TOX promotes follicular helper T cell differentiation in patients with primary Sj ögren’s syndrome

ConclusionOur data suggest thatTOX in pSS naive CD4+ T cells is upregulated, which facilitates Tfh cell differentiation. Mechanistically, IFN- α inducesTOX overexpression in naive CD4+ T cells through JAK –STAT1 signalling and TOX regulatesBCL6 expression. Therefore, IFN- α-JAK–STAT1 signalling andTOX might be potential therapeutic targets in pSS.
Source: Rheumatology - Category: Rheumatology Source Type: research