Gorlin Syndrome and Cowden Syndrome
Keio J Med. 2023 Aug 10. doi: 10.2302/kjm.2023-0010-IR. Online ahead of print.ABSTRACTGorlin syndrome and Cowden syndrome are hereditary diseases that are characterized by multiple malignancies, cutaneous symptoms, and various other abnormalities. Both disorders are caused by a mutation of the gene that regulates cell proliferation and growth, resulting in tumorigenesis. Representative mutations are mutation in the patched 1 gene (PTCH1) in Gorlin syndrome and mutation in the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) gene in Cowden syndrome. Making a diagnosis of these diseases in the early years of ...
Source: The Keio Journal of Medicine - August 9, 2023 Category: Universities & Medical Training Authors: Hiroyuki Goto Chiharu Tateishi Daisuke Tsuruta Source Type: research
Gorlin Syndrome and Cowden Syndrome
Keio J Med. 2023 Aug 10. doi: 10.2302/kjm.2023-0010-IR. Online ahead of print.ABSTRACTGorlin syndrome and Cowden syndrome are hereditary diseases that are characterized by multiple malignancies, cutaneous symptoms, and various other abnormalities. Both disorders are caused by a mutation of the gene that regulates cell proliferation and growth, resulting in tumorigenesis. Representative mutations are mutation in the patched 1 gene (PTCH1) in Gorlin syndrome and mutation in the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) gene in Cowden syndrome. Making a diagnosis of these diseases in the early years of ...
Source: The Keio Journal of Medicine - August 9, 2023 Category: Universities & Medical Training Authors: Hiroyuki Goto Chiharu Tateishi Daisuke Tsuruta Source Type: research
Gorlin Syndrome and Cowden Syndrome
Keio J Med. 2023 Aug 10. doi: 10.2302/kjm.2023-0010-IR. Online ahead of print.ABSTRACTGorlin syndrome and Cowden syndrome are hereditary diseases that are characterized by multiple malignancies, cutaneous symptoms, and various other abnormalities. Both disorders are caused by a mutation of the gene that regulates cell proliferation and growth, resulting in tumorigenesis. Representative mutations are mutation in the patched 1 gene (PTCH1) in Gorlin syndrome and mutation in the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) gene in Cowden syndrome. Making a diagnosis of these diseases in the early years of ...
Source: The Keio Journal of Medicine - August 9, 2023 Category: Universities & Medical Training Authors: Hiroyuki Goto Chiharu Tateishi Daisuke Tsuruta Source Type: research
Gorlin Syndrome and Cowden Syndrome
Keio J Med. 2023 Aug 10. doi: 10.2302/kjm.2023-0010-IR. Online ahead of print.ABSTRACTGorlin syndrome and Cowden syndrome are hereditary diseases that are characterized by multiple malignancies, cutaneous symptoms, and various other abnormalities. Both disorders are caused by a mutation of the gene that regulates cell proliferation and growth, resulting in tumorigenesis. Representative mutations are mutation in the patched 1 gene (PTCH1) in Gorlin syndrome and mutation in the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) gene in Cowden syndrome. Making a diagnosis of these diseases in the early years of ...
Source: The Keio Journal of Medicine - August 9, 2023 Category: Universities & Medical Training Authors: Hiroyuki Goto Chiharu Tateishi Daisuke Tsuruta Source Type: research
Tuberous Sclerosis Complex
This report summarizes the pathogenesis and current status of TSC and the contribution of the Neurocutaneous Syndrome Policy Research Group to the policies of the Ministry of Health, Labor, and Welfare with respect to this rare, intractable disease.PMID:37532517 | DOI:10.2302/kjm.2023-0011-IR (Source: The Keio Journal of Medicine)
Source: The Keio Journal of Medicine - August 2, 2023 Category: Universities & Medical Training Authors: Mari Wataya-Kaneda Source Type: research
Tuberous Sclerosis Complex
This report summarizes the pathogenesis and current status of TSC and the contribution of the Neurocutaneous Syndrome Policy Research Group to the policies of the Ministry of Health, Labor, and Welfare with respect to this rare, intractable disease.PMID:37532517 | DOI:10.2302/kjm.2023-0011-IR (Source: The Keio Journal of Medicine)
Source: The Keio Journal of Medicine - August 2, 2023 Category: Universities & Medical Training Authors: Mari Wataya-Kaneda Source Type: research
Tuberous Sclerosis Complex
This report summarizes the pathogenesis and current status of TSC and the contribution of the Neurocutaneous Syndrome Policy Research Group to the policies of the Ministry of Health, Labor, and Welfare with respect to this rare, intractable disease.PMID:37532517 | DOI:10.2302/kjm.2023-0011-IR (Source: The Keio Journal of Medicine)
Source: The Keio Journal of Medicine - August 2, 2023 Category: Universities & Medical Training Authors: Mari Wataya-Kaneda Source Type: research
