Protocol for Evaluating the Cardio-Ankle Vascular Index to Predict Cardiovascular Events in Japan: A Prospective Multicenter Cohort Study
The objective of this study was to examine the benefits of using CAVI as a predictor of cardiovascular events in high-risk patients.Methods and Design: This prospective multicenter study to evaluate the usefulness of the CAVI to predict cardiovascular events in Japan (CAVI-J) is a cohort study with central registration. Participants (n = 3,000) will be scheduled to enroll and data will be collected for up to 5 years from entry of participants into the study. To be eligible to participate in the CAVI-J study, individuals have to be aged between 40 and 74 years and have at least one of the following risk factors for arterios...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research
Cardio-Ankle Vascular Index in a Thai Population
Arterial stiffness as measured by the cardio-ankle vascular index (CAVI) is a widely available method in Thailand. Data from a large cross-sectional study revealed a significant correlation of CAVI and the presence of coronary artery disease as detected from 64-slice coronary computed tomography arteriography. Futhermore, CAVI was shown to predict long-term cardiovascular events in the patients with intermediate cardiovascular risk.Pulse 2016;4(suppl 1):8-10 (Source: Pulse)
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research
Arterial Stiffness: Recommendations and Standardization
The use of arterial stiffness measurements in longitudinal cohorts of normal populations, hypertensive patients, diabetic patients, healthy elderly, and patients on hemodialysis have confirmed the value of this important measure of arterial health, and established its complementary role to measures of blood pressure. Its contribution to understanding cardiovascular and mortality risk beyond blood pressure measurements has moved measures of arterial stiffness into the ranks of factors such as elevated cholesterol, diabetes, and left ventricular hypertrophy in considering cardiovascular risk. The recent international collabo...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research
New Epoch for Arterial Stiffness Measurement in the Clinic
Pulse 2016;4(suppl 1):1-2 (Source: Pulse)
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research
A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness
Conclusions: Although skin and plasma AGEs were similarly associated with gender and diabetes or prediabetes, they might measure something different and have different clinical relevance, such as for arterial stiffness.Pulse 2016;4:208-218 (Source: Pulse)
Source: Pulse - December 21, 2016 Category: Cardiology Source Type: research
Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes
There is a plausible physiological theory, supported by many observational studies, that vitamin D supplementation should be effective for improving cardiovascular end points, such as blood pressure (BP), large artery stiffness, atherosclerosis, endothelial function and clinical events. However, results from randomised controlled trials (RCTs) have been inconsistent. In this review, we evaluated the evidence regarding the effectiveness of vitamin D supplementation for cardiovascular surrogate and hard clinical end points. RCTs were assessed in terms of sample size, duration of supplementation, baseline vitamin D level incl...
Source: Pulse - December 8, 2016 Category: Cardiology Source Type: research
Cardiovascular Effects of Long-Term Vitamin D Supplementation: Summarised by Many but Studied by Few
Pulse 2016;4:172-174 (Source: Pulse)
Source: Pulse - December 7, 2016 Category: Cardiology Source Type: research
Large Artery Stiffness Assessment Using SphygmoCor Technology
This article briefly describes these parameters related to large artery stiffness and provides reference to validation and repeatability studies relative to the clinical use of the SphygmoCor devices. It is beyond the scope to review here the 424 original research articles that have employed SphygmoCor devices in measuring arterial stiffness. Instead, the method of measurement across the devices is described, including tonometry, volumetric displacement through cuff placement around limbs, and ambulatory monitoring. Key population and subpopulation studies are cited where the average stiffness parameter progression with ag...
Source: Pulse - November 30, 2016 Category: Cardiology Source Type: research
Estimated Pulse Wave Velocity Calculated from Age and Mean Arterial Blood Pressure
In a recently published paper, Greve et al [J Hypertens 2016;34:1279-1289] investigate whether the estimated carotid-femoral pulse wave velocity (ePWV), calculated using an equation derived from the relationship between carotid-femoral pulse wave velocity (cfPWV), age, and blood pressure, predicts cardiovascular disease (CVD) as good as the measured cfPWV. Because ePWV predicts CVD as good as cfPWV, some might wonder whether ePWV could be replaced by cfPWV, which is a time-consuming measurement requiring an expensive apparatus. This question is addressed in this mini-review.Pulse 2016;4:175-179 (Source: Pulse)
Source: Pulse - November 30, 2016 Category: Cardiology Source Type: research
Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study
Conclusion: The findings of the present study suggest that polymorphism in the C148T position of the β-fibrinogen gene might be a risk factor for IS mainly for the small vessel disease stroke subtype in a North Indian population. Further, large prospective studies are required to confirm these findings.Pulse 2016;4:165-171 (Source: Pulse)
Source: Pulse - October 11, 2016 Category: Cardiology Source Type: research
The Pulse of Asia 2016 Seoul, September 24-26, 2016, Seoul, Republic of Korea: Abstracts
Pulse 2016;4:93-164 (Source: Pulse)
Source: Pulse - September 12, 2016 Category: Cardiology Source Type: research
Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis
Conclusion: Our meta-analysis suggests that IL-6 gene polymorphisms are not associated with the risk of ICH. However, caution must be taken while considering the results of our meta-analysis due to the presence of small sample size. Our results cannot be extrapolated to represent the effect of entire IL-6 genetic polymorphism on stroke patients worldwide. Therefore, further well-designed studies with large sample size are warranted to validate our findings and provide a profound conclusion.Pulse 2016;4:61-68 (Source: Pulse)
Source: Pulse - July 13, 2016 Category: Cardiology Source Type: research
The J-Curve Phenomenon in Hypertension
Almost immediately after antihypertensive therapy was proven effective in preventing cardiovascular events, the J-curve issue emerged as a hot topic. The Hypertension Optimal Treatment (HOT) trial attempted to address this question (diastolic blood pressure (Source: Pulse)
Source: Pulse - June 17, 2016 Category: Cardiology Source Type: research
Molecular Mechanisms of Arterial Stiffening
Stiffening of large arteries is a hallmark of vascular aging and one of the most important determinants of the age-related increase in blood pressure and cardiovascular disease events. Despite a substantial genetic component, the molecular mechanisms underlying phenotypic variability in arterial stiffness remain unknown. Previous genetic studies have identified several genetic variants that are associated with measures of arterial stiffness. Here, we review the relevant advances in the identification of pathways underlying arterial stiffness from genomic studies.Pulse 2016;4:43-48 (Source: Pulse)
Source: Pulse - May 18, 2016 Category: Cardiology Source Type: research
Within-Home Blood Pressure Variability on a Single Occasion Has Clinical Significance
There is growing evidence that diversely defined blood pressure variability (BPV) is an independent predictor of hypertensive target organ damage (TOD) and cardiovascular events. Several mechanisms have been speculated to underlie episodes of increased BPV, including the impairment of autonomic or hormonal regulation, renal dysfunction, and increased arterial stiffness. Within-home BPV, defined as differences in BP values obtained on a single occasion at home, could have prognostic significance for hypertensive TOD. It is typically thought that BP values are decreased with repeated measurements on a single occasion at home...
Source: Pulse - May 11, 2016 Category: Cardiology Source Type: research
