Optimal dispersal and diffusion-enhanced robustness in two-patch metapopulations: origin's saddle-source nature matters
Theory Biosci. 2024 Feb 21. doi: 10.1007/s12064-023-00411-2. Online ahead of print.ABSTRACTA two-patch logistic metapopulation model is investigated both analytically and numerically focusing on the impact of dispersal on population dynamics. First, the dependence of the global dynamics on the stability type of the full extinction equilibrium point is tackled. Then, the behaviour of the total population with respect to the dispersal is studied analytically. Our findings demonstrate that diffusion plays a crucial role in the preservation of both subpopulations and the full metapopulation under the presence of stochastic per...
Source: Theory in Biosciences - February 21, 2024 Category: Biology Authors: Marc Jorba-Cusc ó Ruth I Oliva-Z úniga Josep Sardany és Daniel P érez-Palau Source Type: research
Optimal dispersal and diffusion-enhanced robustness in two-patch metapopulations: origin's saddle-source nature matters
Theory Biosci. 2024 Feb 21. doi: 10.1007/s12064-023-00411-2. Online ahead of print.ABSTRACTA two-patch logistic metapopulation model is investigated both analytically and numerically focusing on the impact of dispersal on population dynamics. First, the dependence of the global dynamics on the stability type of the full extinction equilibrium point is tackled. Then, the behaviour of the total population with respect to the dispersal is studied analytically. Our findings demonstrate that diffusion plays a crucial role in the preservation of both subpopulations and the full metapopulation under the presence of stochastic per...
Source: Theory in Biosciences - February 21, 2024 Category: Biology Authors: Marc Jorba-Cusc ó Ruth I Oliva-Z úniga Josep Sardany és Daniel P érez-Palau Source Type: research
Optimal dispersal and diffusion-enhanced robustness in two-patch metapopulations: origin's saddle-source nature matters
Theory Biosci. 2024 Feb 21. doi: 10.1007/s12064-023-00411-2. Online ahead of print.ABSTRACTA two-patch logistic metapopulation model is investigated both analytically and numerically focusing on the impact of dispersal on population dynamics. First, the dependence of the global dynamics on the stability type of the full extinction equilibrium point is tackled. Then, the behaviour of the total population with respect to the dispersal is studied analytically. Our findings demonstrate that diffusion plays a crucial role in the preservation of both subpopulations and the full metapopulation under the presence of stochastic per...
Source: Theory in Biosciences - February 21, 2024 Category: Biology Authors: Marc Jorba-Cusc ó Ruth I Oliva-Z úniga Josep Sardany és Daniel P érez-Palau Source Type: research
Optimal dispersal and diffusion-enhanced robustness in two-patch metapopulations: origin's saddle-source nature matters
Theory Biosci. 2024 Feb 21. doi: 10.1007/s12064-023-00411-2. Online ahead of print.ABSTRACTA two-patch logistic metapopulation model is investigated both analytically and numerically focusing on the impact of dispersal on population dynamics. First, the dependence of the global dynamics on the stability type of the full extinction equilibrium point is tackled. Then, the behaviour of the total population with respect to the dispersal is studied analytically. Our findings demonstrate that diffusion plays a crucial role in the preservation of both subpopulations and the full metapopulation under the presence of stochastic per...
Source: Theory in Biosciences - February 21, 2024 Category: Biology Authors: Marc Jorba-Cusc ó Ruth I Oliva-Z úniga Josep Sardany és Daniel P érez-Palau Source Type: research
Optimal dispersal and diffusion-enhanced robustness in two-patch metapopulations: origin's saddle-source nature matters
Theory Biosci. 2024 Feb 21. doi: 10.1007/s12064-023-00411-2. Online ahead of print.ABSTRACTA two-patch logistic metapopulation model is investigated both analytically and numerically focusing on the impact of dispersal on population dynamics. First, the dependence of the global dynamics on the stability type of the full extinction equilibrium point is tackled. Then, the behaviour of the total population with respect to the dispersal is studied analytically. Our findings demonstrate that diffusion plays a crucial role in the preservation of both subpopulations and the full metapopulation under the presence of stochastic per...
Source: Theory in Biosciences - February 21, 2024 Category: Biology Authors: Marc Jorba-Cusc ó Ruth I Oliva-Z úniga Josep Sardany és Daniel P érez-Palau Source Type: research
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Theory Biosci. 2024 Jan 30. doi: 10.1007/s12064-023-00410-3. Online ahead of print.ABSTRACTMathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and mesenchymal) have been developed. However, seldom do models incorporate both plasticity and mutationally driven resistance, particular...
Source: Theory in Biosciences - January 30, 2024 Category: Biology Authors: Anuraag Bukkuri Source Type: research
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Theory Biosci. 2024 Jan 30. doi: 10.1007/s12064-023-00410-3. Online ahead of print.ABSTRACTMathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and mesenchymal) have been developed. However, seldom do models incorporate both plasticity and mutationally driven resistance, particular...
