Activation of BMP4-pSmad1/5 pathway impairs the function of VSMCs in intracranial aneurysms

This study aimed to investigate the effects of BMP4 on VSMCs and its underlying mechanisms. BMP4 was upregulated in the VSMCs of IAs and caused apoptosis of VSMCs through Smad1/5 phosphorylation. In addition, BMP4 overexpression significantly promoted the proliferation and migration of VSMCs and induced a phenotypic transformation from contractile to inflammatory. Our findings facilitate further understanding of the occurrence and development of IAs and provide a potential therapeutic target.PMID:37774964 | DOI:10.1016/j.vph.2023.107236

Source: Vascular Pharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Luojiang Zhu Haishuang Tang Congyan Wu Yanpeng Wei Qiang Li Dongwei Dai Pengfei Yang Qinghai Huang Yi Xu Jianmin Liu Rui Zhao Qiao Zuo Source Type: research