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Integrating Therapeutic Ultrasound With Nanosized Drug Delivery Systems in the Battle Against Cancer
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231211472. doi: 10.1177/15330338231211472.ABSTRACTControlled, localized, and timely activation of nanosized drug delivery systems (NSDDSs), using an external stimulus such as therapeutic ultrasound (TUS), can improve the efficacy of cancer treatments compared to either conventional chemotherapy methods or passive NSDDSs alone. Specifically, TUS induces thermal and mechanical effects that trigger drug release from NSDDSs and overcomes drug delivery barriers in tumor microenvironments to allow nanoparticle drug carriers to penetrate more deeply into tumor tissue while minimiz...
Source: Technology in Cancer Research and Treatment - November 10, 2023 Category: Cancer & Oncology Authors: None Moradi Kashkooli Anshuman Jakhmola Graham A Ferrier Tyler K Hornsby Jahangir Jahan Tavakkoli Michael C Kolios Source Type: research

Meta-analysis of the Prognostic Value of microRNA-22 in Leukemia Patients
Conclusions: miR-22 is associated with the survival outcome of leukemia patients suggesting that miR-22 may be a promising prognostic biomarker for this patient population, and the expression level of miR-22 in ALL patients down-regulated.PMID:37942522 | DOI:10.1177/15330338231212309 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - November 9, 2023 Category: Cancer & Oncology Authors: Jing Xia Daming Xu Yuanling Qin Faguang Wan Yongwei Ren Chaozhi Bu Tianyu Li Source Type: research

Exosomal microRNA Therapy for Non-Small-Cell Lung Cancer
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231210731. doi: 10.1177/15330338231210731.ABSTRACTWith the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be related to disease diagnosis, diagnosis of treatment resistance, prediction of prognosis, and drugs for treatment. To date, nine target mRNA/signal pathways have been confirmed for microRNA drug therapy both in vitro and in vivo. When microRNA drugs enter blood vessels, they target the tumor site and play a similar role to that of targeted drugs. However, whether they wi...
Source: Technology in Cancer Research and Treatment - November 8, 2023 Category: Cancer & Oncology Authors: Jibing Chen Fasheng Wu Encun Hou Jianying Zeng Fujun Li Hongjun Gao Source Type: research

Preoperative and Prognostic Prediction of Microvascular Invasion in Hepatocellular Carcinoma: A Review Based on Artificial Intelligence
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231212726. doi: 10.1177/15330338231212726.ABSTRACTMicrovascular invasion of hepatocellular carcinoma is an important factor affecting tumor recurrence after liver resection and liver transplantation. There are many ways to classify microvascular invasion, however, an international consensus is urgently needed. Recently, artificial intelligence has emerged as an important tool for improving the clinical management of hepatocellular carcinoma. Many studies about microvascular invasion currently focus on preoperative and prognosis prediction of microvascular invasion using art...
Source: Technology in Cancer Research and Treatment - November 7, 2023 Category: Cancer & Oncology Authors: Yu Jiang Kang Wang Yu-Ran Wang Yan-Jun Xiang Zong-Han Liu Jin-Kai Feng Shu-Qun Cheng Source Type: research

Docetaxel Plus Nedaplatin or Carboplatin as Second-Line Chemotherapy for Advanced Lung Squamous Cell Carcinoma in Real-World Practice: A Single-Center Experience
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231206334. doi: 10.1177/15330338231206334.ABSTRACTAlthough single-drug chemotherapy regimens were used as second-line chemotherapy for advanced lung squamous cell carcinoma (LSCC) patients, there are still no standard guidelines for second-line chemotherapy. The purpose of this study was to compare the efficacy and safety of docetaxel combined with nedaplatin or carboplatin in the second-line treatment of advanced LSCC patients. One hundred and ninety-six LSCC patients receiving docetaxel plus nedaplatin (DN, n = 96) or carboplatin (DC, n = 100) were retrospectively collect...
Source: Technology in Cancer Research and Treatment - November 6, 2023 Category: Cancer & Oncology Authors: Jian Zhong Qian Zhang Li Li ChunHua Xu Source Type: research

