P149 The intracellular chloride channel 4 (CLIC4) plays an important role in systemic sclerosis fibroblast activation
Conclusion We have identified a novel role for CLIC4 in SSc myofibroblast activation, which further strengthen the similarities between SSc fibroblasts and cancer associated fibroblasts. Furthermore this study highlights this channel as a novel target for therapeutic intervention.Disclosure C. Wasson: None.R. Ross: None.R. Morton: None.J. Mankouri: None.F. Del Galdo: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P148 Differential methylation of the TNF gene promoter, potential for the development of a diagnostic biomarker for RA
Conclusion The loss of DNA methylation on the TNF gene promoter identified in early RA patients provided a valuable target for a biomarker assay development. The results will need to be confirmed in a larger cohort but the TNF-qMSP assay offers good opportunities for RA versus non-RA classification particul ar in antibody negative disease.Disclosure R. Pitaksalee: Grants/research support; ROYAL THAI GOVERNMENT SCHOLARSHIP.P. Emery: None.R. Hodgett: None.F. Ponchel: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P147 Safety of AbatacePt in Rheumatoid arthritis associated Interstitial Lung disease (APRIL)
Conclusion Our data indicates that abatacept has an acceptable safety profile in progressive pulmonary fibrosis associated with RA-ILD. This small dataset also suggests that ILD has not progressed during the period of treatment. P147 Table 1:Summary of outcomes after 20 weeks’ treatment with Abatacept i n RA patients with progressive interstitial lung diseaseN = 10Baseline20 WeekFVC (L)2.78 ± 0.903.0 ± 0.89TLCOc (mmol/min/kPa)3.75 ± 1.033.72 ± 1.00K-BILD49.10 ± 5.5054.40 ± 6.0LCQ4.78 ± 1.514.82 ± 1.32Disclosure T. Gudu: None.C. Stober: None.M. Fifield: None.J. Babar: None.A. Ostor: None.H. Parfrey: None.F. ...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P146 Investigating the role of T regulatory cells in the amelioration of RA in pregnancy
Conclusion We found a significant increase in activation of Tregs measured by CD69 in T3 of both pregnancy groups, implying that the pregnant state enhances the function of these cells and may thus lead to amelioration of RA. Although disease activity measured by DAS28(3)CRP and MSK-US was not correlated wi th Treg activation in T3, the strong negative correlation of these scores with %FOXP3+ Tregs in PP may link a decline in their suppressive function with PP flare. Further work is underway to clarify these findings.Disclosure C. Raine: Grants/research support; CR has received funding for research from UCB.G. Robinson...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P145 Computational analysis of neutrophil gene expression reveals activation signatures associated with DMARD refractory rheumatoid arthritis
Conclusion The results of the computational analyses are currently being validated experimentally.Disclosure M. Fresneda Alarcon: None.E. Caamano-Gutierrez: None.P. Antczak: None.R.J. Moots: None.H.L. Wright: Grants/research support; H.W. has received funding from Versus Arthritis and the Masonic Charitable Fund. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P144 What is the role of musculoskeletal ultrasound in assessing disease activity of RA in pregnancy?
