Use of primary health care and radiological imaging preceding a diagnosis of rheumatoid arthritis: a nationwide cohort study in Denmark
ConclusionIncreased contacts to general practitioners and physiotherapists were seen in all 12 months preceding the RA diagnosis, intensifying in the last 6 to 8 months. Imaging increased from 3 months before the diagnosis. This indicates an opportunity to expedite referral to specialist care and ensure earlier diagnosis of RA. (Source: Rheumatology)
Source: Rheumatology - June 17, 2022 Category: Rheumatology Source Type: research
TOX promotes follicular helper T cell differentiation in patients with primary Sj ögren’s syndrome
ConclusionOur data suggest thatTOX in pSS naive CD4+ T cells is upregulated, which facilitates Tfh cell differentiation. Mechanistically, IFN- α inducesTOX overexpression in naive CD4+ T cells through JAK –STAT1 signalling and TOX regulatesBCL6 expression. Therefore, IFN- α-JAK–STAT1 signalling andTOX might be potential therapeutic targets in pSS. (Source: Rheumatology)
Source: Rheumatology - June 17, 2022 Category: Rheumatology Source Type: research
The role of YAP1 target gene CTGF in the anoikis resistance of rheumatoid arthritis synovial fibroblasts
ConclusionThe elucidation of a new molecular mechanism that protects RASFs in the highly pro-apoptotic environment of inflamed RA joints by promoting anoikis-resistance and transendothelial migration via ADAM15/YAP1-mediated CTGF upregulation uncovers potentially new targets for future therapeutic intervention. (Source: Rheumatology)
Source: Rheumatology - June 17, 2022 Category: Rheumatology Source Type: research
Lung vascular changes as biomarkers of severity in systemic sclerosis –associated interstitial lung disease
ConclusionIn SSc patients CT vessel parameters increase in parallel with ILD extent and functional impairment, and may represent a biomarker of SSc-ILD severity. (Source: Rheumatology)
Source: Rheumatology - June 16, 2022 Category: Rheumatology Source Type: research
Circulating and renal fibrocytes are associated with interstitial fibrosis in lupus nephritis
ConclusionFibrocytes were significantly increased in the blood and kidney tissue of patients with LN, especially those with interstitial fibrosis. Fibrocytes could be differentiated from blood cells, with an active contribution from RTECs. Our results show a possible link between fibrocytes and tubulointerstitial fibrosis, which may serve as a novel therapeutic target for LN fibrogenesis. (Source: Rheumatology)
Source: Rheumatology - June 15, 2022 Category: Rheumatology Source Type: research
Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry
ConclusionsFive trajectories of JIA disease activity, and associated baseline variables, were identified. (Source: Rheumatology)
Source: Rheumatology - June 15, 2022 Category: Rheumatology Source Type: research
Interstitial lung disease in ANCA-associated vasculitis: associated factors, radiographic features and mortality
ConclusionILD is a frequent complication of AAV, especially MPO-ANCA+ AAV, often preceding recognition of AAV. Fibrotic AAV-ILD is associated with a higher risk of death than AAV without ILD. (Source: Rheumatology)
Source: Rheumatology - June 14, 2022 Category: Rheumatology Source Type: research
Resting state functional connectivity in SLE patients and association with cognitive impairment and blood –brain barrier permeability
ConclusionSLE patients with cognitive impairment had abnormalities in brain rsFC which accounted for most of the association between extensive BBB leakage and cognitive impairment. (Source: Rheumatology)
Source: Rheumatology - June 14, 2022 Category: Rheumatology Source Type: research
Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography
ConclusionMSOT allows determination of distinct metabolic differences between arthritis and enthesitis in a non-invasive setting in humansin vivo. (Source: Rheumatology)
Source: Rheumatology - June 14, 2022 Category: Rheumatology Source Type: research
Comment on: Distal coronary artery abnormalities in Kawasaki disease: experience on CT coronary angiography in 176 children
Dear Editor, We read with interest the recent article by Singhalet al. [1] outlining a novel approach to the assessment of coronary artery abnormalities (CAAs) in Kawasaki disease using CT coronary angiography (CTCA) for evaluation in distal segments. (Source: Rheumatology)
Source: Rheumatology - June 14, 2022 Category: Rheumatology Source Type: research
Comment on: Distal coronary artery abnormalities in Kawasaki disease: experience on CT coronary angiography in 176 children: reply
Dear Editor, We thank Maccoraet al. [1] for their interest in our manuscript [2] on distal coronary artery abnormalities (CAAs) in children with Kawasaki disease (KD) using radiation-optimized CT coronary angiography (CTCA). (Source: Rheumatology)
Source: Rheumatology - June 14, 2022 Category: Rheumatology Source Type: research
L-shaped association between serum 25-hydroxyvitamin D and all-cause mortality of individuals with rheumatoid arthritis
ConclusionAn L-shaped association between serum 25-hydroxyvitamin D and all-cause mortality was found among patients with RA, indicating that serum 25-hydroxyvitamin D should be improved to a certain level for the prevention of premature death. (Source: Rheumatology)
Source: Rheumatology - June 11, 2022 Category: Rheumatology Source Type: research
Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis
ConclusionsPlasma His levels are a potential biomarker for SLE patients and are associated with damage accrual. Our data suggest the importance of His as a pathogenic metabolite in SLE pathogenesis. (Source: Rheumatology)
Source: Rheumatology - June 11, 2022 Category: Rheumatology Source Type: research
Subclinical atherosclerosis profiles in rheumatoid arthritis and primary Sj ögren’s syndrome: the impact of BAFF genetic variations
ConclusionsIncreased inflammatory burden, higher steroid doses and distinct BAFF gene variations imply chronic inflammation and B-cell hyperactivity as key contributors for the augmented atherosclerotic risk among autoimmune patients. (Source: Rheumatology)
Source: Rheumatology - June 11, 2022 Category: Rheumatology Source Type: research
Trajectories of depressive symptoms in systemic lupus erythematosus over time
ConclusionFour classes of depressive symptoms were identified in patients with SLE. Understanding the trajectories of depressive symptoms and the associated risk factors can aid in the management of these symptoms in individuals living with SLE. (Source: Rheumatology)
Source: Rheumatology - June 10, 2022 Category: Rheumatology Source Type: research
