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Elevated INHBA Promotes Tumor Progression of Cervical Cancer
Conclusion: In conclusion, our findings suggest that INHBA plays a crucial role in the progression of cervical cancer. The upregulation of INHBA is associated with poor patient survival, and its involvement in promoting key aspects of cancer progression makes it a potential therapeutic target for CCa treatment. These results provide valuable insights into the molecular mechanisms underlying CCa and offer a foundation for further exploration of targeted therapeutic interventions.PMID:38419562 | PMC:PMC10903216 | DOI:10.1177/15330338241234798 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 29, 2024 Category: Cancer & Oncology Authors: Zhenghong Wu Jina Chen Lina Yang Ke Sun Qianqian Jiang Fuyun Dong Wei Lu Rujun Chen Yaping Chen Source Type: research

Elevated INHBA Promotes Tumor Progression of Cervical Cancer
Conclusion: In conclusion, our findings suggest that INHBA plays a crucial role in the progression of cervical cancer. The upregulation of INHBA is associated with poor patient survival, and its involvement in promoting key aspects of cancer progression makes it a potential therapeutic target for CCa treatment. These results provide valuable insights into the molecular mechanisms underlying CCa and offer a foundation for further exploration of targeted therapeutic interventions.PMID:38419562 | DOI:10.1177/15330338241234798 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 29, 2024 Category: Cancer & Oncology Authors: Zhenghong Wu Jina Chen Lina Yang Ke Sun Qianqian Jiang Fuyun Dong Wei Lu Rujun Chen Yaping Chen Source Type: research

Decanoylcarnitine Inhibits Triple-Negative Breast Cancer Progression via Mmp9 in an Intermittent Fasting Obesity Mouse
Conclusion: This study pioneers the exploration of IF intervention and the role of decanoylcarnitine/Mmp9 in the progression of TNBC in obese mice, enhancing our comprehension of the potential roles of various dietary patterns in the process of cancer treatment.PMID:38409962 | PMC:PMC10898300 | DOI:10.1177/15330338241233443 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 27, 2024 Category: Cancer & Oncology Authors: Yifan Tang Shuai Chen Saijun Wang Ke Xu Kun Zhang Dongmei Wang Ninghan Feng Source Type: research

Decanoylcarnitine Inhibits Triple-Negative Breast Cancer Progression via Mmp9 in an Intermittent Fasting Obesity Mouse
Conclusion: This study pioneers the exploration of IF intervention and the role of decanoylcarnitine/Mmp9 in the progression of TNBC in obese mice, enhancing our comprehension of the potential roles of various dietary patterns in the process of cancer treatment.PMID:38409962 | DOI:10.1177/15330338241233443 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 27, 2024 Category: Cancer & Oncology Authors: Yifan Tang Shuai Chen Saijun Wang Ke Xu Kun Zhang Dongmei Wang Ninghan Feng Source Type: research

The Value of Dual-Energy Computed Tomography-Based Radiomics in the Evaluation of Interstitial Fibers of Clear Cell Renal Carcinoma
CONCLUSION: DECT radiomics features have significant value in evaluating the interstitial fibers of ccRCC. The combined model of IMDI + MEI exhibits superior performance in assessing the thickness of the pseudocapsule, while the combined, 150 keV, and IMDI models demonstrate higher efficacy in evaluating collagen fiber number. Radiomics, combined with imaging features and clinical features, has excellent predictive performance. These findings offer crucial support for the clinical diagnosis, treatment, and prognosis of ccRCC and provide valuable insights into the application of DECT.PMID:38404055 | PMC:PMC10896050 | DOI:10...
Source: Technology in Cancer Research and Treatment - February 26, 2024 Category: Cancer & Oncology Authors: Xue Bing Ning Wang Yuhan Li Haitao Sun Jian Yao Ruobing Li Zhongyuan Li Aimei Ouyang Source Type: research

The Value of Dual-Energy Computed Tomography-Based Radiomics in the Evaluation of Interstitial Fibers of Clear Cell Renal Carcinoma
CONCLUSION: DECT radiomics features have significant value in evaluating the interstitial fibers of ccRCC. The combined model of IMDI + MEI exhibits superior performance in assessing the thickness of the pseudocapsule, while the combined, 150 keV, and IMDI models demonstrate higher efficacy in evaluating collagen fiber number. Radiomics, combined with imaging features and clinical features, has excellent predictive performance. These findings offer crucial support for the clinical diagnosis, treatment, and prognosis of ccRCC and provide valuable insights into the application of DECT.PMID:38404055 | DOI:10.1177/153303382412...
Source: Technology in Cancer Research and Treatment - February 26, 2024 Category: Cancer & Oncology Authors: Xue Bing Ning Wang Yuhan Li Haitao Sun Jian Yao Ruobing Li Zhongyuan Li Aimei Ouyang Source Type: research

Targeting Receptor Tyrosine Kinases as a Novel Strategy for the Treatment of Triple-Negative Breast Cancer
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241234780. doi: 10.1177/15330338241234780.ABSTRACTTriple-negative breast cancer (TNBC) comprises a group of aggressive and heterogeneous breast carcinoma. Chemotherapy is the mainstay for the treatment of triple-negative tumors. Nevertheless, the success of chemotherapeutic treatments is limited by their toxicity and development of acquired resistance leading to therapeutic failure and tumor relapse. Hence, there is an urgent need to explore novel targeted therapies for TNBC. Receptor tyrosine kinases (RTKs) are a family of transmembrane receptors that are key regulators of...
Source: Technology in Cancer Research and Treatment - February 23, 2024 Category: Cancer & Oncology Authors: Sara K Jaradat Nehad M Ayoub Ahmed H Al Sharie Julia M Aldaod Source Type: research

Proton Therapy in Breast Cancer: A Review of Potential Approaches for Patient Selection
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241234788. doi: 10.1177/15330338241234788.ABSTRACTProton radiotherapy may be a compelling technical option for the treatment of breast cancer due to its unique physical property known as the "Bragg peak." This feature offers distinct advantages, promising superior dose conformity within the tumor area and reduced radiation exposure to surrounding healthy tissues, enhancing the potential for better treatment outcomes. However, proton therapy is accompanied by inherent challenges, primarily higher costs and limited accessibility when compared to well-developed photon irradiat...
Source: Technology in Cancer Research and Treatment - February 23, 2024 Category: Cancer & Oncology Authors: Xiao-Yu Wu Mei Chen Lu Cao Min Li Jia-Yi Chen Source Type: research

Computer Vision and Machine-Learning Techniques for Automatic 3D Virtual Images Overlapping During Augmented Reality Guided Robotic Partial Nephrectomy
CONCLUSION: The first technology allowed a successful anchoring of the 3D model to the kidney, despite minimal manual refinements. The second technology improved kidney automatic detection without relying on indocyanine injection, resulting in better organ boundaries identification during tests. Further studies are needed to confirm this preliminary evidence.PMID:38374643 | PMC:PMC10878218 | DOI:10.1177/15330338241229368 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - February 20, 2024 Category: Cancer & Oncology Authors: Daniele Amparore Michele Sica Paolo Verri Federico Piramide Enrico Checcucci Sabrina De Cillis Alberto Piana Davide Campobasso Mariano Burgio Edoardo Cisero Giovanni Busacca Michele Di Dio Pietro Piazzolla Cristian Fiori Francesco Porpiglia Source Type: research