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CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Voriconazole in Chinese Kidney Transplant Patients
CONCLUSION AND RELEVANCE: The median C0/D values were 90.38% higher in kidney transplant recipients with CYP3A5*3/*3 genotype than in those with CYP3A5*1/*1 or CYP3A5*1/*3 genotype when treated with both tacrolimus and voriconazole. A CYP3A5 genotype-dependent DDI was found between tacrolimus and voriconazole. Therefore, personalized therapy accounting for CYP3A5 genotype detection and therapeutic drug monitoring is necessary for kidney transplant patients when treating with tacrolimus and voriconazole.PMID:37702380 | DOI:10.1177/10600280231197399 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 13, 2023 Category: Drugs & Pharmacology Authors: Yundi Zhang Yue Du Shuyu Ren Yue Li Xiaoming Zhang Xiaohong Cao Fengxi Liu Huiying Zong Yan Li Source Type: research

Intranasal Theophylline: Potential Treatment for Long COVID Olfactory Dysfunction?
Ann Pharmacother. 2023 Sep 7:10600280231194960. doi: 10.1177/10600280231194960. Online ahead of print.NO ABSTRACTPMID:37675960 | DOI:10.1177/10600280231194960 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 7, 2023 Category: Drugs & Pharmacology Authors: Olga Hilas Tina Caliendo Source Type: research