A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease
In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is p...
Source: Theory in Biosciences - April 18, 2023 Category: Biology Authors: Ali Yazdani Fariba Bahrami Arash Pourgholaminejad Reza Moghadasali Source Type: research
A computational investigation of cis-gene regulation in evolution
Theory Biosci. 2023 Apr 11. doi: 10.1007/s12064-023-00391-3. Online ahead of print.ABSTRACTIn biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via th...
Source: Theory in Biosciences - April 11, 2023 Category: Biology Authors: Mohammed Mahmud Mulugeta Bekele Narayan Behera Source Type: research
A computational investigation of cis-gene regulation in evolution
Theory Biosci. 2023 Apr 11. doi: 10.1007/s12064-023-00391-3. Online ahead of print.ABSTRACTIn biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via th...
Source: Theory in Biosciences - April 11, 2023 Category: Biology Authors: Mohammed Mahmud Mulugeta Bekele Narayan Behera Source Type: research
A computational investigation of cis-gene regulation in evolution
Theory Biosci. 2023 Apr 11. doi: 10.1007/s12064-023-00391-3. Online ahead of print.ABSTRACTIn biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via th...
Source: Theory in Biosciences - April 11, 2023 Category: Biology Authors: Mohammed Mahmud Mulugeta Bekele Narayan Behera Source Type: research
A computational investigation of cis-gene regulation in evolution
Theory Biosci. 2023 Apr 11. doi: 10.1007/s12064-023-00391-3. Online ahead of print.ABSTRACTIn biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via th...
Source: Theory in Biosciences - April 11, 2023 Category: Biology Authors: Mohammed Mahmud Mulugeta Bekele Narayan Behera Source Type: research
A computational investigation of cis-gene regulation in evolution
Theory Biosci. 2023 Apr 11. doi: 10.1007/s12064-023-00391-3. Online ahead of print.ABSTRACTIn biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via th...
Source: Theory in Biosciences - April 11, 2023 Category: Biology Authors: Mohammed Mahmud Mulugeta Bekele Narayan Behera Source Type: research
A computational investigation of cis-gene regulation in evolution
Theory Biosci. 2023 Apr 11. doi: 10.1007/s12064-023-00391-3. Online ahead of print.ABSTRACTIn biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via th...
Source: Theory in Biosciences - April 11, 2023 Category: Biology Authors: Mohammed Mahmud Mulugeta Bekele Narayan Behera Source Type: research
