Vibrational spectroscopies for biochemical investigation of X-ray exposure effects on SH-SY5Y human neuroblastoma cells
Radiat Environ Biophys. 2023 Jul 1. doi: 10.1007/s00411-023-01035-2. Online ahead of print.ABSTRACTNeuroblastoma is the most recurring cancer in childhood and adolescence. The SH-SY5Y neuroblastoma cell line is generally adopted for elaborating new therapeutical approaches and/or elaborating strategies for the prevention of central nervous system disturbances. In fact, it represents a valid model system for investigating in vitro the effects on the brain of X-ray exposure using vibrational spectroscopies that can detect early radiation-induced molecular alterations of potential clinical usefulness. In recent years, we dedi...
Source: Radiation and Environmental Biophysics - July 1, 2023 Category: Physics Authors: Valerio Ricciardi Maria Lasalvia Giuseppe Perna Marianna Portaccio Ines Delfino Maria Lepore Vito Capozzi Lorenzo Manti Source Type: research

Vibrational spectroscopies for biochemical investigation of X-ray exposure effects on SH-SY5Y human neuroblastoma cells
Radiat Environ Biophys. 2023 Jul 1. doi: 10.1007/s00411-023-01035-2. Online ahead of print.ABSTRACTNeuroblastoma is the most recurring cancer in childhood and adolescence. The SH-SY5Y neuroblastoma cell line is generally adopted for elaborating new therapeutical approaches and/or elaborating strategies for the prevention of central nervous system disturbances. In fact, it represents a valid model system for investigating in vitro the effects on the brain of X-ray exposure using vibrational spectroscopies that can detect early radiation-induced molecular alterations of potential clinical usefulness. In recent years, we dedi...
Source: Radiation and Environmental Biophysics - July 1, 2023 Category: Physics Authors: Valerio Ricciardi Maria Lasalvia Giuseppe Perna Marianna Portaccio Ines Delfino Maria Lepore Vito Capozzi Lorenzo Manti Source Type: research

Distributions of energy imparted to a micro-volume by secondary charged fragments of nuclear interactions in space radiation field
Radiat Environ Biophys. 2023 Jun 24. doi: 10.1007/s00411-023-01034-3. Online ahead of print.ABSTRACTThe field of cosmic radiation at low-Earth orbit (LEO) has a complex composition. It always contains a component of secondary charged particles, formed by the products of nuclear interactions of the primary high-energy radiation with the nuclei of spacecraft's shielding material, electronic components and biological matter on board. Generation of this secondary radiation can be observed in some track detectors in the form of "stars" formed by tracks-fragments with a common vertex. The energy absorbed by the medium in the reg...
Source: Radiation and Environmental Biophysics - June 24, 2023 Category: Physics Authors: S N Fedotov V V Kushin Source Type: research

Distributions of energy imparted to a micro-volume by secondary charged fragments of nuclear interactions in space radiation field
Radiat Environ Biophys. 2023 Jun 24. doi: 10.1007/s00411-023-01034-3. Online ahead of print.ABSTRACTThe field of cosmic radiation at low-Earth orbit (LEO) has a complex composition. It always contains a component of secondary charged particles, formed by the products of nuclear interactions of the primary high-energy radiation with the nuclei of spacecraft's shielding material, electronic components and biological matter on board. Generation of this secondary radiation can be observed in some track detectors in the form of "stars" formed by tracks-fragments with a common vertex. The energy absorbed by the medium in the reg...
Source: Radiation and Environmental Biophysics - June 24, 2023 Category: Physics Authors: S N Fedotov V V Kushin Source Type: research

Distributions of energy imparted to a micro-volume by secondary charged fragments of nuclear interactions in space radiation field
Radiat Environ Biophys. 2023 Jun 24. doi: 10.1007/s00411-023-01034-3. Online ahead of print.ABSTRACTThe field of cosmic radiation at low-Earth orbit (LEO) has a complex composition. It always contains a component of secondary charged particles, formed by the products of nuclear interactions of the primary high-energy radiation with the nuclei of spacecraft's shielding material, electronic components and biological matter on board. Generation of this secondary radiation can be observed in some track detectors in the form of "stars" formed by tracks-fragments with a common vertex. The energy absorbed by the medium in the reg...
Source: Radiation and Environmental Biophysics - June 24, 2023 Category: Physics Authors: S N Fedotov V V Kushin Source Type: research

