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Editorial Board
(Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - April 1, 2022 Category: Perinatology & Neonatology Source Type: research

Respiratory support of infants born at 22 –24 weeks of gestational age
Lung immaturity and acute respiratory failure are the major problems in the care of extremely preterm infants. Most infants with gestational age (GA) 22 –24 weeks will need mechanical ventilation and many will depend on some type of respiratory support, invasive and non-invasive for extended periods. There is ongoing gap in knowledge regarding optimal respiratory support and applying strategies that are effective in more mature populations is not easy or even suitable because lung maturation differs in smaller infants. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - April 1, 2022 Category: Perinatology & Neonatology Authors: Mikael Norman, Baldvin Jonsson, Linda Wallstr öm, Richard Sindelar Source Type: research

From immature pharmacotherapy towards pharmacotherapy of the immature
To truly attain effective and safe pharmacotherapy, the similarities and dissimilarities in physiology between micro-preemies and extreme preterm infants should be explored. The higher incidence of pulmonary hypertension and presence of adrenal insufficiency of prematurity in micro-preemies hereby serve as illustrations.The current limited data on pharmacokinetics, -dynamics and safety reflect the obvious need to collect such data, and to tailor modelling tools to their physiology and needs. Drug utilization hereby mirrors different needs and practices and may serve to guide prioritization decisions. (Source: Seminars in F...
Source: Seminars in Fetal and Neonatal Medicine - April 1, 2022 Category: Perinatology & Neonatology Authors: Karel Allegaert, John N. van den Anker Source Type: research

Respiratory support of infants born at 22-24 weeks of gestational age
Lung immaturity and acute respiratory failure are the major problems in the care of extremely preterm infants. Most infants with gestational age (GA) 22-24 weeks will need mechanical ventilation and many will depend on some type of respiratory support, invasive and non-invasive for extended periods. There is ongoing gap in knowledge regarding optimal respiratory support and applying strategies that are effective in more mature populations is not easy or even suitable because lung maturation differs in smaller infants. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - April 1, 2022 Category: Perinatology & Neonatology Authors: Mikael Norman, Baldvin Jonsson, Linda Wallstr öm, Richard Sindelar Source Type: research

Technology in the delivery room supporting the neonatal healthcare provider's task
Very preterm infants are a unique and highly vulnerable group of patients that have a narrow physiological margin within which interventions are safe and effective. The increased understanding of the foetal to neonatal transition marks the intricacy of the rapid and major physiological changes that take place, making delivery room stabilisation and resuscitation an increasingly complex and sophisticated activity for caregivers to perform. While modern, automated technologies are progressively implemented in the neonatal intensive care unit (NICU) to enhance the caregivers in providing the right care for these patients, the...
Source: Seminars in Fetal and Neonatal Medicine - March 31, 2022 Category: Perinatology & Neonatology Authors: Sophie J.E. Cramer, Kristel L.A.M. Kuypers, Tessa Martherus, Janneke Dekker, Arjan B. te Pas Source Type: research

Technology in the delivery room supporting the neonatal healthcare provider ’s task
Very preterm infants are a unique and highly vulnerable group of patients that have a narrow physiological margin within which interventions are safe and effective. The increased understanding of the foetal to neonatal transition marks the intricacy of the rapid and major physiological changes that take place, making delivery room stabilisation and resuscitation an increasingly complex and sophisticated activity for caregivers to perform. While modern, automated technologies are progressively implemented in the neonatal intensive care unit (NICU) to enhance the caregivers in providing the right care for these patients, the...
Source: Seminars in Fetal and Neonatal Medicine - March 31, 2022 Category: Perinatology & Neonatology Authors: Sophie J.E. Cramer, Kristel L.A.M. Kuypers, Tessa Martherus, Janneke Dekker, Arjan B. te Pas Source Type: research