Source: Theory in Biosciences - January 30, 2024 Category: Biology Authors: Anuraag Bukkuri Source Type: research
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Theory Biosci. 2024 Jan 30. doi: 10.1007/s12064-023-00410-3. Online ahead of print.ABSTRACTMathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and mesenchymal) have been developed. However, seldom do models incorporate both plasticity and mutationally driven resistance, particular...
Source: Theory in Biosciences - January 30, 2024 Category: Biology Authors: Anuraag Bukkuri Source Type: research
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Theory Biosci. 2024 Jan 30. doi: 10.1007/s12064-023-00410-3. Online ahead of print.ABSTRACTMathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and mesenchymal) have been developed. However, seldom do models incorporate both plasticity and mutationally driven resistance, particular...
Source: Theory in Biosciences - January 30, 2024 Category: Biology Authors: Anuraag Bukkuri Source Type: research
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Theory Biosci. 2024 Jan 30. doi: 10.1007/s12064-023-00410-3. Online ahead of print.ABSTRACTMathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and mesenchymal) have been developed. However, seldom do models incorporate both plasticity and mutationally driven resistance, particular...
Source: Theory in Biosciences - January 30, 2024 Category: Biology Authors: Anuraag Bukkuri Source Type: research
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Theory Biosci. 2024 Jan 30. doi: 10.1007/s12064-023-00410-3. Online ahead of print.ABSTRACTMathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial and mesenchymal) have been developed. However, seldom do models incorporate both plasticity and mutationally driven resistance, particular...
Source: Theory in Biosciences - January 30, 2024 Category: Biology Authors: Anuraag Bukkuri Source Type: research
Speciation, natural selection, and networks: three historians versus theoretical population geneticists
Theory Biosci. 2024 Jan 29. doi: 10.1007/s12064-024-00412-9. Online ahead of print.ABSTRACTIn 1913, the geneticist William Bateson called for a halt in studies of genetic phenomena until evolutionary fundamentals had been sufficiently addressed at the molecular level. Nevertheless, in the 1960s, the theoretical population geneticists celebrated a "modern synthesis" of the teachings of Mendel and Darwin, with an exclusive role for natural selection in speciation. This was supported, albeit with minor reservations, by historians Mark Adams and William Provine, who taught it to generations of students. In subsequent decades, ...
Source: Theory in Biosciences - January 28, 2024 Category: Biology Authors: Donald R Forsdyke Source Type: research
Thomas S. Kuhn: key to a better understanding of the extended evolutionary synthesis
Theory Biosci. 2023 Nov 17. doi: 10.1007/s12064-023-00409-w. Online ahead of print.ABSTRACTIn recent years, some scholars have explicitly questioned the desirability or utility of applying the classical and "old-fashioned" theories of scientific change by the likes of Karl Popper and Thomas S. Kuhn to the question of the precise nature and significance of the extended evolutionary synthesis (EES). Supposedly, these twentieth-century philosophers are completely irrelevant for a better understanding of this new theoretical framework for the study of evolution. Here, it will be argued that the EES can be fruitfully interprete...
Source: Theory in Biosciences - November 17, 2023 Category: Biology Authors: Koen B Tanghe Source Type: research
Thomas S. Kuhn: key to a better understanding of the extended evolutionary synthesis
Theory Biosci. 2023 Nov 17. doi: 10.1007/s12064-023-00409-w. Online ahead of print.ABSTRACTIn recent years, some scholars have explicitly questioned the desirability or utility of applying the classical and "old-fashioned" theories of scientific change by the likes of Karl Popper and Thomas S. Kuhn to the question of the precise nature and significance of the extended evolutionary synthesis (EES). Supposedly, these twentieth-century philosophers are completely irrelevant for a better understanding of this new theoretical framework for the study of evolution. Here, it will be argued that the EES can be fruitfully interprete...
Source: Theory in Biosciences - November 17, 2023 Category: Biology Authors: Koen B Tanghe Source Type: research
Thomas S. Kuhn: key to a better understanding of the extended evolutionary synthesis
Theory Biosci. 2023 Nov 17. doi: 10.1007/s12064-023-00409-w. Online ahead of print.ABSTRACTIn recent years, some scholars have explicitly questioned the desirability or utility of applying the classical and "old-fashioned" theories of scientific change by the likes of Karl Popper and Thomas S. Kuhn to the question of the precise nature and significance of the extended evolutionary synthesis (EES). Supposedly, these twentieth-century philosophers are completely irrelevant for a better understanding of this new theoretical framework for the study of evolution. Here, it will be argued that the EES can be fruitfully interprete...
Source: Theory in Biosciences - November 17, 2023 Category: Biology Authors: Koen B Tanghe Source Type: research
