Evolutionary honing in and mutational replacement: how long-term directed mutational responses to specific environmental pressures are possible
Theory Biosci. 2023 Mar 11. doi: 10.1007/s12064-023-00387-z. Online ahead of print.ABSTRACTRecent results have shown that the human malaria-resistant hemoglobin S mutation originates de novo more frequently in the gene and in the population where it is of adaptive significance, namely, in the hemoglobin subunit beta gene compared to the nonresistant but otherwise identical 20A[Formula: see text]T mutation in the hemoglobin subunit delta gene, and in sub-Saharan Africans, who have been subject to intense malarial pressure for many generations, compared to northern Europeans, who have not. This finding raises a fundamental c...
Source: Theory in Biosciences - March 10, 2023 Category: Biology Authors: Adi Livnat Daniel Melamed Source Type: research
Path integral control of a stochastic multi-risk SIR pandemic model
Theory Biosci. 2023 Mar 11:1-36. doi: 10.1007/s12064-023-00388-y. Online ahead of print.ABSTRACTIn this paper a Feynman-type path integral control approach is used for a recursive formulation of a health objective function subject to a fatigue dynamics, a forward-looking stochastic multi-risk susceptible-infective-recovered (SIR) model with risk-group's Bayesian opinion dynamics toward vaccination against COVID-19. My main interest lies in solving a minimization of a policy-maker's social cost which depends on some deterministic weight. I obtain an optimal lock-down intensity from a Wick-rotated Schrödinger-type equation ...
Source: Theory in Biosciences - March 10, 2023 Category: Biology Authors: Paramahansa Pramanik Source Type: research
Evolutionary honing in and mutational replacement: how long-term directed mutational responses to specific environmental pressures are possible
Theory Biosci. 2023 Mar 11. doi: 10.1007/s12064-023-00387-z. Online ahead of print.ABSTRACTRecent results have shown that the human malaria-resistant hemoglobin S mutation originates de novo more frequently in the gene and in the population where it is of adaptive significance, namely, in the hemoglobin subunit beta gene compared to the nonresistant but otherwise identical 20A[Formula: see text]T mutation in the hemoglobin subunit delta gene, and in sub-Saharan Africans, who have been subject to intense malarial pressure for many generations, compared to northern Europeans, who have not. This finding raises a fundamental c...
Source: Theory in Biosciences - March 10, 2023 Category: Biology Authors: Adi Livnat Daniel Melamed Source Type: research
Path integral control of a stochastic multi-risk SIR pandemic model
Theory Biosci. 2023 Mar 11:1-36. doi: 10.1007/s12064-023-00388-y. Online ahead of print.ABSTRACTIn this paper a Feynman-type path integral control approach is used for a recursive formulation of a health objective function subject to a fatigue dynamics, a forward-looking stochastic multi-risk susceptible-infective-recovered (SIR) model with risk-group's Bayesian opinion dynamics toward vaccination against COVID-19. My main interest lies in solving a minimization of a policy-maker's social cost which depends on some deterministic weight. I obtain an optimal lock-down intensity from a Wick-rotated Schrödinger-type equation ...
Source: Theory in Biosciences - March 10, 2023 Category: Biology Authors: Paramahansa Pramanik Source Type: research
Evolutionary honing in and mutational replacement: how long-term directed mutational responses to specific environmental pressures are possible
Theory Biosci. 2023 Mar 11. doi: 10.1007/s12064-023-00387-z. Online ahead of print.ABSTRACTRecent results have shown that the human malaria-resistant hemoglobin S mutation originates de novo more frequently in the gene and in the population where it is of adaptive significance, namely, in the hemoglobin subunit beta gene compared to the nonresistant but otherwise identical 20A[Formula: see text]T mutation in the hemoglobin subunit delta gene, and in sub-Saharan Africans, who have been subject to intense malarial pressure for many generations, compared to northern Europeans, who have not. This finding raises a fundamental c...
Source: Theory in Biosciences - March 10, 2023 Category: Biology Authors: Adi Livnat Daniel Melamed Source Type: research