Hemodynamic Management of the Micropreemie: When Inotropes are Not Enough
Managing perfusion in the micropreemie is challenging and should be guided by the patho-physiology, gestational and postnatal age of the baby, perinatal history, and the persistence of fetal shunts. The assessment should incorporate bedside tools such as blood pressure, clinical perfusion markers, and functional echocardiography. The multimodal approach to diagnose and identify the cause of hemodynamic compromise paves the way to a targeted approach to treatment. Characterizing the predominant pathophysiologic cause of low cardiac output and impaired cellular metabolism enables a more accurate use of inotropes, vasopressor...
Source: Seminars in Fetal and Neonatal Medicine - March 31, 2022 Category: Perinatology & Neonatology Authors: Samir Gupta, Steven M. Donn Source Type: research

Clinical Decision Support in the Neonatal ICU
This article also serves as a primer on what to think about when proposing the development of a new CDS tool, or when upgrading an existing one. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - March 31, 2022 Category: Perinatology & Neonatology Authors: Anoop Rao, Jonathan Palma Source Type: research

Stem Cells in Neonatal Diseases: An Overview
Preterm birth and its common complications are major causes of infant mortality and long-term morbidity. Despite great advances in understanding the pathogenesis of neonatal diseases and improvements in neonatal intensive care, effective therapies for the prevention or treatment for these conditions are still lacking. Stem cell (SC) therapy is rapidly emerging as a novel therapeutic tool for several diseases of the newborn with encouraging pre-clinical results that hold promise for translation to the bedside. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - March 28, 2022 Category: Perinatology & Neonatology Authors: Sushma Chaubey, Vineet Bhandari Source Type: research

Introduction
As the Guest Editor for the Regenerative Medicine issue for the Seminars in Fetal Neonatal Medicine, I have tried to encompass the latest concepts and progress in this area as it pertains to fetal and neonatal medicine. Towards that goal, I invited leading researchers from around the world to provide the most up-to-date information in their area of expertise. This project was impacted by the Covid-19 pandemic and took 2 years to come to fruition. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - March 25, 2022 Category: Perinatology & Neonatology Authors: Vineet Bhandari Source Type: research

Persistent Pulmonary Hypertension of the Newborn: Historical Perspectives
For many decades, persistent pulmonary hypertension of the newborn (PPHN) remained a baffling disorder, often confused with cyanotic congenital heart disease, with a very high mortality. Originally described as a condition characterized by clear lung fields and profound hypoxemia, modern diagnostic techniques and novel therapeutics have improved the outcomes of affected newborns. This paper will review the historical aspects of PPHN and enable the reader to see how far we have come but also how far we have to go in conquering this unique disorder. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - February 13, 2022 Category: Perinatology & Neonatology Authors: Steven M. Donn Source Type: research

Editorial Board
(Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - February 1, 2022 Category: Perinatology & Neonatology Source Type: research

Placental Tissue Stem Cells and their role in Neonatal Diseases
Neonatal diseases such as hypoxic ischemic encephalopathy, diseases of prematurity and congenital disorders carry increased morbidity and mortality. Despite technological advancements, their incidence remains largely unabated. Stem cell (SC) interventions are novel therapies in the neonatal world. In pre-clinical models of neonatal diseases, SC applications have shown encouraging results. SC sources vary, with the bone marrow being the most utilized. However, the ability to harvest bone marrow SCs from neonates is limited. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - December 20, 2021 Category: Perinatology & Neonatology Authors: Andreas Damianos, Kui Xu, Gregory T. Kalin, Vladimir V. Kalinichenko Source Type: research

Editorial Board
(Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - November 23, 2021 Category: Perinatology & Neonatology Source Type: research

Neuroimaging in the term newborn with neonatal encephalopathy
Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive bioma...
Source: Seminars in Fetal and Neonatal Medicine - October 26, 2021 Category: Perinatology & Neonatology Authors: Jessica L. Wisnowski, Pia Wintermark, Sonia L. Bonifacio, Christopher D. Smyser, A. James Barkovich, A. David Edwards, Linda S. de Vries, Terrie E. Inder, Vann Chau, Newborn Brain Society Guidelines and Publications Committee Source Type: research