Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case
In conclusion, the analysis of adverse health outcomes in relation to omics biomarkers rests on the same statistical principle as any other data collected in large population or patient cohorts. The large number of biomarkers, which have to be considered simultaneously requires planning ahead how the study database will be structured and curated, imported in statistical software packages, analysis results will be triaged for clinical relevance, and presented.PMID:37143314 | DOI:10.1002/mas.21849 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 5, 2023 Category: Molecular Biology Authors: De-Wei An Yu-Ling Yu Dries S Martens Agnieszka Latosinska Zhen-Yu Zhang Harald Mischak Tim S Nawrot Jan A Staessen Source Type: research
Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case
In conclusion, the analysis of adverse health outcomes in relation to omics biomarkers rests on the same statistical principle as any other data collected in large population or patient cohorts. The large number of biomarkers, which have to be considered simultaneously requires planning ahead how the study database will be structured and curated, imported in statistical software packages, analysis results will be triaged for clinical relevance, and presented.PMID:37143314 | DOI:10.1002/mas.21849 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 5, 2023 Category: Molecular Biology Authors: De-Wei An Yu-Ling Yu Dries S Martens Agnieszka Latosinska Zhen-Yu Zhang Harald Mischak Tim S Nawrot Jan A Staessen Source Type: research
Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case
In conclusion, the analysis of adverse health outcomes in relation to omics biomarkers rests on the same statistical principle as any other data collected in large population or patient cohorts. The large number of biomarkers, which have to be considered simultaneously requires planning ahead how the study database will be structured and curated, imported in statistical software packages, analysis results will be triaged for clinical relevance, and presented.PMID:37143314 | DOI:10.1002/mas.21849 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 5, 2023 Category: Molecular Biology Authors: De-Wei An Yu-Ling Yu Dries S Martens Agnieszka Latosinska Zhen-Yu Zhang Harald Mischak Tim S Nawrot Jan A Staessen Source Type: research
Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case
In conclusion, the analysis of adverse health outcomes in relation to omics biomarkers rests on the same statistical principle as any other data collected in large population or patient cohorts. The large number of biomarkers, which have to be considered simultaneously requires planning ahead how the study database will be structured and curated, imported in statistical software packages, analysis results will be triaged for clinical relevance, and presented.PMID:37143314 | DOI:10.1002/mas.21849 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - May 5, 2023 Category: Molecular Biology Authors: De-Wei An Yu-Ling Yu Dries S Martens Agnieszka Latosinska Zhen-Yu Zhang Harald Mischak Tim S Nawrot Jan A Staessen Source Type: research
Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions
Mass Spectrom Rev. 2023 May 2. doi: 10.1002/mas.21847. Online ahead of print.ABSTRACTCollision cross-section values, which can be determined using ion mobility experiments, are sensitive to the structures of protein ions and useful for applications to structural biology and biophysics. Protein ions with different charge states can exhibit very different collision cross-section values, but a comprehensive understanding of this relationship remains elusive. Here, we review cation-to-anion, proton-transfer reactions (CAPTR), a method for generating a series of charge-reduced protein cations by reacting quadrupole-selected cat...
Source: Mass Spectrometry Reviews - May 2, 2023 Category: Molecular Biology Authors: Theresa A Gozzo Matthew F Bush Source Type: research
Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions
Mass Spectrom Rev. 2023 May 2. doi: 10.1002/mas.21847. Online ahead of print.ABSTRACTCollision cross-section values, which can be determined using ion mobility experiments, are sensitive to the structures of protein ions and useful for applications to structural biology and biophysics. Protein ions with different charge states can exhibit very different collision cross-section values, but a comprehensive understanding of this relationship remains elusive. Here, we review cation-to-anion, proton-transfer reactions (CAPTR), a method for generating a series of charge-reduced protein cations by reacting quadrupole-selected cat...
