pathophysiological mechanisms underlying the link between hypertension and CAD are complex and include overactivation of neurohormones, accelerated development of the atherosclerotic plaque, endothelial dysfunction, altered intramyocardial coronary circulation, hypertension-mediated cardiac and vascular damage and the relationship between arterial stiffness and coronary perfusion. BP reduction is associated with a significant decre...
Source: Vascular Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Authors: Massimo Volpe Giovanna Gallo Source Type: research