Effects of Adjuvant Radiation Plus Chemotherapy on Survival Outcomes in Stage III C Endometrial Cancer According to Histology: Analysis of Data from the Surveillance, Epidemiology, and End Results Database
Conclusion: For patients with stage IIIC endometrial cancer, combined treatment with radiation and chemotherapy was associated with improved OS compared with chemotherapy alone. However, no survival benefit was found, and radiotherapy may be unnecessary in patients with low-grade endometrioids.PMID:37926997 | DOI:10.1177/15330338231208610 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - November 6, 2023 Category: Cancer & Oncology Authors: Junna Kou Guangwei Yan Lin Xiao Na Wei Huayan Ren Jingjing Xu Source Type: research

SGMS1-AS1/MicroRNA-106a-5p/CPT2 Axis as a Novel Target for Regulating Lactate Metabolism in Colon Cancer
CONCLUSION: Our work revealed the possible mechanism of lactate accumulation in colon cancer and explored a new potential treatment for colon cancer by cutting off aerobic glycolysis in tumor cells.PMID:37926998 | DOI:10.1177/15330338231212071 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - November 6, 2023 Category: Cancer & Oncology Authors: Yan Ruochen Ji Wenbin Gao Chao Yuan Yuhua Qi Feng Source Type: research

The Predictive Model Construction for Immune-Related Adverse Events in Non-Small Cell Lung Cancer Patients Receiving Immunotherapy
CONCLUSION: Our study identified the risk factors related to irAEs occurrence and constructed and assessed the predictive model of irAEs in patients with NSCLC treated by ICIs using clinical and hematological parameters, thus guiding clinicians to select precisely the population receiving immunotherapy and develop individualized treatment therapy.PMID:37927008 | DOI:10.1177/15330338231206705 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - November 6, 2023 Category: Cancer & Oncology Authors: Weitong Gao Qianqian Liu Yang Zhou Min Yang Yan Yu Source Type: research

Exploration of an Prognostic Signature Related to Endoplasmic Reticulum Stress in Colorectal Adenocarcinoma and Their Response Targeting Immunotherapy
Conclusion: Our study established a novel risk signature to predict the COAD prognosis of patients and provide theoretical support for the clinical treatment of COAD.PMID:37920989 | PMC:PMC10623925 | DOI:10.1177/15330338231212073 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - November 3, 2023 Category: Cancer & Oncology Authors: Yu Xu Yang-Mei Xie Wen-Sha Sun Rong Zi Hong-Qiao Lu Le Xiao Kun-Mei Gong Shi-Kui Guo Source Type: research

Exploration of an Prognostic Signature Related to Endoplasmic Reticulum Stress in Colorectal Adenocarcinoma and Their Response Targeting Immunotherapy
Conclusion: Our study established a novel risk signature to predict the COAD prognosis of patients and provide theoretical support for the clinical treatment of COAD.PMID:37920989 | DOI:10.1177/15330338231212073 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - November 3, 2023 Category: Cancer & Oncology Authors: Yu Xu Yang-Mei Xie Wen-Sha Sun Rong Zi Hong-Qiao Lu Le Xiao Kun-Mei Gong Shi-Kui Guo Source Type: research

Research Progress of Immuno-Inhibitory Receptors in Gynecological Cervical Cancer
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231208846. doi: 10.1177/15330338231208846.ABSTRACTThe mortality rate of cervical cancer is the highest among female malignant tumors and seriously threatens women's lives and health. Persistent high-risk human papillomavirus (HPV) infection is the leading cause of cervical cancer, which provides the basis for immunotherapy. In recent years, owing to progress in targeted therapy and immunotherapy, the survival time of patients with cervical cancer has been significantly extended. However, effective treatments for advanced, recurrent, and metastatic cancers are lacking. "Tumo...
Source: Technology in Cancer Research and Treatment - November 1, 2023 Category: Cancer & Oncology Authors: Yang Li Fangrong Shen Qingqing Tan Youguo Chen Yanzheng Gu Source Type: research