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Blind Spots in Development of Nanomedicines
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241245342. doi: 10.1177/15330338241245342.ABSTRACTThe field of nanomedicine demonstrates immense advantages and noteworthy expansion compared to conventional drug delivery systems like tablet, capsules, etc. Despite the innumerable advantages, it holds certain shortcomings in the form of blind spots that need to be assessed before the successful clinical translation. This perspective highlights the foremost blind spots in nanomedicine and emphasizes the challenges faced before the entry into the market, including the need for provision of safety and efficacy data by the reg...
Source: Technology in Cancer Research and Treatment - April 3, 2024 Category: Cancer & Oncology Authors: Bhagyashree V Salvi Maithali Kantak Kalyani Kharangate Francesco Trotta Timothy Maher Pravin Shende Source Type: research

Correlation Between ImageJ and Conventional Manual Scoring Methods for Programmed Death-Ligand 1 Immuno-Histochemically Stained Sections
Conclusion: ImageJ can be used to score homogeneous tissues. In the case of highly heterogeneous tissues, it is advised to use the conventional method rather than ImageJ scoring.PMID:38562094 | DOI:10.1177/15330338241242635 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 2, 2024 Category: Cancer & Oncology Authors: Rand Suleiman Al Taher Manal A Abbas Khalid Halahleh Maher A Sughayer Source Type: research

Combined OLA1 and CLEC3B Gene Is a Prognostic Signature for Hepatocellular Carcinoma and Impact Tumor Progression
In this study, mRNA sequencing expression profiles and relevant clinical data of HCC patients were gathered from different public databases. Kaplan-Meier survival curves as well as ROC curves validated that OLA1|CLEC3B was an independent predictor with better predictive capability of HCC prognosis compared to OLA1 and CLEC3B separately. Further, the cell transfection experiment verified that knockdown of OLA1 inhibited cell proliferation, facilitated apoptosis, and improved sensitivity of HCC cells to gemcitabine. In this study, the prognostic model of HCC composed of OLA1/CLEC3B genes was constructed and verified, and the...
Source: Technology in Cancer Research and Treatment - April 2, 2024 Category: Cancer & Oncology Authors: Zhoufeng Chen Liuwei Zeng Zhuoyan Chen Jun Xu Xiangting Zhang Huiya Ying Yuan Zeng Fujun Yu Source Type: research

Feasibility of Customized Thermoplastic Patient-Specific Helmet Bolus for Scalp Irradiation Using Volumetric-Modulated Arc Therapy Planning
Conclusion: This study proposed a method to fabricate patient-specific boluses that are highly reproducible, accessible, and easy to fabricate for radiotherapy to the entire scalp and can effectively spare normal tissue while delivering sufficient surface dose.PMID:38557213 | DOI:10.1177/15330338241241898 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 1, 2024 Category: Cancer & Oncology Authors: Heesoo Kim Jeong-Woo Lee Semie Hong Source Type: research

Peripheral Doses Beyond Electron Applicators in Conventional C-Arm Linear Accelerators: A Systematic Literature Review
Conclusion: The literature emphasizes importance of precision in electron beam radiation therapy, highlighting the critical need for managing peripheral doses and optimizing hardware to ensure patient safety. It advocates for the use of advanced tools and protocols to maintain a balance between effective treatment while protecting healthy tissues. Continuous research, careful treatment planning, and effective management of peripheral doses are essential.PMID:38515394 | PMC:PMC10958816 | DOI:10.1177/15330338241239144 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 22, 2024 Category: Cancer & Oncology Authors: Kapil Dev Maharaj Joshua Dass Mounir Ibrahim Talat Mahmood Pejman Rowshanfarzad Source Type: research

Determination of < em > In Vitro < /em > and < em > In Vivo < /em > Effects of Taxifolin and Epirubicin on Epithelial-Mesenchymal Transition in Mouse Breast Cancer Cells
Conclusion: The in vitro and in vivo results of our study indicate that the concurrent use of Epirubicin with Taxifolin has supportive effects on breast cancer treatment.PMID:38515396 | PMC:PMC10958820 | DOI:10.1177/15330338241241245 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 22, 2024 Category: Cancer & Oncology Authors: Muhammet Ocak Duygu Deniz Usta Gokce Nur Arik Erol Gulnur Take Kaplanoglu Ece Konac Atiye Seda Yar Saglam Source Type: research