Distributions of energy imparted to a micro-volume by secondary charged fragments of nuclear interactions in space radiation field
Radiat Environ Biophys. 2023 Jun 24. doi: 10.1007/s00411-023-01034-3. Online ahead of print.ABSTRACTThe field of cosmic radiation at low-Earth orbit (LEO) has a complex composition. It always contains a component of secondary charged particles, formed by the products of nuclear interactions of the primary high-energy radiation with the nuclei of spacecraft's shielding material, electronic components and biological matter on board. Generation of this secondary radiation can be observed in some track detectors in the form of "stars" formed by tracks-fragments with a common vertex. The energy absorbed by the medium in the reg...
Source: Radiation and Environmental Biophysics - June 24, 2023 Category: Physics Authors: S N Fedotov V V Kushin Source Type: research

Distributions of energy imparted to a micro-volume by secondary charged fragments of nuclear interactions in space radiation field
Radiat Environ Biophys. 2023 Jun 24. doi: 10.1007/s00411-023-01034-3. Online ahead of print.ABSTRACTThe field of cosmic radiation at low-Earth orbit (LEO) has a complex composition. It always contains a component of secondary charged particles, formed by the products of nuclear interactions of the primary high-energy radiation with the nuclei of spacecraft's shielding material, electronic components and biological matter on board. Generation of this secondary radiation can be observed in some track detectors in the form of "stars" formed by tracks-fragments with a common vertex. The energy absorbed by the medium in the reg...
Source: Radiation and Environmental Biophysics - June 24, 2023 Category: Physics Authors: S N Fedotov V V Kushin Source Type: research

Distributions of energy imparted to a micro-volume by secondary charged fragments of nuclear interactions in space radiation field
Radiat Environ Biophys. 2023 Jun 24. doi: 10.1007/s00411-023-01034-3. Online ahead of print.ABSTRACTThe field of cosmic radiation at low-Earth orbit (LEO) has a complex composition. It always contains a component of secondary charged particles, formed by the products of nuclear interactions of the primary high-energy radiation with the nuclei of spacecraft's shielding material, electronic components and biological matter on board. Generation of this secondary radiation can be observed in some track detectors in the form of "stars" formed by tracks-fragments with a common vertex. The energy absorbed by the medium in the reg...
Source: Radiation and Environmental Biophysics - June 24, 2023 Category: Physics Authors: S N Fedotov V V Kushin Source Type: research

Assessment of diagnostic reference levels for paediatric cardiac computed tomography in accordance with European guidelines
Radiat Environ Biophys. 2023 Jun 22. doi: 10.1007/s00411-023-01031-6. Online ahead of print.ABSTRACTRecently, paediatric cardiac computed tomography (CCT) has caused concerns that diagnostic image quality and dose reduction may require further improvement. Consequently, this study aimed to establish institutional (local) diagnostic reference levels (LDRLs) for CCT for paediatric patients, and assess the impact of tube voltage on proposed DRLs in terms of the volume computed tomography index (CTDIvol) and dose length product (DLP). In addition, effective doses (EDs) of exposure were estimated. A population of 453 infants, w...
Source: Radiation and Environmental Biophysics - June 22, 2023 Category: Physics Authors: Mohamed S Aboul Hamad Ehab M Attalla Hanan H Amer Mohamed M Fathy Source Type: research

Assessment of diagnostic reference levels for paediatric cardiac computed tomography in accordance with European guidelines
Radiat Environ Biophys. 2023 Jun 22. doi: 10.1007/s00411-023-01031-6. Online ahead of print.ABSTRACTRecently, paediatric cardiac computed tomography (CCT) has caused concerns that diagnostic image quality and dose reduction may require further improvement. Consequently, this study aimed to establish institutional (local) diagnostic reference levels (LDRLs) for CCT for paediatric patients, and assess the impact of tube voltage on proposed DRLs in terms of the volume computed tomography index (CTDIvol) and dose length product (DLP). In addition, effective doses (EDs) of exposure were estimated. A population of 453 infants, w...
Source: Radiation and Environmental Biophysics - June 22, 2023 Category: Physics Authors: Mohamed S Aboul Hamad Ehab M Attalla Hanan H Amer Mohamed M Fathy Source Type: research

Assessment of diagnostic reference levels for paediatric cardiac computed tomography in accordance with European guidelines
Radiat Environ Biophys. 2023 Jun 22. doi: 10.1007/s00411-023-01031-6. Online ahead of print.ABSTRACTRecently, paediatric cardiac computed tomography (CCT) has caused concerns that diagnostic image quality and dose reduction may require further improvement. Consequently, this study aimed to establish institutional (local) diagnostic reference levels (LDRLs) for CCT for paediatric patients, and assess the impact of tube voltage on proposed DRLs in terms of the volume computed tomography index (CTDIvol) and dose length product (DLP). In addition, effective doses (EDs) of exposure were estimated. A population of 453 infants, w...
Source: Radiation and Environmental Biophysics - June 22, 2023 Category: Physics Authors: Mohamed S Aboul Hamad Ehab M Attalla Hanan H Amer Mohamed M Fathy Source Type: research

