Contributors
VIRGINIA R. LITLE, MD (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - October 2, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Contents
Virginia R. Litle (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - October 2, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Forthcoming Issues
Thoracic Outlet Syndrome (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - October 2, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Mesothelioma Biomarkers
Malignant pleural mesothelioma (MPM) is an asbestos-related neoplasm that can only be treated successfully when correctly diagnosed and treated early. The asbestos-exposed population is a high-risk group that could benefit from sensitive and specific blood- or tissue-based biomarkers. We review recent work with biomarker development in MPM and literature of the last 20 years on the most promising blood- and tissue-based biomarkers. Proteomic, genomic, and epigenomic platforms are covered. SMRP is the only validated blood-based biomarker with diagnostic, monitoring and prognostic value. To strengthen development and testi...
Source: Thoracic Surgery Clinics - September 13, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Harvey I. Pass, Marjan Alimi, Michele Carbone, Haining Yang, Chandra M. Goparaju Source Type: research
The Staging of Malignant Pleural Mesothelioma
Staging of malignant pleural mesothelioma has been challenging because of a paucity of cases and poor survival. At least 5 staging systems were proposed before 1990 until the first consensus system was published in 1995. This system used tumor, node, metastasis designations and borrowed heavily from parenchymal lung cancer descriptors. With the establishment of a database to collect cases from 1995 to 2013, evidence-based revisions to the 1995 staging classification were published in 2016. With improving imaging technology, clinical staging will become more refined and, it is hoped, more useful for prognostication even wit...
Source: Thoracic Surgery Clinics - September 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Caleb J. Euhus, Robert Taylor Ripley Source Type: research
Extended Pleurectomy and Decortication for Malignant Pleural Mesothelioma
Extended pleurectomy and decortication (ePD) is a difficult operation performed for the surgical resection of malignant pleural mesothelioma that can achieve a macroscopic complete resection with preservation of the lung. With lower perioperative mortality, similar long-term survival, and better tolerance in patients with lower performance status, ePD has become the preferred operation rather than extrapleural pneumonectomy despite lack of a direct comparison. As ePD has become more popular, international collaboration is underway to create surgical guidelines based on collection of operative data. These efforts will impro...
Source: Thoracic Surgery Clinics - September 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: R. Taylor Ripley Source Type: research
The Role of Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma
Extrapleural pneumonectomy (EPP) is the most extensive form of surgery for mesothelioma, involving en bloc resection of visceral and parietal pleura, lung, diaphragm and pericardium, with reconstruction of the pericardium and diaphragm. It can be performed safely in carefully selected patients. It should be performed in experienced centers as part of a multimodality treatment plan. The SMART approach, with a short course of induction hemithoracic radiation followed by EPP has demonstrated safety and value of hypofractionated hemithoracic radiation combined with complete macroscopic resection. We are conducting a clinical t...
Source: Thoracic Surgery Clinics - September 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Laura L. Donahoe, Marc de Perrot Source Type: research
The Molecular Basis of Malignant Pleural Mesothelioma
This article reviews these features and discusses the implications of advances in MPM molecular biology in clinical practice. (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - September 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Benjamin Wadowski, Assunta De Rienzo, Raphael Bueno Source Type: research
Radiation Therapy for Malignant Pleural Mesothelioma
The treatment of malignant pleural mesothelioma with radiation therapy has always been a technical challenge. For many years, radiation therapy was delivered after extrapleural pneumonectomy with acceptable results. As the utilization of pleurectomy/decortication increased, techniques, such as pleural intensity-modulated radiation therapy (IMRT) have been introduced. The experience with these techniques have grown and multiple trials using IMRT, both in the setting of extrapleural pneumonectomy or pleurectomy, are being conducted to assess its effectiveness. (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - September 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kenneth E. Rosenzweig Source Type: research
Malignant Pleural Mesothelioma: An Insidious Disease
We are excited to bring you this focused issue for the Thoracic Surgery Clinics on “Malignant Pleural Mesothelioma,” an insidious disease with a projected rise in incidence secondary to environmental factors, including the World Trade Center tragedy, which transpired almost 20 years ago. Our previous issue on this topic was appropriately guest edited by the legendary Dr David Sugarbaker in the inaugural year when Chest Surgery Clinics was renamed Thoracic Surgery Clinics in 2004. After many advances in the field, including molecular characterization of the tumor, identification of potential biomarkers, and controversie...
Source: Thoracic Surgery Clinics - September 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Virginia R. Litle Tags: Foreword Source Type: research
Interventional Pulmonology
Interventional pulmonology is a dynamic and evolving field in respiratory medicine. Advances have improved the ability to diagnose and manage diseases of the airways. A shift toward early detection of malignant disease has generated a focus on innovative diagnostic techniques. With patient populations living longer with malignant and benign diseases, the role for interventional bronchoscopy has grown. In cancer groups, novel immunotherapies have improved the prospects of clinical outcomes and reignited a focus on optimizing patient performance status to enable access to anticancer therapy. This review discusses current and...
Source: Thoracic Surgery Clinics - June 25, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Hardeep S. Kalsi, Ricky Thakrar, Andre F. Gosling, Shahzad Shaefi, Neal Navani Source Type: research
Open, Minimally Invasive, and Robotic Approaches for Esophagectomy
Esophageal cancer requires a multimodality treatment approach, with surgical resection a key component in many cases. When it comes to esophagectomy, several approaches and techniques exist, including transhiatal versus transthoracic and open versus minimally invasive. Each approach has its associated risks and advantages. When determining the optimal approach and technique, several variables need to be considered. The key variables include patient and tumor characteristics, as well as surgeon comfort and experience with each approach. Regardless of the approach, the goal should remain the same, that is, performing a safe ...
Source: Thoracic Surgery Clinics - June 25, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Tadeusz D. Witek, Thomas J. Melvin, James D. Luketich, Inderpal S. Sarkaria Source Type: research
Perioperative Management of the Thoracic Surgery Patient
THORACIC SURGERY CLINICS (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - June 25, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Virginia R. Litle, Robert J. Canelli Source Type: research
Copyright
ELSEVIER (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - June 25, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
Contributors
VIRGINIA R. LITLE, MD (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - June 25, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research
