Population Pharmacokinetics of Moxifloxacin in Children
ConclusionThese data add to the existing literature to support use of moxifloxacin in children in certain situations; however, further prospective studies on the safety and efficacy of moxifloxacin are needed. (Source: Pediatric Drugs)
Source: Pediatric Drugs - March 14, 2022 Category: Pediatrics Source Type: research
Efficacy and Costs of Three Pharmacotherapies for Patent Ductus Arteriosus Closure in Premature Infants
ConclusionsOur meta-analysis suggests acetaminophen is non-inferior to both indomethacin and ibuprofen, and costs relatively less for successful PDA constriction in premature infants. Further clinical trials are warranted to compare acetaminophen ’s safety, along with short- and long-term effects, to help resolve the clinical conundrum of the necessity of early treatment in the management of PDA, and the optimal pharmacological course, if indicated. (Source: Pediatric Drugs)
Source: Pediatric Drugs - March 1, 2022 Category: Pediatrics Source Type: research
Effect of Mirtazapine on Nausea in Children with Functional Nausea and Functional Dyspepsia Postprandial Distress Syndrome
ConclusionsMirtazapine is an option for treating children and adolescents with functional nausea and nausea associated with functional dyspepsia post-prandial distress syndrome, especially for a select group of patients with concurrent weight loss, anxiety, and insomnia. (Source: Pediatric Drugs)
Source: Pediatric Drugs - February 21, 2022 Category: Pediatrics Source Type: research
Acute Tolerability of Methylphenidate in Treatment-Na ïve Children with ADHD: An Analysis of Naturalistically Collected Data from Clinical Practice
ConclusionsAmong stimulant-na ïve children in clinical practice, the incidence of acute MPH intolerance can be estimated to be between 1.2 and 4.1%. An asymptomatic elevation in cardiovascular parameters can be observed in about 1 out of 10 children and warrants monitoring during ongoing treatment. (Source: Pediatric Drugs)
Source: Pediatric Drugs - February 9, 2022 Category: Pediatrics Source Type: research
Safety of Ferric Carboxymaltose in Children: Report of a Case Series from Greece and Review of the Literature
ConclusionsOur patient cohort and this literature review provide further evidence for the good safety profile of FCM in children, although well-designed prospective clinical trials with appropriate safety endpoints are still required. (Source: Pediatric Drugs)
Source: Pediatric Drugs - January 27, 2022 Category: Pediatrics Source Type: research
Drug Treatment of Heart Failure in Children: Gaps and Opportunities
AbstractMedical therapy for pediatric heart failure is based on a detailed mechanistic understanding of the underlying causes, which are diverse and unlike those encountered in most adult patients. Diuresis and improved perfusion are the immediate goals of care in the child with acute decompensated heart failure. Conversion to maintenance oral therapy for heart failure is based on the results of landmark studies in adults, as well as recent pediatric clinical trials and heart failure guidelines. There will continue to be an important role for newer drugs, some of which are in active trials in adults, and some of which are ...
Source: Pediatric Drugs - January 27, 2022 Category: Pediatrics Source Type: research
Drug Treatment of Low Bone Mass and Other Bone Conditions in Pediatric Patients
AbstractOsteoporosis may affect young individuals, albeit infrequently. In childhood, bone mass increases, reaching its peak between the second and third decades; then, after a period of stability, it gradually declines. Several conditions, including genetic disorders, chronic diseases, and some medications, can have an impact on bone homeostasis. Diagnosis in young patients is based on the criteria defined by the International Society for Clinical Densitometry (ISCD), published in 2013. High risk factors should be identified and monitored. Often simple interventions aimed to eliminate the underlying cause, to minimize the...
Source: Pediatric Drugs - January 11, 2022 Category: Pediatrics Source Type: research
Prucalopride for Treatment of Upper Gastrointestinal Symptoms in Children
ConclusionsIn this sample of children treated for refractory upper GI symptoms at a single tertiary care center, patients showed improvements in symptoms like nausea, reflux, and feeding difficulties after starting prucalopride. (Source: Pediatric Drugs)
Source: Pediatric Drugs - December 23, 2021 Category: Pediatrics Source Type: research
Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol
ConclusionsAppropriate implementation of the 2015 HBP in the pediatric ward improves the use of medication and chest X-ray without modifying clinical outcomes. However, further efforts are needed to reduce the use of salbutamol, corticosteroids, and blood tests. (Source: Pediatric Drugs)
Source: Pediatric Drugs - December 22, 2021 Category: Pediatrics Source Type: research
Real-Life Use of Biosimilars in Pediatric Inflammatory Bowel Disease: A Nation-Wide Web Survey on Behalf of the SIGENP IBD Working Group
ConclusionsA few years after the introduction of the first biosimilar into the market, real-life data coming from the major IBD units in Italy confirm a favorable and confident position on the use of biosimilars in pediatric IBD. (Source: Pediatric Drugs)
Source: Pediatric Drugs - December 16, 2021 Category: Pediatrics Source Type: research
Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects
AbstractPediatric antiphospholipid syndrome (APS) is a rare acquired multisystem autoimmune thromboinflammatory condition characterized by thrombotic and non-thrombotic clinical manifestations. APS in children and adolescents typically presents with large-vessel thrombosis, thrombotic microangiopathy, and, rarely, obstetric morbidity. Non-thrombotic clinical manifestations are frequently seen in pediatric APS and may be present even before the vascular thrombotic events occur. We review insights into the pathogenesis of APS and discuss potential targets for therapy. The identification of multiple immunologic abnormalities ...
Source: Pediatric Drugs - December 13, 2021 Category: Pediatrics Source Type: research
Metamizole Use in Children: Analysis of Drug Utilisation and Adverse Drug Reactions at a German University Hospital between 2015 and 2020
DiscussionMetamizole is commonly used in paediatric inpatients in Germany. Serious ADRs occur but rarely. Continuous monitoring of drug therapy through, for example, stimulated reporting systems ensures that serious ADRs are detected, and appropriate interventions can be introduced. (Source: Pediatric Drugs)
Source: Pediatric Drugs - December 8, 2021 Category: Pediatrics Source Type: research
Immunotherapies for Pediatric Solid Tumors: A Targeted Update
AbstractThere are encouraging signs in our collective progress to leverage the immune system to treat pediatric cancers. Here, we summarize interim successes in cancer immunotherapy and opportunities to translate from the adult world to pediatrics, and highlight challenges that could benefit from additional development, focusing on solid tumors. Just a decade ago, other than antibodies targeting disialoganglioside (GD2) in neuroblastoma, pediatric cancer immunotherapy was mostly relegated to obscure preclinical studies in a few academic labs. Today there are numerous clinical trials of a variety of antibody, cellular, gene...
Source: Pediatric Drugs - November 25, 2021 Category: Pediatrics Source Type: research
Correction to: Secukinumab: A Review in Moderate to Severe Pediatric Plaque Psoriasis
(Source: Pediatric Drugs)
Source: Pediatric Drugs - November 18, 2021 Category: Pediatrics Source Type: research
Lonapegsomatropin: Pediatric First Approval
This article summarize s the milestones in the development of lonapegsomatropin leading to this first pediatric approval for the treatment of growth hormone deficiency. (Source: Pediatric Drugs)
Source: Pediatric Drugs - October 28, 2021 Category: Pediatrics Source Type: research
