Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation
CONCLUSION AND RELEVANCE: A trend toward increased PGD was present in patients receiving preoperative amiodarone. This finding combined with the regression showing significantly increased odds of PGD with increasing 3 and 6 month cumulative amiodarone dose is clinically concerning. Escalation of care with pacemaker implantation was required more frequently in patients on pre-OHT amiodarone.PMID:38361242 | DOI:10.1177/10600280241232032 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 16, 2024 Category: Drugs & Pharmacology Authors: Abigail Servais Scott Lundgren Stephanie Bowman Douglas Stoller Adam Burdorf Marshall Hyden Brian Lowes Ronald Zolty Don Klepser Heidi Brink Source Type: research
Evaluation of Short Versus Long Courses of Antibiotics in Critically Ill Patients With Gram-Negative Bloodstream Infections
CONCLUSION AND RELEVANCE: In critically ill patients with GN-BSI, there were no efficacy outcome differences in patients treated with a short course of antibiotics compared with longer. However, patients in the short group were less likely to experience ADE. These findings suggest that short courses of antibiotics are effective for GN-BSI in critically ill patients.PMID:38347703 | DOI:10.1177/10600280241231611 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2024 Category: Drugs & Pharmacology Authors: Daniel T Anderson Divisha Sharma Aaron M Chase Zoheb Irshad Sulaiman August H Anderson Ashley L Huggett Joshua Eudy Source Type: research
Exploring Safety in Gender-Affirming Hormonal Treatments: An Observational Study on Adverse Drug Events Using the Food and Drug Administration Adverse Event Reporting System Database
CONCLUSIONS AND RELEVANCE: The FAERS data reveal significant ADRs in transgender individuals using hormone therapy, sometimes unintended for their recipient gender. Population-level studies are crucial to enhance transgender health care. Spontaneous surveillance databases like FAERS illuminate off-label ADRs, urging health care providers to approach hormone therapies with informed caution.PMID:38347713 | DOI:10.1177/10600280241231612 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2024 Category: Drugs & Pharmacology Authors: Ainhoa Gomez-Lumbreras Lorenzo Villa-Zapata Source Type: research
Evaluation of Short Versus Long Courses of Antibiotics in Critically Ill Patients With Gram-Negative Bloodstream Infections
CONCLUSION AND RELEVANCE: In critically ill patients with GN-BSI, there were no efficacy outcome differences in patients treated with a short course of antibiotics compared with longer. However, patients in the short group were less likely to experience ADE. These findings suggest that short courses of antibiotics are effective for GN-BSI in critically ill patients.PMID:38347703 | DOI:10.1177/10600280241231611 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2024 Category: Drugs & Pharmacology Authors: Daniel T Anderson Divisha Sharma Aaron M Chase Zoheb Irshad Sulaiman August H Anderson Ashley L Huggett Joshua Eudy Source Type: research
Exploring Safety in Gender-Affirming Hormonal Treatments: An Observational Study on Adverse Drug Events Using the Food and Drug Administration Adverse Event Reporting System Database
CONCLUSIONS AND RELEVANCE: The FAERS data reveal significant ADRs in transgender individuals using hormone therapy, sometimes unintended for their recipient gender. Population-level studies are crucial to enhance transgender health care. Spontaneous surveillance databases like FAERS illuminate off-label ADRs, urging health care providers to approach hormone therapies with informed caution.PMID:38347713 | DOI:10.1177/10600280241231612 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2024 Category: Drugs & Pharmacology Authors: Ainhoa Gomez-Lumbreras Lorenzo Villa-Zapata Source Type: research
Real-World Incidence and Severity of Hypertension Caused by Abiraterone Acetate in Patients With Metastatic Prostate Cancer
CONCLUSION AND RELEVANCE: This single-center, retrospective cohort study found that real-world metastatic prostate cancer patients who received AA had substantially higher incidence and severity of hypertension compared with clinical trials regardless of prednisone dose. In patients with mCRPC and mCSPC, the role of prednisone dose in hypertension incidence and severity warrants further investigation. Overall, results indicate the need for closely monitoring hypertension and optimization of anti-hypertensive therapy by multidisciplinary teams in metastatic prostate cancer patients receiving AA.PMID:38344981 | DOI:10.1177/1...