Source: Mass Spectrometry Reviews - May 2, 2023 Category: Molecular Biology Authors: Theresa A Gozzo Matthew F Bush Source Type: research
Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions
Mass Spectrom Rev. 2023 May 2. doi: 10.1002/mas.21847. Online ahead of print.ABSTRACTCollision cross-section values, which can be determined using ion mobility experiments, are sensitive to the structures of protein ions and useful for applications to structural biology and biophysics. Protein ions with different charge states can exhibit very different collision cross-section values, but a comprehensive understanding of this relationship remains elusive. Here, we review cation-to-anion, proton-transfer reactions (CAPTR), a method for generating a series of charge-reduced protein cations by reacting quadrupole-selected cat...
Source: Mass Spectrometry Reviews - May 2, 2023 Category: Molecular Biology Authors: Theresa A Gozzo Matthew F Bush Source Type: research
Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: future challenges and perspectives
This article is protected by copyright. All rights reserved.PMID:37102760 | DOI:10.1002/mas.21848 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - April 27, 2023 Category: Molecular Biology Authors: Siddabasave Gowda B Gowda Chandra Shekhar Divyavani Gowda Yifan Chen Hitoshi Chiba Shu-Ping Hui Source Type: research
Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: future challenges and perspectives
This article is protected by copyright. All rights reserved.PMID:37102760 | DOI:10.1002/mas.21848 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - April 27, 2023 Category: Molecular Biology Authors: Siddabasave Gowda B Gowda Chandra Shekhar Divyavani Gowda Yifan Chen Hitoshi Chiba Shu-Ping Hui Source Type: research
Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: future challenges and perspectives
This article is protected by copyright. All rights reserved.PMID:37102760 | DOI:10.1002/mas.21848 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - April 27, 2023 Category: Molecular Biology Authors: Siddabasave Gowda B Gowda Chandra Shekhar Divyavani Gowda Yifan Chen Hitoshi Chiba Shu-Ping Hui Source Type: research
Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: future challenges and perspectives
This article is protected by copyright. All rights reserved.PMID:37102760 | DOI:10.1002/mas.21848 (Source: Mass Spectrometry Reviews)
Source: Mass Spectrometry Reviews - April 27, 2023 Category: Molecular Biology Authors: Siddabasave Gowda B Gowda Chandra Shekhar Divyavani Gowda Yifan Chen Hitoshi Chiba Shu-Ping Hui Source Type: research
Mass spectrometry of polymers: A tutorial review
Mass Spectrom Rev. 2023 Apr 18. doi: 10.1002/mas.21844. Online ahead of print.ABSTRACTEver since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in-depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with ...
Source: Mass Spectrometry Reviews - April 18, 2023 Category: Molecular Biology Authors: Chrys Wesdemiotis Kayla N Williams-Pavlantos Addie R Keating Andrew S McGee Calum Bochenek Source Type: research
Mass spectrometry of polymers: A tutorial review
Mass Spectrom Rev. 2023 Apr 18. doi: 10.1002/mas.21844. Online ahead of print.ABSTRACTEver since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in-depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with ...
Source: Mass Spectrometry Reviews - April 18, 2023 Category: Molecular Biology Authors: Chrys Wesdemiotis Kayla N Williams-Pavlantos Addie R Keating Andrew S McGee Calum Bochenek Source Type: research
Mass spectrometry of polymers: A tutorial review
Mass Spectrom Rev. 2023 Apr 18. doi: 10.1002/mas.21844. Online ahead of print.ABSTRACTEver since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in-depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with ...
Source: Mass Spectrometry Reviews - April 18, 2023 Category: Molecular Biology Authors: Chrys Wesdemiotis Kayla N Williams-Pavlantos Addie R Keating Andrew S McGee Calum Bochenek Source Type: research
Mass spectrometry of polymers: A tutorial review
Mass Spectrom Rev. 2023 Apr 18. doi: 10.1002/mas.21844. Online ahead of print.ABSTRACTEver since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in-depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with ...
Source: Mass Spectrometry Reviews - April 18, 2023 Category: Molecular Biology Authors: Chrys Wesdemiotis Kayla N Williams-Pavlantos Addie R Keating Andrew S McGee Calum Bochenek Source Type: research
