Challenges in integrating molecular profiles into clinical cancer care
SummaryProfiling of malignancies with next-generation sequencing (NGS) is now routine in clinical practice. While many cases of approved targeted therapies are straightforward based on well-characterized alterations, applying large NGS multigene panels to therapeutic use is frequently challenging. In this article, variant interpretation, therapy matching, and final treatment selection challenges are discussed. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - October 6, 2022 Category: Cancer & Oncology Source Type: research

Dual checkpoint-blockade in urothelial carcinoma —when is it so far
SummarySingle agent immunotherapy is routinely used in the treatment of localised and advanced bladder cancer. Dual checkpoint inhibition with nivolumab (nivo) –ipilimumab (ipi) and durvalumab (durva)–tremelimumab (treme) shows encouraging activity in phase I/II trials in the neoadjuvant and metastatic disease setting. Several large trials are testing these combinations against the current standard of care. The so far reported results are negative; ho wever, it appears that a subgroup of patients might profit substantially from dual checkpoint blockade. Ongoing trials will elucidate which patients will be candidates f...
Source: Memo - Magazine of European Medical Oncology - October 6, 2022 Category: Cancer & Oncology Source Type: research

Challenges in integrating molecular profiles into clinical cancer care
SummaryProfiling of malignancies with next-generation sequencing (NGS) is now routine in clinical practice. While many cases of approved targeted therapies are straightforward based on well-characterized alterations, applying large NGS multigene panels to therapeutic use is frequently challenging. In this article, variant interpretation, therapy matching, and final treatment selection challenges are discussed. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - October 6, 2022 Category: Cancer & Oncology Source Type: research

Dual checkpoint-blockade in urothelial carcinoma —when is it so far
SummarySingle agent immunotherapy is routinely used in the treatment of localised and advanced bladder cancer. Dual checkpoint inhibition with nivolumab (nivo) –ipilimumab (ipi) and durvalumab (durva)–tremelimumab (treme) shows encouraging activity in phase I/II trials in the neoadjuvant and metastatic disease setting. Several large trials are testing these combinations against the current standard of care. The so far reported results are negative; ho wever, it appears that a subgroup of patients might profit substantially from dual checkpoint blockade. Ongoing trials will elucidate which patients will be candidates f...
Source: Memo - Magazine of European Medical Oncology - October 6, 2022 Category: Cancer & Oncology Source Type: research

A GLOBAL CONGRESS DIGEST ON TARGETED AND IMMUNE-DIRECTED THERAPIES IN HAEMATOLOGICAL MALIGNANCIES. Report from the American Society of Clinical Oncology (ASCO) Annual Meeting (hybrid), 2nd –6th June 2022, and the 30th European Hematology Association (EHA) 2022 Congress (hybrid), 9th–12th June 2022
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - October 5, 2022 Category: Cancer & Oncology Source Type: research

Bilateral primary breast lymphoma in a  pregnant woman: a case report and literature review
We reported herein a case of bilateral primary breast lymphoma in a 35-year-old pregnant woman. After the diagnosis of DLBCL, R‑CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) was started in the second trimester. Postpartum intr athecal methotrexate prophylaxis and adjuvant radiotherapy were applied and a complete response was obtained. Twelve months after the initial diagnosis, our patient remains alive and relapse-free. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - October 4, 2022 Category: Cancer & Oncology Source Type: research

A GLOBAL CONGRESS DIGEST ON TARGETED AND IMMUNE-DIRECTED THERAPIES IN HAEMATOLOGICAL MALIGNANCIES. Report from the American Society of Clinical Oncology (ASCO) Annual Meeting (hybrid), 2nd –6th June 2022, and the 30th European Hematology Association (EHA) 2022 Congress (hybrid), 9th–12th June 2022
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - October 1, 2022 Category: Cancer & Oncology Source Type: research

A GLOBAL CONGRESS DIGEST ON SOLID TUMORS. Report from the ASCO Hybrid Congress , 3rd – 7th June 2022
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - October 1, 2022 Category: Cancer & Oncology Source Type: research

Neoadjuvant treatment for solid tumors —the earlier, the better
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - September 1, 2022 Category: Cancer & Oncology Source Type: research

Molecular profiling leading to personalized cancer treatment
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - September 1, 2022 Category: Cancer & Oncology Source Type: research

CAR-T cells —Real-time experience applying CAR-T cells—What we have learned so far
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - September 1, 2022 Category: Cancer & Oncology Source Type: research

Neoadjuvant treatment for solid tumors —the earlier, the better
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - September 1, 2022 Category: Cancer & Oncology Source Type: research

Molecular profiling leading to personalized cancer treatment
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - September 1, 2022 Category: Cancer & Oncology Source Type: research