Real-world evidence study on tolerance and growth in infants fed an infant formula with two human milk oligosaccharides vs mixed fed and exclusively breastfed infants
ConclusionsIn this RWE study examining an infant formula with HMOs, growth and GI tolerance outcomes were confirming the good tolerance and safety of this early feeding option previously reported in RCTs. (Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - August 19, 2023 Category: Cytology Source Type: research
Metamizole-induced agranulocytosis (MIA): a mini review
AbstractMetamizole is an analgesic, antipyretic, and spasmolytic drug in Germany only approved for the treatment of severe pain or high fever that does not respond to other measures. In recent years, an increased use has been described among both adults and children, often against the approved indication. The most important side effect of metamizole is the development of agranulocytosis (neutrophil count < 500/µL). Incidence of metamizole-induced agranulocytosis (MIA) ranges depending on the study from 0.96 cases per million per year to 1:1602 per patient and metamizole prescription. The risk of agranulocytosis i...
Source: Molecular and Cellular Pediatrics - August 17, 2023 Category: Cytology Source Type: research
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
AbstractSystemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15 –20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE). Patients with jSLE exhibit more variable and severe disease when compared to patients with disease-onset during adulthood. Neuropsychiatric (NP) involvement is a clinically heterogenous and potentia lly severe complication. Published reports on the incidence and prevalence of NP-jSLE are scarce, and the exact pathophysiology is poorly understood.This manuscript provides a review of...
Source: Molecular and Cellular Pediatrics - August 9, 2023 Category: Cytology Source Type: research
Perinatal origins of bronchopulmonary dysplasia —deciphering normal and impaired lung development cell by cell
AbstractBronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD morbidity and severity depend on a complex interplay between prenatal and postnatal inflammation, mechanical ventilation, and oxygen therapy as well as associated prematurity-related complications. These initial hits result in ill-explored aberrant immune and reparative response, activation of pro-fibrotic and anti-angiogenic factors, which further perpetuate the injury. Histologically, the disease presents primarily by impaired lung develo...
Source: Molecular and Cellular Pediatrics - April 18, 2023 Category: Cytology Source Type: research
New insights into the immune functions of podocytes: the role of complement
AbstractPodocytes are differentiated epithelial cells which play an essential role to ensure a normal function of the glomerular filtration barrier (GFB). In addition to their adhesive properties in maintaining the integrity of the filtration barrier, they have other functions, such as synthesis of components of the glomerular basement membrane (GBM), production of vascular endothelial growth factor (VEGF), release of inflammatory proteins, and expression of complement components. They also participate in the glomerular crosstalk through multiple signalling pathways, including endothelin-1, VEGF, transforming growth factor...
Source: Molecular and Cellular Pediatrics - April 15, 2023 Category: Cytology Source Type: research
Modelling human lower urinary tract malformations in zebrafish
AbstractAdvances in molecular biology are improving our understanding of the genetic causes underlying human congenital lower urinary tract (i.e., bladder and urethral) malformations. This has recently led to the identification of the first disease-causing variants in the geneBNC2 for isolated lower urinary tract anatomical obstruction (LUTO), and ofWNT3 andSLC20A1 as genes implicated in the pathogenesis of the group of conditions called bladder-exstrophy-epispadias complex (BEEC). Implicating candidate genes from human genetic data requires evidence of their influence on lower urinary tract development and evidence of the...
Source: Molecular and Cellular Pediatrics - March 29, 2023 Category: Cytology Source Type: research
Umbilical catheter placement aided by coronary guidewires
AbstractCatheterization of the umbilical vessels has proven to be an effective and relatively rapid method for gaining central vascular access in neonates. However, it can be technically difficult, the procedure may last 30 min or longer, and it can be associated with complications in some patients. We suggest using a coronary guidewire during catheterization of umbilical vessels to support the placement of umbilical catheters and significantly reduce a risk for complications. We tested the proposed technique in 6 successful ex vivo bench tests of catheterization of the umbilical vessels in stillborn piglets immediately af...
