Trimethoprim/Sulfamethoxazole vs Minocycline for the Treatment of Nonurinary Monomicrobial < em > Stenotrophomonas maltophilia < /em > Infections in Hospitalized Patients
CONCLUSIONS AND RELEVANCE: Rates of clinical failure, clinical improvement, or clinical success were similar between MIN and SXT for nonurinary monomicrobial S. maltophilia infections.PMID:37776160 | DOI:10.1177/10600280231201850 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Emma C Hevia Leslie Wooten Amy L Carr Source Type: research
Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury
CONCLUSION AND RELEVANCE: Neurocritically ill patients exhibit rapid levetiracetam clearance resulting in a short elimination half-life. Findings of this study suggest regimens of levetiracetam 500 mg every 6 hours, 1000 mg every 8 hours, or 2000 mg every 12 hours may be required for optimal therapeutic target attainment. Patient weight of 75 kg may serve as a breakpoint for weight-guided dosing to optimize levetiracetam therapeutic target attainment for seizure prophylaxis.PMID:37776163 | DOI:10.1177/10600280231202246 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Sarah Schuman Harlan Carolyn D Philpott Shaun P Keegan Molly E Droege Aniruddha S Karve Brandon Foreman Devin Wakefield Eric W Mueller Kiranpal Sangha Laura B Ngwenya Joshua D Courter Pankaj Desai Christopher Droege Source Type: research
The Impact of Ketamine for Treatment of Post-Traumatic Stress Disorder: A Systematic Review With Meta-Analyses
CONCLUSIONS AND RELEVANCE: Ketamine modestly reduced PTSD and depression scores as early as 1 day of therapy, but the longevity of effect needs to be determined. Given similar magnitude of benefit with SSRIs and venlafaxine, ketamine would not supplant these traditional options for chronic use.PMID:37776285 | DOI:10.1177/10600280231199666 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Dakota J Sicignano Ryan Kurschner Nissen Weisman Ava Sedensky Adrian V Hernandez C Michael White Source Type: research
Trimethoprim/Sulfamethoxazole vs Minocycline for the Treatment of Nonurinary Monomicrobial < em > Stenotrophomonas maltophilia < /em > Infections in Hospitalized Patients
CONCLUSIONS AND RELEVANCE: Rates of clinical failure, clinical improvement, or clinical success were similar between MIN and SXT for nonurinary monomicrobial S. maltophilia infections.PMID:37776160 | DOI:10.1177/10600280231201850 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Emma C Hevia Leslie Wooten Amy L Carr Source Type: research
Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury
CONCLUSION AND RELEVANCE: Neurocritically ill patients exhibit rapid levetiracetam clearance resulting in a short elimination half-life. Findings of this study suggest regimens of levetiracetam 500 mg every 6 hours, 1000 mg every 8 hours, or 2000 mg every 12 hours may be required for optimal therapeutic target attainment. Patient weight of 75 kg may serve as a breakpoint for weight-guided dosing to optimize levetiracetam therapeutic target attainment for seizure prophylaxis.PMID:37776163 | DOI:10.1177/10600280231202246 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Sarah Schuman Harlan Carolyn D Philpott Shaun P Keegan Molly E Droege Aniruddha S Karve Brandon Foreman Devin Wakefield Eric W Mueller Kiranpal Sangha Laura B Ngwenya Joshua D Courter Pankaj Desai Christopher Droege Source Type: research
The Impact of Ketamine for Treatment of Post-Traumatic Stress Disorder: A Systematic Review With Meta-Analyses
CONCLUSIONS AND RELEVANCE: Ketamine modestly reduced PTSD and depression scores as early as 1 day of therapy, but the longevity of effect needs to be determined. Given similar magnitude of benefit with SSRIs and venlafaxine, ketamine would not supplant these traditional options for chronic use.PMID:37776285 | DOI:10.1177/10600280231199666 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Dakota J Sicignano Ryan Kurschner Nissen Weisman Ava Sedensky Adrian V Hernandez C Michael White Source Type: research
Trimethoprim/Sulfamethoxazole vs Minocycline for the Treatment of Nonurinary Monomicrobial < em > Stenotrophomonas maltophilia < /em > Infections in Hospitalized Patients
CONCLUSIONS AND RELEVANCE: Rates of clinical failure, clinical improvement, or clinical success were similar between MIN and SXT for nonurinary monomicrobial S. maltophilia infections.PMID:37776160 | DOI:10.1177/10600280231201850 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Emma C Hevia Leslie Wooten Amy L Carr Source Type: research
Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury
CONCLUSION AND RELEVANCE: Neurocritically ill patients exhibit rapid levetiracetam clearance resulting in a short elimination half-life. Findings of this study suggest regimens of levetiracetam 500 mg every 6 hours, 1000 mg every 8 hours, or 2000 mg every 12 hours may be required for optimal therapeutic target attainment. Patient weight of 75 kg may serve as a breakpoint for weight-guided dosing to optimize levetiracetam therapeutic target attainment for seizure prophylaxis.PMID:37776163 | DOI:10.1177/10600280231202246 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Sarah Schuman Harlan Carolyn D Philpott Shaun P Keegan Molly E Droege Aniruddha S Karve Brandon Foreman Devin Wakefield Eric W Mueller Kiranpal Sangha Laura B Ngwenya Joshua D Courter Pankaj Desai Christopher Droege Source Type: research
