The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
Radiat Environ Biophys. 2023 Jun 19. doi: 10.1007/s00411-023-01033-4. Online ahead of print.ABSTRACTCandidate ionising radiation exposure biomarkers must be validated in humans exposed in vivo. Blood from patients undergoing positron emission tomography-computed tomography scan (PET-CT) and skeletal scintigraphy (scintigraphy) was drawn before (0 h) and after (2 h) the procedure for correlation analyses of the response of selected biomarkers with radiation dose and other available patient information. FDXR, CDKN1A, BBC3, GADD45A, XPC, and MDM2 expression was determined by qRT-PCR, DNA damage (γH2AX) by flow cytometry, and...
Source: Radiation and Environmental Biophysics - June 19, 2023 Category: Physics Authors: Milagrosa L ópez-Riego Magdalena P łódowska Milena Lis-Zaj ęcka Kamila Jeziorska Sylwia Tetela Aneta W ęgierek-Ciuk Daniel Sobota Janusz Braziewicz Lovisa Lundholm Halina Lisowska Andrzej Wojcik Source Type: research

The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
Radiat Environ Biophys. 2023 Jun 19. doi: 10.1007/s00411-023-01033-4. Online ahead of print.ABSTRACTCandidate ionising radiation exposure biomarkers must be validated in humans exposed in vivo. Blood from patients undergoing positron emission tomography-computed tomography scan (PET-CT) and skeletal scintigraphy (scintigraphy) was drawn before (0 h) and after (2 h) the procedure for correlation analyses of the response of selected biomarkers with radiation dose and other available patient information. FDXR, CDKN1A, BBC3, GADD45A, XPC, and MDM2 expression was determined by qRT-PCR, DNA damage (γH2AX) by flow cytometry, and...
Source: Radiation and Environmental Biophysics - June 19, 2023 Category: Physics Authors: Milagrosa L ópez-Riego Magdalena P łódowska Milena Lis-Zaj ęcka Kamila Jeziorska Sylwia Tetela Aneta W ęgierek-Ciuk Daniel Sobota Janusz Braziewicz Lovisa Lundholm Halina Lisowska Andrzej Wojcik Source Type: research

Fetal atomic bomb survivor dosimetry using the J45 series of pregnant female phantoms with realistic survivor exposure scenarios: comparisons to dose estimates in the DS02 system
Radiat Environ Biophys. 2023 Jun 9. doi: 10.1007/s00411-023-01032-5. Online ahead of print.ABSTRACTA significant source of information on radiation-induced biological effects following in-utero irradiation stems from studies of atomic bomb survivors who were pregnant at the time of exposure in Hiroshima, and to a lesser extent, from survivors in Nagasaki. Dose estimates to the developing fetus for these survivors have been assigned in prior dosimetry systems of the Radiation Effects Research Foundation as the dose to the uterine wall within the non-pregnant adult stylized phantom, originally designed for the dosimetry syst...
Source: Radiation and Environmental Biophysics - June 9, 2023 Category: Physics Authors: Colin J Paulbeck Tatsuhiko Sato Sachiyo Funamoto Choonsik Lee Keith T Griffin Harry M Cullings Stephen D Egbert Akira Endo Nolan E Hertel Wesley E Bolch Source Type: research

Fetal atomic bomb survivor dosimetry using the J45 series of pregnant female phantoms with realistic survivor exposure scenarios: comparisons to dose estimates in the DS02 system
Radiat Environ Biophys. 2023 Jun 9. doi: 10.1007/s00411-023-01032-5. Online ahead of print.ABSTRACTA significant source of information on radiation-induced biological effects following in-utero irradiation stems from studies of atomic bomb survivors who were pregnant at the time of exposure in Hiroshima, and to a lesser extent, from survivors in Nagasaki. Dose estimates to the developing fetus for these survivors have been assigned in prior dosimetry systems of the Radiation Effects Research Foundation as the dose to the uterine wall within the non-pregnant adult stylized phantom, originally designed for the dosimetry syst...
Source: Radiation and Environmental Biophysics - June 9, 2023 Category: Physics Authors: Colin J Paulbeck Tatsuhiko Sato Sachiyo Funamoto Choonsik Lee Keith T Griffin Harry M Cullings Stephen D Egbert Akira Endo Nolan E Hertel Wesley E Bolch Source Type: research

Fetal atomic bomb survivor dosimetry using the J45 series of pregnant female phantoms with realistic survivor exposure scenarios: comparisons to dose estimates in the DS02 system
Radiat Environ Biophys. 2023 Jun 9. doi: 10.1007/s00411-023-01032-5. Online ahead of print.ABSTRACTA significant source of information on radiation-induced biological effects following in-utero irradiation stems from studies of atomic bomb survivors who were pregnant at the time of exposure in Hiroshima, and to a lesser extent, from survivors in Nagasaki. Dose estimates to the developing fetus for these survivors have been assigned in prior dosimetry systems of the Radiation Effects Research Foundation as the dose to the uterine wall within the non-pregnant adult stylized phantom, originally designed for the dosimetry syst...
Source: Radiation and Environmental Biophysics - June 9, 2023 Category: Physics Authors: Colin J Paulbeck Tatsuhiko Sato Sachiyo Funamoto Choonsik Lee Keith T Griffin Harry M Cullings Stephen D Egbert Akira Endo Nolan E Hertel Wesley E Bolch Source Type: research