Tuberous Sclerosis Complex
This report summarizes the pathogenesis and current status of TSC and the contribution of the Neurocutaneous Syndrome Policy Research Group to the policies of the Ministry of Health, Labor, and Welfare with respect to this rare, intractable disease.PMID:37532517 | DOI:10.2302/kjm.2023-0011-IR (Source: The Keio Journal of Medicine)
Source: The Keio Journal of Medicine - August 2, 2023 Category: Universities & Medical Training Authors: Mari Wataya-Kaneda Source Type: research
Tuberous Sclerosis Complex
This report summarizes the pathogenesis and current status of TSC and the contribution of the Neurocutaneous Syndrome Policy Research Group to the policies of the Ministry of Health, Labor, and Welfare with respect to this rare, intractable disease.PMID:37532517 | DOI:10.2302/kjm.2023-0011-IR (Source: The Keio Journal of Medicine)
Source: The Keio Journal of Medicine - August 2, 2023 Category: Universities & Medical Training Authors: Mari Wataya-Kaneda Source Type: research
Tuberous Sclerosis Complex
This report summarizes the pathogenesis and current status of TSC and the contribution of the Neurocutaneous Syndrome Policy Research Group to the policies of the Ministry of Health, Labor, and Welfare with respect to this rare, intractable disease.PMID:37532517 | DOI:10.2302/kjm.2023-0011-IR (Source: The Keio Journal of Medicine)
Source: The Keio Journal of Medicine - August 2, 2023 Category: Universities & Medical Training Authors: Mari Wataya-Kaneda Source Type: research
Senso-immunology: The Emerging Connection between Pain and Immunity
Keio J Med. 2023 Jul 15. doi: 10.2302/kjm.2022-0037-IR. Online ahead of print.ABSTRACTThe sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune systems and have found that inflammation and bone destruction caused by fungal infection are suppressed by nociceptors. Furthermore, we have elucidated the molecular mechanism whereby fungal receptors are expressed on nociceptors and skin epithelium, how they cooperate to generate fungal pain, and how ...
Source: The Keio Journal of Medicine - July 17, 2023 Category: Universities & Medical Training Authors: Kenta Maruyama Source Type: research
Senso-immunology: The Emerging Connection between Pain and Immunity
Keio J Med. 2023 Jul 15. doi: 10.2302/kjm.2022-0037-IR. Online ahead of print.ABSTRACTThe sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune systems and have found that inflammation and bone destruction caused by fungal infection are suppressed by nociceptors. Furthermore, we have elucidated the molecular mechanism whereby fungal receptors are expressed on nociceptors and skin epithelium, how they cooperate to generate fungal pain, and how ...
Source: The Keio Journal of Medicine - July 17, 2023 Category: Universities & Medical Training Authors: Kenta Maruyama Source Type: research
Senso-immunology: The Emerging Connection between Pain and Immunity
Keio J Med. 2023 Jul 15. doi: 10.2302/kjm.2022-0037-IR. Online ahead of print.ABSTRACTThe sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune systems and have found that inflammation and bone destruction caused by fungal infection are suppressed by nociceptors. Furthermore, we have elucidated the molecular mechanism whereby fungal receptors are expressed on nociceptors and skin epithelium, how they cooperate to generate fungal pain, and how ...
Source: The Keio Journal of Medicine - July 17, 2023 Category: Universities & Medical Training Authors: Kenta Maruyama Source Type: research
Senso-immunology: The Emerging Connection between Pain and Immunity
Keio J Med. 2023 Jul 15. doi: 10.2302/kjm.2022-0037-IR. Online ahead of print.ABSTRACTThe sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune systems and have found that inflammation and bone destruction caused by fungal infection are suppressed by nociceptors. Furthermore, we have elucidated the molecular mechanism whereby fungal receptors are expressed on nociceptors and skin epithelium, how they cooperate to generate fungal pain, and how ...
Source: The Keio Journal of Medicine - July 17, 2023 Category: Universities & Medical Training Authors: Kenta Maruyama Source Type: research
Senso-immunology: The Emerging Connection between Pain and Immunity
Keio J Med. 2023 Jul 15. doi: 10.2302/kjm.2022-0037-IR. Online ahead of print.ABSTRACTThe sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune systems and have found that inflammation and bone destruction caused by fungal infection are suppressed by nociceptors. Furthermore, we have elucidated the molecular mechanism whereby fungal receptors are expressed on nociceptors and skin epithelium, how they cooperate to generate fungal pain, and how ...
Source: The Keio Journal of Medicine - July 17, 2023 Category: Universities & Medical Training Authors: Kenta Maruyama Source Type: research