The Impact of Ketamine for Treatment of Post-Traumatic Stress Disorder: A Systematic Review With Meta-Analyses
CONCLUSIONS AND RELEVANCE: Ketamine modestly reduced PTSD and depression scores as early as 1 day of therapy, but the longevity of effect needs to be determined. Given similar magnitude of benefit with SSRIs and venlafaxine, ketamine would not supplant these traditional options for chronic use.PMID:37776285 | DOI:10.1177/10600280231199666 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Dakota J Sicignano Ryan Kurschner Nissen Weisman Ava Sedensky Adrian V Hernandez C Michael White Source Type: research
Treatment Outcomes for Carbapenem-Resistant and Cephalosporin-Susceptible < em > Pseudomonas aeruginosa < /em > Pneumonia
CONCLUSION AND RELEVANCE: For the treatment of Car-R Ceph-S P. aeruginosa pneumonia, cefepime showed similar rates of 30-day in-hospital mortality and clinical outcomes when compared to other susceptible therapies. Cefepime may be utilized to conserve novel β-lactam and β-lactamase inhibitors.PMID:37752788 | DOI:10.1177/10600280231201953 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 27, 2023 Category: Drugs & Pharmacology Authors: Tsz Hin Ng Jing J Zhao Ryan Gumbleton Shannon Olson Stephanie Smith Marco R Scipione Source Type: research
Treatment Outcomes for Carbapenem-Resistant and Cephalosporin-Susceptible < em > Pseudomonas aeruginosa < /em > Pneumonia
CONCLUSION AND RELEVANCE: For the treatment of Car-R Ceph-S P. aeruginosa pneumonia, cefepime showed similar rates of 30-day in-hospital mortality and clinical outcomes when compared to other susceptible therapies. Cefepime may be utilized to conserve novel β-lactam and β-lactamase inhibitors.PMID:37752788 | DOI:10.1177/10600280231201953 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 27, 2023 Category: Drugs & Pharmacology Authors: Tsz Hin Ng Jing J Zhao Ryan Gumbleton Shannon Olson Stephanie Smith Marco R Scipione Source Type: research
Treatment Outcomes for Carbapenem-Resistant and Cephalosporin-Susceptible < em > Pseudomonas aeruginosa < /em > Pneumonia
CONCLUSION AND RELEVANCE: For the treatment of Car-R Ceph-S P. aeruginosa pneumonia, cefepime showed similar rates of 30-day in-hospital mortality and clinical outcomes when compared to other susceptible therapies. Cefepime may be utilized to conserve novel β-lactam and β-lactamase inhibitors.PMID:37752788 | DOI:10.1177/10600280231201953 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 27, 2023 Category: Drugs & Pharmacology Authors: Tsz Hin Ng Jing J Zhao Ryan Gumbleton Shannon Olson Stephanie Smith Marco R Scipione Source Type: research
Treatment Outcomes for Carbapenem-Resistant and Cephalosporin-Susceptible < em > Pseudomonas aeruginosa < /em > Pneumonia
CONCLUSION AND RELEVANCE: For the treatment of Car-R Ceph-S P. aeruginosa pneumonia, cefepime showed similar rates of 30-day in-hospital mortality and clinical outcomes when compared to other susceptible therapies. Cefepime may be utilized to conserve novel β-lactam and β-lactamase inhibitors.PMID:37752788 | DOI:10.1177/10600280231201953 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 27, 2023 Category: Drugs & Pharmacology Authors: Tsz Hin Ng Jing J Zhao Ryan Gumbleton Shannon Olson Stephanie Smith Marco R Scipione Source Type: research
Real-world Impact of 3 and 4.5 mg Doses of Dulaglutide on Weight and Hemoglobin A1c in Patients With Type 2 Diabetes Mellitus
CONCLUSION AND RELEVANCE: Titration from dulaglutide 1.5 to 3 mg resulted in significant reductions in weight and HbA1c after 24 weeks. Additional, statistically significant, reductions in weight and HbA1c were seen when patients were further titrated to dulaglutide 4.5 mg weekly.PMID:37743669 | DOI:10.1177/10600280231199852 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 25, 2023 Category: Drugs & Pharmacology Authors: Amy Duong Samantha Heacock Sarah Amering Lillian Brennan Jineane Venci Nicole M Acquisto Source Type: research
Keeping It "Current": A Review of Treatment Options for the Management of Supraventricular Tachycardia
CONCLUSIONS: With high annual rates of ED visits for SVT, providers should be aware of the data behind management and modifications of therapy based on patient-specific factors (ie, patient preference, pharmacokinetics/pharmacodynamics, drug interactions, and special populations).PMID:37743672 | DOI:10.1177/10600280231199136 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 25, 2023 Category: Drugs & Pharmacology Authors: Patrick Tednes Samantha Marquardt Shannon Kuhrau Kristin Heagler Megan Rech Source Type: research
