Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus –associated refractory cerebral vasculitis induces immune tolerance
Rheumatology key message • This case underscores the fundamental considerations of targeting plasma cells in autoimmune diseases such as SLE. (Source: Rheumatology)
Source: Rheumatology - July 8, 2022 Category: Rheumatology Source Type: research
IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via I κBζ-dependent induction of ELF3
ConclusionAltogether, our results establish ELF3 as an important mediator of the synergistic effect of IL-17A and TNF in synovial fibroblasts. The findings provide novel information of the pathogenic mechanisms of IL-17A in chronic arthritis and implicate ELF3 as a potential therapeutic target. (Source: Rheumatology)
Source: Rheumatology - July 6, 2022 Category: Rheumatology Source Type: research
Rheumatology research in the post-COVID era —challenges and solutions
The coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought to light issues that require careful appraisal of several scientific domains, including research. While the current pandemic appears to be subsiding, the threat of future waves driven by variants of SARS-CoV-2 and of similar pandemics in the future cannot be ignored. In this editorial, we reflect upon some specific considerations for rheumatology research in the post-COVID era. (Source: Rheumatology)
Source: Rheumatology - July 6, 2022 Category: Rheumatology Source Type: research
Long-term cardiovascular outcomes and temporal trends in patients diagnosed with ANCA-associated vasculitis: a Danish nationwide registry study
ConclusionsPatients with AAV are at increased risk of heart failure, atrial-/ventricular arrhythmias, venous thrombotic events, ischaemic stroke and myocardial infarction. Furthermore, patients with AAV were more frequently examined with coronary procedures and underwent more coronary revascularizations. No temporal changes in ischaemic cardiovascular outcomes were observed, albeit the cardiovascular mortality has decreased over time. (Source: Rheumatology)
Source: Rheumatology - July 5, 2022 Category: Rheumatology Source Type: research
Effect of bimekizumab on symptoms and impact of disease in patients with psoriatic arthritis over 3 years: results from BE ACTIVE
ConclusionsBimekizumab treatment was associated with long-term sustained improvements in pain and fatigue, reducing overall impact of PsA on patients. Physical function and quality of life improved up to 3 years.Trial registrationClinicalTrials.gov,https://clinicaltrials.gov, NCT02969525, NCT03347110. (Source: Rheumatology)
Source: Rheumatology - July 5, 2022 Category: Rheumatology Source Type: research
Inhibition of calcium/calmodulin-dependent protein kinase IV in arthritis: dual effect on Th17 cell activation and osteoclastogenesis
ConclusionUsing global and CD4-cell-targeted pharmacologic approaches and conditionally deficient mice, we demonstrate that CaMK4 is important in the development of arthritis. Usingex vivo cell cultures from patients with RA, CaMK4 is important for both Th17 generation and osteoclastogenesis. We propose that CaMK4 inhibition represents a new approach to control the development of arthritis. (Source: Rheumatology)
Source: Rheumatology - July 4, 2022 Category: Rheumatology Source Type: research
Anti-CD74 IgA antibodies show diagnostic potential for axial spondyloarthritis but are not associated with microscopic gut inflammation
ConclusionSerum anti-CD74 IgA is a potentially useful diagnostic biomarker for axSpA. However, antibody levels do not correlate with any phenotypical feature, including microscopic gut inflammation, suggesting this to be a disease-specific rather than an inflammatory marker. (Source: Rheumatology)
Source: Rheumatology - July 4, 2022 Category: Rheumatology Source Type: research
Peripheral expansion of myeloid-derived suppressor cells is related to disease activity and damage accrual in inflammatory myopathies
ConclusionMDSCs expressing arginase-1 and PD-L1 are expanded in IIM and correlate with disease activity, damage accrual and serum cytokines. (Source: Rheumatology)
Source: Rheumatology - June 29, 2022 Category: Rheumatology Source Type: research
Guselkumab provides sustained domain-specific and comprehensive efficacy using composite indices in patients with active psoriatic arthritis
ConclusionTreatment with guselkumab provided robust and sustained benefits across multiple PsA domains through 1 year, indicating that guselkumab is an effective therapy for the diverse manifestations of PsA.Trial registrationNCT03162796; NCT03158285 (Source: Rheumatology)
Source: Rheumatology - June 29, 2022 Category: Rheumatology Source Type: research
Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses
ConclusionThe variants in geneSLC2A9 are the major genetic factors for females associated with gout in those aged ≥50. PRS can provide a more robust prediction of the gout/AH under a homogeneous selection of variants that show effects on the traits. (Source: Rheumatology)
Source: Rheumatology - June 27, 2022 Category: Rheumatology Source Type: research
Immunosuppressive treatments selectively affect the humoral and cellular response to SARS-CoV-2 in vaccinated patients with vasculitis
ConclusionsAlthough patients with GCA apparently achieve a robust antibody seroconversion, there is a significant impairment of the neutralizing activity. MTX significantly reduced all levels of the humoral response. Up to one-third of patients do not develop a cellular immune protection in response to COVID-19 vaccination. (Source: Rheumatology)
Source: Rheumatology - June 23, 2022 Category: Rheumatology Source Type: research
Upregulated expression of FFAR2 and SOC3 genes is associated with gout
ConclusionFFAR2 upregulation is associated with gout and may trigger gout flares.SOCS3 may have a role in amelioration of gout flares. (Source: Rheumatology)
Source: Rheumatology - June 22, 2022 Category: Rheumatology Source Type: research
Female reproductive status and exogenous sex hormone use in rheumatoid arthritis patients treated with tocilizumab and csDMARDs
ConclusionPerimenopausal women were less likely to achieve remission compared with premenopausal RA patients. The use of exogenous sex hormones appeared to be associated with more frequent remission in female RA patients, particularly those who were perimenopausal and early postmenopausal, although further research is required to confirm and identify the drivers for this observation and how it interacts with menopausal status. (Source: Rheumatology)
Source: Rheumatology - June 22, 2022 Category: Rheumatology Source Type: research
Accuracy of power Doppler ultrasonography in the diagnosis and monitoring of idiopathic inflammatory myopathies
ConclusionOur findings show that PDUS is a reliable diagnostic tool in the differential diagnosis between inflammatory and non-inflammatory myopathies. Moreover, PDUS can be employed also during the follow-up of patients with IIM. A reduction in disease activity, measured by physician global assessment, led to a concomitant decrease in both oedema and PD, which was directly correlated with their rate of change. This underlines the close link between clinical assessment and PDUS findings, not only at diagnosis but also during monitoring. (Source: Rheumatology)
Source: Rheumatology - June 22, 2022 Category: Rheumatology Source Type: research
Is the risk of infection higher during treatment with secukinumab than with TNF inhibitors? An observational study from the Nordic countries
ConclusionWhen used according to clinical practice in the Nordic countries, the observed first-year absolute risk of hospitalized infection was doubled for secukinumab compared with adalimumab. This excess risk seemed largely explained by confounding by indication. (Source: Rheumatology)
Source: Rheumatology - June 20, 2022 Category: Rheumatology Source Type: research
