The Cornea: An Ideal Tissue for Regenerative Medicine
Keio J Med. 2024 Feb 17. doi: 10.2302/kjm.2023-0001-IR. Online ahead of print.ABSTRACTRegenerative medicine is a highly anticipated field with hopes to provide cures for previously uncurable diseases such as spinal cord injuries and retinal blindness. Most regenerative medical products use either autologous or allogeneic stem cells, which may or may not be genetically modified. The introduction of induced-pluripotent stem cells (iPSCs) has fueled research in the field, and several iPSC-derived cells/tissues are currently undergoing clinical trials. The cornea is one of the pioneering areas of regenerative medicine, and alr...
Source: The Keio Journal of Medicine - February 18, 2024 Category: Universities & Medical Training Authors: Shigeto Shimmura Emi Inagaki Masatoshi Hirayama Shin Hatou Source Type: research
The Cornea: An Ideal Tissue for Regenerative Medicine
Keio J Med. 2024 Feb 17. doi: 10.2302/kjm.2023-0001-IR. Online ahead of print.ABSTRACTRegenerative medicine is a highly anticipated field with hopes to provide cures for previously uncurable diseases such as spinal cord injuries and retinal blindness. Most regenerative medical products use either autologous or allogeneic stem cells, which may or may not be genetically modified. The introduction of induced-pluripotent stem cells (iPSCs) has fueled research in the field, and several iPSC-derived cells/tissues are currently undergoing clinical trials. The cornea is one of the pioneering areas of regenerative medicine, and alr...
Source: The Keio Journal of Medicine - February 18, 2024 Category: Universities & Medical Training Authors: Shigeto Shimmura Emi Inagaki Masatoshi Hirayama Shin Hatou Source Type: research
Pulmonary symptoms in adolescent and adult patients with a spinal deformity
Keio J Med. 2023;72(4):106. doi: 10.2302/kjm.ABSTRACT_72_4-2.ABSTRACTPatients with spinal deformities, both adolescents and adults, often experience pulmonary symptoms such as shortness of breath during physical exertion and reduced exercise tolerance. These symptoms significantly affect their daily functioning, and recent research by Van Kempen et al. (2022) involving 8,723 AIS patients found that declines in pulmonary function tests (PFTs) were linked to the severity of their spinal deformities.However, these clinically relevant pulmonary symptoms are not routinely monitored, which could have health implications as patie...
Source: The Keio Journal of Medicine - December 24, 2023 Category: Universities & Medical Training Authors: Marinus De Kleuver Source Type: research
Military Clinical Strategist to International Health Investor
Keio J Med. 2023;72(4):106. doi: 10.2302/kjm.ABSTRACT_72-4-1.ABSTRACTVirtual reality (VR) is emerging as a groundbreaking tool in the treatment of congenital heart diseases. This innovative technology offers a transformative approach by creating immersive, interactive, and personalized environments for both patients and healthcare professionals. In the pediatric cardiology institute in Safra Children's hospital in Sheba Medical Center in Israel, VR is being utilized for patient education, pre-operative planning, and intraoperative guidance. Patients can explore 3D visualizations of their own hearts, gaining a better unders...
Source: The Keio Journal of Medicine - December 24, 2023 Category: Universities & Medical Training Authors: Shai Tejman-Yarden Source Type: research
Pulmonary symptoms in adolescent and adult patients with a spinal deformity
Keio J Med. 2023;72(4):106. doi: 10.2302/kjm.ABSTRACT_72_4-2.ABSTRACTPatients with spinal deformities, both adolescents and adults, often experience pulmonary symptoms such as shortness of breath during physical exertion and reduced exercise tolerance. These symptoms significantly affect their daily functioning, and recent research by Van Kempen et al. (2022) involving 8,723 AIS patients found that declines in pulmonary function tests (PFTs) were linked to the severity of their spinal deformities.However, these clinically relevant pulmonary symptoms are not routinely monitored, which could have health implications as patie...
Source: The Keio Journal of Medicine - December 24, 2023 Category: Universities & Medical Training Authors: Marinus De Kleuver Source Type: research
Military Clinical Strategist to International Health Investor
Keio J Med. 2023;72(4):106. doi: 10.2302/kjm.ABSTRACT_72-4-1.ABSTRACTVirtual reality (VR) is emerging as a groundbreaking tool in the treatment of congenital heart diseases. This innovative technology offers a transformative approach by creating immersive, interactive, and personalized environments for both patients and healthcare professionals. In the pediatric cardiology institute in Safra Children's hospital in Sheba Medical Center in Israel, VR is being utilized for patient education, pre-operative planning, and intraoperative guidance. Patients can explore 3D visualizations of their own hearts, gaining a better unders...
Source: The Keio Journal of Medicine - December 24, 2023 Category: Universities & Medical Training Authors: Shai Tejman-Yarden Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
Pachyonychia Congenita Project: Advancing Research and Drug Development through Collaboration
Keio J Med. 2023 Dec 8. doi: 10.2302/kjm.2023-0015-IR. Online ahead of print.ABSTRACTPachyonychia Congenita Project (PC Project) is an international patient advocacy organization dedicated to patients who suffer from pachyonychia congenita (PC). This condition is a painful and debilitating skin disorder caused by a mutation in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16,or KRT17. Through two primary programs, namely the International Pachyonychia Congenita Consortium (IPCC) and the International Pachyonychia Congenita Research Registry (IPCRR), PC Project provides comprehensive patient support and diagnostics whi...
Source: The Keio Journal of Medicine - December 10, 2023 Category: Universities & Medical Training Authors: Janice N Schwartz Holly A Evans Edel A O'toole C David Hansen Source Type: research
