Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease
Keio J Med. 2023 Jun 3. doi: 10.2302/kjm.2022-0017-IR. Online ahead of print.ABSTRACTThe number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integral part of the primary filtration unit of the kidney and form a slit membrane as a barrier to prevent proteinuria. The role of podocytes in the pathogenesis and progression of CKD is now recognized. Podocyte function depends on a specialized morphology with the arranged foot processes, which is directly...
Source: The Keio Journal of Medicine - June 4, 2023 Category: Universities & Medical Training Authors: Kaori Hayashi Source Type: research
The Unlikely Development of CAR T Cells: a Brief History and Prospects for the Future
Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have prec...
Source: The Keio Journal of Medicine - March 26, 2023 Category: Universities & Medical Training Authors: Carl H June Source Type: research
Addressing the Threat of Emerging Viral Infections
Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique ...
Source: The Keio Journal of Medicine - March 26, 2023 Category: Universities & Medical Training Authors: Yoshihiro Kawaoka Source Type: research
The Unlikely Development of CAR T Cells: a Brief History and Prospects for the Future
Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have prec...
Source: The Keio Journal of Medicine - March 26, 2023 Category: Universities & Medical Training Authors: Carl H June Source Type: research
Addressing the Threat of Emerging Viral Infections
Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique ...
Source: The Keio Journal of Medicine - March 26, 2023 Category: Universities & Medical Training Authors: Yoshihiro Kawaoka Source Type: research
The Unlikely Development of CAR T Cells: a Brief History and Prospects for the Future
Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have prec...
Source: The Keio Journal of Medicine - March 26, 2023 Category: Universities & Medical Training Authors: Carl H June Source Type: research