Conclusion Interestingly, we found that that DAS28(3)CRP correlates better with PD signal on MSK-US in pregnancy than in non-pregnancy. Specifically, there was significantly better correlation of the TJC with PD score. It is unclear why non-inflammatory contributors to the TJC may be less prominent in pregn ancy and further investigation is warranted.Disclosure C. Raine: Grants/research support; C.R. has received research funding from UCB.J. Manson: None.C. Ciurtin: None.I. Giles: Grants/research support; IG has received an unrestricted educational grant, speaker's fees and travel fees from UCB. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P143 The effect of JAK inhibition on the metabolome of neutrophils from patients with rheumatoid arthritis
Conclusion The metabolome of RA and HC neutrophils is different at baseline. JAKi alter the levels of intracellular metabolites involved in neutrophil activation and ROS production in RA. This may explain, in part, the efficacy of JAKi in decreasing disease activity and joint damage in RA.Disclosure M. Fresneda Alarcon: None.R. Grosman: None.S. Chokesuwattanaskul: None.M. Phelan: None.H. Wright: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P112 Teriparatide versus anti-resorptive treatment in rheumatoid arthritis patients with severe osteoporosis: an observational study
Conclusion This real-world study confirms that TPTD treatment is more effective in treating severe spinal OP in RA patients than antiresorptive medication alone. Despite the fact that the majority of RA patients had been pre-treated with bisphosphonates the TPTD treatment effect in RA patients was robust. A nabolic treatment with TPTD is a good option for RA patients with severe spinal OP.Disclosure B. Hauser: Other; Dr Hauser has received fees for a promotional article from Gedeon Richter.K.M. Berg: None.J.A. Lambert: None.S.H. Ralston: Grants/research support; Prof Ralston has received grant funding from Lilly for an...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P111 Osteoporosis is a significant predictor of frailty in older community dwelling adults: findings from the Hertfordshire Cohort Study
Conclusion Our findings demonstrate that the presence of OP is a significant predictive factor for developing frailty and might be used as a trigger for appropriate interventions to reduce or reverse its development in older adults. Our findings are in accordance with the previous reports in Asian populatio ns and warrant further investigation in other national cohorts.Disclosure F. Laskou: None.K. Jameson: None.E. Dennison: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P110 Sex differences in hand osteoarthritis symptoms and function
Conclusion The results demonstrate the presence of sex differences in patients suffering from hand osteoarthritis self-reported functional ability and pain scales. These differences indicate the need for further studies to explore the mechanisms of hand OA and to understanding the specific impact of gender on the development and progression of disease. With further understanding we can obtain the proper strategy to provide better individualised treatment. It also highlights that rehabilitation programs should consider these differences and each patients’ performance limitations in order to address t he specific needs o...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P108 Anti-nerve growth factor (anti-NGF) antibodies as analgesia in the management of osteoarthritis
Conclusion Anti-NGF antibodies appear very promising with regard to alleviating osteoarthritic hip/knee pain but more studies are needed to determine the optimal dosage and the overall risk-to benefit ratio, particularly with long-term use.Disclosure J. Rammanohar: None.J. Sutton: None.K. Seah: None.W.S. Khan: None.K. To: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P107 Can a computer sense the symptoms of osteoarthritis from a radiograph? Initial findings from a pilot, AI approach to osteoarthritis assessment
Conclusion To conclude, in this pilot study, we have trained an algorithm, to diagnose osteoarthritis of the knees and hips with limited accuracy. We have also demonstrated moderate correlations with some specific pain symptoms. It will be interesting to see whether these initial findings are replicated as we expand this project into other cohorts.Disclosure N.R. Fuggle: None.D. Pinto Pereira: None.E.M. Dennison: None.C. Cooper: None.S. Mahmoodi: None. (Source: Rheumatology)
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P106 Planning and development of a long-term digital self-management tool for osteoarthritis: the Intelligent Knee Osteoarthritis Lifestyle App
Conclusion The Intelligent Knee Osteoarthritis Lifestyle App (iKOALA) is an evidence-based smartphone app to support long-term self-management for individuals with KOA. The app facilitates appropriate physical activity adoption and maintenance; provides feedback from linked wearable activity trackers; gives information and intelligently tailored physical activity options from patient preferences and symptoms. Broader self-management aspects include rehabilitation exercise content, symptom tracking and alerts, weight management tools and education resources. Crucially, for long-term maintenance, the ap p includes forum fe...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P105 Auto-inflammatory idiopathic serositis: an under-characterised phenomenon?
Conclusion Auto-inflammatory idiopathic serositis appears to be distinct category of serositis affecting predominantly middle aged to elderly female Caucasian patients, without underlying connective tissue disease, requiring prolonged therapy with immunosuppressive agents, which can be characterised by invo lvement of multiple serous membranes and/or recurrent episodes of serositis. This condition appears to respond well to immune suppression with steroids, steroid-sparing agents and Anakinra. Further work will be required to characterise and classify this condition and to establish treatment guideline s.Disclosure K. ...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
P104 A review of patients referred to Rheumatology with haemophagocytic lymphohistiocytosis who were treated with anakinra successfully
Conclusion We present data from nine cases of HLH treated with anakinra who survived their admission and have been subsequently followed up in clinic. We found that the majority of these patients had an underlying diagnosis of adult onset Still’s disease. Anakinra was used successfully as part of their tr eatment both intravenously as well as subcutaneously. Further work is needed comparing patients with good and poor outcomes to establish identifiable prognostic markers as well as effective treatment strategies.Disclosure D. Kurzeja: None.J. Perera: None.K. Pillai: None.S. Amin: None.R. Stratton: None.A. Singh: None...
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
