Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention
Vascul Pharmacol. 2023 Oct 21:107238. doi: 10.1016/j.vph.2023.107238. Online ahead of print.ABSTRACTInflammation and hyperlipidemia act synergistically to drive atherosclerotic progression. Multiple randomized trials now demonstrate that "lower is better" not only for LDLC, but also for hsCRP. Recent data among statin treated patients indicates that residual inflammatory risk is a stronger determinant of recurrent events than residual cholesterol risk. Based on trial data demonstrating a 31% reduction in events with minimal side effects, low-dose colchicine (0.5 mg daily) has been approved by the United States Food and Dru...
Source: Vascular Pharmacology - October 23, 2023 Category: Drugs & Pharmacology Authors: Paul M Ridker Source Type: research
Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention
Vascul Pharmacol. 2023 Oct 21:107238. doi: 10.1016/j.vph.2023.107238. Online ahead of print.ABSTRACTInflammation and hyperlipidemia act synergistically to drive atherosclerotic progression. Multiple randomized trials now demonstrate that "lower is better" not only for LDLC, but also for hsCRP. Recent data among statin treated patients indicates that residual inflammatory risk is a stronger determinant of recurrent events than residual cholesterol risk. Based on trial data demonstrating a 31% reduction in events with minimal side effects, low-dose colchicine (0.5 mg daily) has been approved by the United States Food and Dru...
Source: Vascular Pharmacology - October 23, 2023 Category: Drugs & Pharmacology Authors: Paul M Ridker Source Type: research
Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention
Vascul Pharmacol. 2023 Oct 21:107238. doi: 10.1016/j.vph.2023.107238. Online ahead of print.ABSTRACTInflammation and hyperlipidemia act synergistically to drive atherosclerotic progression. Multiple randomized trials now demonstrate that "lower is better" not only for LDLC, but also for hsCRP. Recent data among statin treated patients indicates that residual inflammatory risk is a stronger determinant of recurrent events than residual cholesterol risk. Based on trial data demonstrating a 31% reduction in events with minimal side effects, low-dose colchicine (0.5 mg daily) has been approved by the United States Food and Dru...
Source: Vascular Pharmacology - October 23, 2023 Category: Drugs & Pharmacology Authors: Paul M Ridker Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
Animal experimental models of ischemic limbs - A systematic review
CONCLUSIONS: This review shows that mice are among the most commonly used animals in limb ischemia research. Simple ligation and excision of the femoral artery is the most common method of creating an ischemic limb; nevertheless, it can result in acute rather than chronic ischemia. A two-stage sequential approach and methods using ameroid constrictors or endovascular blinded stent grafts are more suitable for creating a gradual arterial occlusion typically seen in humans. Selecting the right mouse strain or animal with artificially produced diabetes or hyperlipidaemia is crucial in chronic ischemic limb research. Moreover,...
Source: Vascular Pharmacology - October 6, 2023 Category: Drugs & Pharmacology Authors: Veronika Lovasova Robert Bem Jaroslav Chlupac Michal Dubsky Jitka Husakova Andrea Nemcova Jiri Fronek Source Type: research