Source: Molecular and Cellular Pediatrics - March 14, 2023 Category: Cytology Source Type: research
Non-invasive pediatric cardiac imaging —current status and further perspectives
ConclusionNon-invasive cardiac imaging plays an integral part in the workup of children with heart disease. In recent years, its main application congenital heart disease has been widened for acquired cardiac diseases. (Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - December 28, 2022 Category: Cytology Source Type: research
Adsorption of insulin onto neonatal infusion sets: should intravenous administration of insulin to treat hyperglycemia in preterm babies on the NICU be proceeded by priming of the intravenous system, adding of albumin, or non-priming to get to a stable insulin dose?
AbstractInsulin is used to treat neonatal hyperglycaemia when blood glucose concentrations are consistently high, and to treat neonatal diabetes. Within this brief report, a review of the existing literature is conducted to determine if intravenous administration of insulin should be proceeded by priming of the intravenous system, adding of albumin, or non-priming to get a stable insulin dose. Within this literature search, we focused on experimental insulin adsorption data (in vitro studies). (Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - December 21, 2022 Category: Cytology Source Type: research
Molecular detection and characterization of Shigella spp. harboring extended-spectrum β-lactamase genes in children with diarrhea in northwest Iran
AbstractShigellosis is one of the acute bowel infections and remains a serious public health problem in resource-poor countries. The present study aimed to survey the distribution of extended-spectrum β-lactamase (ESBL)-producingShigella strains isolated from patients with diarrhea in northwest Iran. In the present cross-sectional study, from January 2019 to December 2020, 1280 fecal samples were collected from children with diarrhea in Ardabil, Iran. Multiplex PCR assay was applied for the presence ofipaH,invC,wbgZ,rfpB, andrfc genes to detectShigella spp.,Shigella sonnei,Shigella dysenteriae,Shigella flexneri, andShigel...
Source: Molecular and Cellular Pediatrics - December 8, 2022 Category: Cytology Source Type: research
Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology
ConclusionWe identified that maternal, birth characteristics and therapeutic measures are probably risk factors for SCFN. These risk factors should be taken into account within the care of neonates. (Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - November 24, 2022 Category: Cytology Source Type: research
The interstitium at the developing nephron in the fetal kidney during advanced pregnancy — a microanatomical inventory
ConclusionsThe present investigation illustrates that the interstitium at the forming nephron in the fetal kidney consists of existing, transient, stage-specific, and differently far matured compartments. According to the developmental needs, it changes its shape by formation, degradation, fusion, and rebuilding. (Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - August 26, 2022 Category: Cytology Source Type: research
Association of immune cell recruitment and BPD development
AbstractIn the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focus of many studies has been the characteristic inflammatory responses provoked by these exposures. Here, we review the relationship between immaturity and prenatal conditions, as well as postnatal exposure to mechanical ventilation and oxygen toxicity, with the imbalance of pro- and anti-inflammatory regulatory networks. In these conditions, cytokine release, protease activity, and sustained presence of innate ...
Source: Molecular and Cellular Pediatrics - August 2, 2022 Category: Cytology Source Type: research
Correction: Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition
(Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - July 23, 2022 Category: Cytology Source Type: research
Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition
AbstractHuman milk contains more than 150 different oligosaccharides, which together are among to the quantitatively predominant solid components of breast milk. The oligosaccharide content and composition of human milk show large inter-individual differences. Oligosaccharide content is mostly influenced by genetic variants of the mother ’s secretor status. Oligosaccharides in human milk are utilized by infants’ intestinal bacteria, affecting bacterial composition and metabolic activity. Maternal secretor status, and respective differing fucosylated oligosaccharide content, has been associated both with reduced and inc...
Source: Molecular and Cellular Pediatrics - July 13, 2022 Category: Cytology Source Type: research