Source: The Annals of Pharmacotherapy - February 12, 2024 Category: Drugs & Pharmacology Authors: Brian Lam Jo E Rodgers Benyam Muluneh Darrian Proco Young E Whang Katherine P Morgan Source Type: research
Mirikizumab: A New Therapeutic Option for the Treatment of Ulcerative Colitis
CONCLUSION: Mirikizumab provides a novel mechanism of action for the treatment of moderate to severe UC and is another welcomed treatment advance in the treatment arsenal, providing a more selective mechanism of action while maintaining a comparable safety profile.PMID:38344998 | DOI:10.1177/10600280241229742 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 12, 2024 Category: Drugs & Pharmacology Authors: David Choi Hilary Sheridan Shubha Bhat Source Type: research
The Impact of Glycemic Control on Sodium-Glucose Co-Transporter 2 Inhibitor-Associated Genitourinary Infections
CONCLUSIONS AND RELEVANCE: Type 2 diabetes patients initiated on SGLT2is may experience an increased risk of GU infection, especially in those patients with an A1C of 9% or greater. Further research is necessary to validate and expand upon these findings.PMID:38321772 | DOI:10.1177/10600280241227973 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 7, 2024 Category: Drugs & Pharmacology Authors: Anthony Gerber Victoria Rupp Natalia Ryabenkova Nataliya Mikhelzon Source Type: research
Clinical Response to Third-Line Angiotensin-II vs Epinephrine in Septic Shock: A Propensity-Matched Cohort Study
CONCLUSIONS AND RELEVANCE: Administration of AT-II as a third-line vasopressor agent in septic shock patients was not associated with significantly improved clinical response at hour 24 compared with epinephrine. Although underpowered to detect meaningful differences, the clinical observations of this study warrant consideration and further investigation of AT-II as a third-line vasopressor in septic shock.PMID:38303571 | DOI:10.1177/10600280231226132 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 2, 2024 Category: Drugs & Pharmacology Authors: Caitlyn R Blankenship Kevin D Betthauser Laura N Hencken Julie A Maamari Jenna Goetz Bria D Giacomino Gabrielle A Gibson Source Type: research
Evaluation of a Pharmacist-Led Implementation of Standardized Medication Administration Times for Inpatients Receiving Hemodialysis
CONCLUSION AND RELEVANCE: A pharmacist-led intervention for standard medication administration times in patients requiring hemodialysis increased the number of prescribed medication doses given and given on time. The intervention also led to more antimicrobials administered at appropriate times relative to dialysis sessions.PMID:38293819 | DOI:10.1177/10600280231220079 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 31, 2024 Category: Drugs & Pharmacology Authors: Abbie L Blunier Megan R Cheatham Karishma S Deodhar Christopher A Geik Todd A Walroth Jessica A Whitten Christie M Davis Source Type: research
Monoclonal Antibody Infusions for Outpatient Management of Mild-Moderate COVID-19
CONCLUSION AND RELEVANCE: Overall, the mAbs appeared safe and effective. Sicker, higher-risk mAb-treated veterans faired similarly to less-sick, high-risk veterans not treated. Those who were vaccinated seemed to benefit the most from mAb therapy. Future prospective studies with more matched groups are needed to assess full benefits and risks of mAbs shown to neutralize the predominant variants.PMID:38288555 | DOI:10.1177/10600280231222465 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 30, 2024 Category: Drugs & Pharmacology Authors: Hannah B Knox Lisa A Dykes Lancer A Scott Bradley C Presley Lara C Lambert Source Type: research
Epidemiology of Vancomycin in Combination With Piperacillin/Tazobactam-Associated Acute Kidney Injury in Children: A Systematic Review and Meta-analysis
CONCLUSIONS: The incidence of VPT-associated AKI in children is high, especially in critically ill children. Medication regimens should be personalized based on the presence of individual risk factors. Moreover, renal function was regularly assessed throughout treatment with VPT.PMID:38279799 | DOI:10.1177/10600280231220379 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 27, 2024 Category: Drugs & Pharmacology Authors: Miao Zhang Liang Huang Yu Zhu Linan Zeng Zhi-Jun Jia Guo Cheng Hailong Li Lingli Zhang Source Type: research
