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Current systemic treatment options and new developments in palliative first-line treatment of head and neck squamous cell carcinoma
SummaryThis short review gives an overview of current treatment concepts, recently published trials, and novel developments in relapsed or metastatic head and neck squamous cell carcinoma (HNSCC) not amendable for local curative treatment. Trials with potential future clinical implications and relevant updates of landmark trials are provided as well. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - July 28, 2023 Category: Cancer & Oncology Source Type: research

Next generation drugs in urothelial cancer: adenoviruses in the treatment of BCG-unresponsive nonmuscle invasive bladder cancer
SummaryTreatment options for nonmuscle invasive urothelial carcinoma of the bladder (NMIBC) unresponsive to Bacillus Calmette-Gu érin (BCG) instillations are currently limited and often total resection of the bladder is the only therapeutic option for these patients. Thus, novel treatment options that are safe and effective are needed to avoid the substantial treatment morbidity, impact on the quality of life and the signifi cant surgical risk associated with radical cystectomies. Besides intravesical cytotoxic therapies, immune checkpoint inhibitors, cytokines or cancer vaccines, different approaches of intravesical appl...
Source: Memo - Magazine of European Medical Oncology - July 25, 2023 Category: Cancer & Oncology Source Type: research

Lipid nanoparticles in the treatment of lung cancer —hype or hope?
SummaryLung cancer is still one of the most common cancer entities worldwide and the leading cause of cancer mortality. Despite significant advances in the diagnosis and therapy of lung cancer, many patients do not respond to existing therapies, indicating an urgent need for the development of novel treatment strategies. In recent years, nanotechnology has led to significant progress in modern medicine. Especially lipid nanoparticles (LNPs) evoked substantial interest, due to their broad application as coronavirus disease 2019 (COVID-19) vaccines. In the future of lung cancer treatment, lipid nanoparticles hold the potenti...
Source: Memo - Magazine of European Medical Oncology - July 24, 2023 Category: Cancer & Oncology Source Type: research

ASH highlights 2022 —multiple myeloma
SummaryThe 64th annual meeting was held in New Orleans, Louisiana from December 10 –13, 2022. More than 150 abstracts concerning multiple myeloma have been presented, mirroring the rapid progression, and deepening of our understanding of this disease.Evolution in treatment options includes new therapeutic regimens incorporating established drugs as well as entirely newly discovered substances, targeting malignant plasma cells utilizing the power of the immune system. In the following, a personal shortcut of hot topics is presented, focusing on data from large clinical trials which have the potency to change clinical prac...
Source: Memo - Magazine of European Medical Oncology - July 22, 2023 Category: Cancer & Oncology Source Type: research

Hepatosplenic T-cell lymphoma with hemophagocytic lymphohistiocytosis, revealed by fever of unknown origin
In this report, we discuss a case of HSTCL with hemophagocytic lymphohistiocytosis that was discovered due to a prolonged fever in a 27-year-old woman with no prior medical history. Infectious and autoimmune diseases were ruled out during t he etiological review. Histopathological analysis of the bone marrow revealed hemophagocytosis. A diagnostic splenectomy was performed after the patient’s clinical condition worsened, showing no response to corticosteroids, and notable splenomegaly and hepatomegaly were observed on the positron e mission tomography (PET) scan. The diagnosis of HSTCL was confirmed through pathologi...
Source: Memo - Magazine of European Medical Oncology - July 5, 2023 Category: Cancer & Oncology Source Type: research

ASH 2022 —new developments in acute myeloid leukemia
SummaryRecent years have provided progress for the treatment of acute myeloid leukemia (AML) patients by translating insights from basic research on AML biology into new drugs and concepts. The latest developments presented at the 2022 annual meeting of the American Society of Hematology (ASH) are covered in this review, including discussion of new classifications, treatment of elderly unfit patients, and new approaches towards allogeneic transplantation. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - June 20, 2023 Category: Cancer & Oncology Source Type: research

Esmo 2022
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - May 26, 2023 Category: Cancer & Oncology Source Type: research

Colorectal cancer special, part  2
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - May 26, 2023 Category: Cancer & Oncology Source Type: research

Esmo 2022
(Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research