The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
Radiat Environ Biophys. 2023 Jun 19. doi: 10.1007/s00411-023-01033-4. Online ahead of print.ABSTRACTCandidate ionising radiation exposure biomarkers must be validated in humans exposed in vivo. Blood from patients undergoing positron emission tomography-computed tomography scan (PET-CT) and skeletal scintigraphy (scintigraphy) was drawn before (0 h) and after (2 h) the procedure for correlation analyses of the response of selected biomarkers with radiation dose and other available patient information. FDXR, CDKN1A, BBC3, GADD45A, XPC, and MDM2 expression was determined by qRT-PCR, DNA damage (γH2AX) by flow cytometry, and...
Source: Radiation and Environmental Biophysics - June 19, 2023 Category: Physics Authors: Milagrosa L ópez-Riego Magdalena P łódowska Milena Lis-Zaj ęcka Kamila Jeziorska Sylwia Tetela Aneta W ęgierek-Ciuk Daniel Sobota Janusz Braziewicz Lovisa Lundholm Halina Lisowska Andrzej Wojcik Source Type: research

The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
Radiat Environ Biophys. 2023 Jun 19. doi: 10.1007/s00411-023-01033-4. Online ahead of print.ABSTRACTCandidate ionising radiation exposure biomarkers must be validated in humans exposed in vivo. Blood from patients undergoing positron emission tomography-computed tomography scan (PET-CT) and skeletal scintigraphy (scintigraphy) was drawn before (0 h) and after (2 h) the procedure for correlation analyses of the response of selected biomarkers with radiation dose and other available patient information. FDXR, CDKN1A, BBC3, GADD45A, XPC, and MDM2 expression was determined by qRT-PCR, DNA damage (γH2AX) by flow cytometry, and...
Source: Radiation and Environmental Biophysics - June 19, 2023 Category: Physics Authors: Milagrosa L ópez-Riego Magdalena P łódowska Milena Lis-Zaj ęcka Kamila Jeziorska Sylwia Tetela Aneta W ęgierek-Ciuk Daniel Sobota Janusz Braziewicz Lovisa Lundholm Halina Lisowska Andrzej Wojcik Source Type: research

The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
Radiat Environ Biophys. 2023 Jun 19. doi: 10.1007/s00411-023-01033-4. Online ahead of print.ABSTRACTCandidate ionising radiation exposure biomarkers must be validated in humans exposed in vivo. Blood from patients undergoing positron emission tomography-computed tomography scan (PET-CT) and skeletal scintigraphy (scintigraphy) was drawn before (0 h) and after (2 h) the procedure for correlation analyses of the response of selected biomarkers with radiation dose and other available patient information. FDXR, CDKN1A, BBC3, GADD45A, XPC, and MDM2 expression was determined by qRT-PCR, DNA damage (γH2AX) by flow cytometry, and...
Source: Radiation and Environmental Biophysics - June 19, 2023 Category: Physics Authors: Milagrosa L ópez-Riego Magdalena P łódowska Milena Lis-Zaj ęcka Kamila Jeziorska Sylwia Tetela Aneta W ęgierek-Ciuk Daniel Sobota Janusz Braziewicz Lovisa Lundholm Halina Lisowska Andrzej Wojcik Source Type: research

Fetal atomic bomb survivor dosimetry using the J45 series of pregnant female phantoms with realistic survivor exposure scenarios: comparisons to dose estimates in the DS02 system
Radiat Environ Biophys. 2023 Jun 9. doi: 10.1007/s00411-023-01032-5. Online ahead of print.ABSTRACTA significant source of information on radiation-induced biological effects following in-utero irradiation stems from studies of atomic bomb survivors who were pregnant at the time of exposure in Hiroshima, and to a lesser extent, from survivors in Nagasaki. Dose estimates to the developing fetus for these survivors have been assigned in prior dosimetry systems of the Radiation Effects Research Foundation as the dose to the uterine wall within the non-pregnant adult stylized phantom, originally designed for the dosimetry syst...
Source: Radiation and Environmental Biophysics - June 9, 2023 Category: Physics Authors: Colin J Paulbeck Tatsuhiko Sato Sachiyo Funamoto Choonsik Lee Keith T Griffin Harry M Cullings Stephen D Egbert Akira Endo Nolan E Hertel Wesley E Bolch Source Type: research