Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17;154:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin ha...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17;154:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin ha...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17;154:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin ha...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17;154:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin ha...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17;154:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin ha...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin has be...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Adipsin in the pathogenesis of cardiovascular diseases
Vascul Pharmacol. 2023 Dec 17:107270. doi: 10.1016/j.vph.2023.107270. Online ahead of print.ABSTRACTAdipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition. However, complement overactivation has been implicated in the etiology of numerous disorders, including cardiovascular disease (CVD). Increased circulating level of adipsin has be...
Source: Vascular Pharmacology - December 19, 2023 Category: Drugs & Pharmacology Authors: Ayobami Dare Shi-You Chen Source Type: research
Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm
In this study, we analyzed publicly available single-cell or bulk RNA sequencing data comparing healthy and aneurysmal mouse aortic tissues. In both healthy and diseased aortas, Carmn expression was enriched in SMCs characterized by the high expression of SMC-specific contractile proteins including Myh11 and Acta2. Carmn expression levels varied among the sub-clusters of SMCs and consequently along the aortic tree. Comparing to the corresponding sham aorta, aortas from 3 distinct AAA models contained less Carmn. To validate the Carmn downregulation, we induced AAA using the Angiotensin II and CaCl2 models. In situ hybridiz...
Source: Vascular Pharmacology - December 14, 2023 Category: Drugs & Pharmacology Authors: Huan Yang Ting Zhou Bo Liu Source Type: research
Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm
In this study, we analyzed publicly available single-cell or bulk RNA sequencing data comparing healthy and aneurysmal mouse aortic tissues. In both healthy and diseased aortas, Carmn expression was enriched in SMCs characterized by the high expression of SMC-specific contractile proteins including Myh11 and Acta2. Carmn expression levels varied among the sub-clusters of SMCs and consequently along the aortic tree. Comparing to the corresponding sham aorta, aortas from 3 distinct AAA models contained less Carmn. To validate the Carmn downregulation, we induced AAA using the Angiotensin II and CaCl2 models. In situ hybridiz...
Source: Vascular Pharmacology - December 14, 2023 Category: Drugs & Pharmacology Authors: Huan Yang Ting Zhou Bo Liu Source Type: research
Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm
In this study, we analyzed publicly available single-cell or bulk RNA sequencing data comparing healthy and aneurysmal mouse aortic tissues. In both healthy and diseased aortas, Carmn expression was enriched in SMCs characterized by the high expression of SMC-specific contractile proteins including Myh11 and Acta2. Carmn expression levels varied among the sub-clusters of SMCs and consequently along the aortic tree. Comparing to the corresponding sham aorta, aortas from 3 distinct AAA models contained less Carmn. To validate the Carmn downregulation, we induced AAA using the Angiotensin II and CaCl2 models. In situ hybridiz...
Source: Vascular Pharmacology - December 14, 2023 Category: Drugs & Pharmacology Authors: Huan Yang Ting Zhou Bo Liu Source Type: research
Macrophage-mediated downregulation of lncRNA Carmn in mouse abdominal aortic aneurysm
In this study, we analyzed publicly available single-cell or bulk RNA sequencing data comparing healthy and aneurysmal mouse aortic tissues. In both healthy and diseased aortas, Carmn expression was enriched in SMCs characterized by the high expression of SMC-specific contractile proteins including Myh11 and Acta2. Carmn expression levels varied among the sub-clusters of SMCs and consequently along the aortic tree. Comparing to the corresponding sham aorta, aortas from 3 distinct AAA models contained less Carmn. To validate the Carmn downregulation, we induced AAA using the Angiotensin II and CaCl2 models. In situ hybridiz...
Source: Vascular Pharmacology - December 14, 2023 Category: Drugs & Pharmacology Authors: Huan Yang Ting Zhou Bo Liu Source Type: research
Perivascular and epicardial adipose tissue
Vascul Pharmacol. 2023 Dec 8:107254. doi: 10.1016/j.vph.2023.107254. Online ahead of print.NO ABSTRACTPMID:38072220 | DOI:10.1016/j.vph.2023.107254 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 10, 2023 Category: Drugs & Pharmacology Authors: Lina Badimon Gemma Arderiu Gemma Vilahur Teresa Padro Alberto Cordero Guiomar Mendieta Source Type: research
Perivascular and epicardial adipose tissue
Vascul Pharmacol. 2023 Dec 8:107254. doi: 10.1016/j.vph.2023.107254. Online ahead of print.NO ABSTRACTPMID:38072220 | DOI:10.1016/j.vph.2023.107254 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 10, 2023 Category: Drugs & Pharmacology Authors: Lina Badimon Gemma Arderiu Gemma Vilahur Teresa Padro Alberto Cordero Guiomar Mendieta Source Type: research
Perivascular and epicardial adipose tissue
Vascul Pharmacol. 2023 Dec 8:107254. doi: 10.1016/j.vph.2023.107254. Online ahead of print.NO ABSTRACTPMID:38072220 | DOI:10.1016/j.vph.2023.107254 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 10, 2023 Category: Drugs & Pharmacology Authors: Lina Badimon Gemma Arderiu Gemma Vilahur Teresa Padro Alberto Cordero Guiomar Mendieta Source Type: research
Perivascular and epicardial adipose tissue
Vascul Pharmacol. 2023 Dec 8:107254. doi: 10.1016/j.vph.2023.107254. Online ahead of print.NO ABSTRACTPMID:38072220 | DOI:10.1016/j.vph.2023.107254 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 10, 2023 Category: Drugs & Pharmacology Authors: Lina Badimon Gemma Arderiu Gemma Vilahur Teresa Padro Alberto Cordero Guiomar Mendieta Source Type: research
