Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Miniature mass spectrometers and their potential for clinical point-of-care analysis
Mass Spectrom Rev. 2023 Aug 23. doi: 10.1002/mas.21867. Online ahead of print.ABSTRACTMass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advance...
Source: Mass Spectrometry Reviews - August 23, 2023 Category: Molecular Biology Authors: Yanbing Zhai Xinyan Fu Wei Xu Source Type: research
Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine
Mass Spectrom Rev. 2023 Aug 20. doi: 10.1002/mas.21866. Online ahead of print.ABSTRACTDirect analysis in real time (DART) represents a new generation of ionization techniques that are used to rapidly ionize small molecules under ambient environments. The combination of DART with various mass spectrometry (MS) instruments allows analyzing multiple plant materials, including traditional Chinese herbal medicines (TCHMs), under simple or no sample treatment conditions. This review discussed the DART principles, including devices, ionization mechanisms, and operation parameters. Typical spectra detected by DART-MS were exhibite...
Source: Mass Spectrometry Reviews - August 20, 2023 Category: Molecular Biology Authors: Yang Wang Shuying Liu Source Type: research
Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine
Mass Spectrom Rev. 2023 Aug 20. doi: 10.1002/mas.21866. Online ahead of print.ABSTRACTDirect analysis in real time (DART) represents a new generation of ionization techniques that are used to rapidly ionize small molecules under ambient environments. The combination of DART with various mass spectrometry (MS) instruments allows analyzing multiple plant materials, including traditional Chinese herbal medicines (TCHMs), under simple or no sample treatment conditions. This review discussed the DART principles, including devices, ionization mechanisms, and operation parameters. Typical spectra detected by DART-MS were exhibite...
Source: Mass Spectrometry Reviews - August 20, 2023 Category: Molecular Biology Authors: Yang Wang Shuying Liu Source Type: research
Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine
Mass Spectrom Rev. 2023 Aug 20. doi: 10.1002/mas.21866. Online ahead of print.ABSTRACTDirect analysis in real time (DART) represents a new generation of ionization techniques that are used to rapidly ionize small molecules under ambient environments. The combination of DART with various mass spectrometry (MS) instruments allows analyzing multiple plant materials, including traditional Chinese herbal medicines (TCHMs), under simple or no sample treatment conditions. This review discussed the DART principles, including devices, ionization mechanisms, and operation parameters. Typical spectra detected by DART-MS were exhibite...
Source: Mass Spectrometry Reviews - August 20, 2023 Category: Molecular Biology Authors: Yang Wang Shuying Liu Source Type: research
Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine
Mass Spectrom Rev. 2023 Aug 20. doi: 10.1002/mas.21866. Online ahead of print.ABSTRACTDirect analysis in real time (DART) represents a new generation of ionization techniques that are used to rapidly ionize small molecules under ambient environments. The combination of DART with various mass spectrometry (MS) instruments allows analyzing multiple plant materials, including traditional Chinese herbal medicines (TCHMs), under simple or no sample treatment conditions. This review discussed the DART principles, including devices, ionization mechanisms, and operation parameters. Typical spectra detected by DART-MS were exhibite...
Source: Mass Spectrometry Reviews - August 20, 2023 Category: Molecular Biology Authors: Yang Wang Shuying Liu Source Type: research
Quantification of modified nucleotides and nucleosides by isotope dilution mass spectrometry
Mass Spectrom Rev. 2023 Aug 19. doi: 10.1002/mas.21865. Online ahead of print.ABSTRACTEpigenetic modifications are closely related to certain disorders of the organism, including the development of tumors. One of the main epigenetic modifications is the methylation of DNA cytosines, 5-methyl-2'-deoxycycytidine. Furthermore, 5-mdC can be oxidized to form three new modifications, 5-(hydroxymethyl)-2'-deoxycytidine, 5-formyl-2'-deoxycytidine, and 5-carboxy-2'-deoxycytidine. The coupling of liquid chromatography with tandem mass spectrometry has been widely used for the total determination of methylated DNA cytosines in sample...
Source: Mass Spectrometry Reviews - August 19, 2023 Category: Molecular Biology Authors: Juan M Marchante-Gay ón Jes ús Nicolás Carcelén Hel í Potes Rodríguez Daniela Pineda-Cevallos Laura Rodas S ánchez Adriana Gonz ález-Gago Pablo Rodr íguez-González Jose I Garc ía Alonso Source Type: research
An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis
Mass Spectrom Rev. 2023 Aug 16. doi: 10.1002/mas.21864. Online ahead of print.ABSTRACTLysosomal storage disorders (LSDs) are a type of inherited metabolic disorders in which biomolecules, accumulate as a specific substrate in lysosomes due to specific individual enzyme deficiencies. Despite the fact that LSDs are incurable, various approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, or gene therapy are now available. Therefore, a timely diagnosis is a critical initial step in patient treatment. The-state-of-the-art in LSD diagnostic uses, in the first stage, enzymatic activity determi...
Source: Mass Spectrometry Reviews - August 16, 2023 Category: Molecular Biology Authors: Laura Darie-Ion Br înduşa Alina Petre Source Type: research
An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis
Mass Spectrom Rev. 2023 Aug 16. doi: 10.1002/mas.21864. Online ahead of print.ABSTRACTLysosomal storage disorders (LSDs) are a type of inherited metabolic disorders in which biomolecules, accumulate as a specific substrate in lysosomes due to specific individual enzyme deficiencies. Despite the fact that LSDs are incurable, various approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, or gene therapy are now available. Therefore, a timely diagnosis is a critical initial step in patient treatment. The-state-of-the-art in LSD diagnostic uses, in the first stage, enzymatic activity determi...
Source: Mass Spectrometry Reviews - August 16, 2023 Category: Molecular Biology Authors: Laura Darie-Ion Br înduşa Alina Petre Source Type: research
An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis
Mass Spectrom Rev. 2023 Aug 16. doi: 10.1002/mas.21864. Online ahead of print.ABSTRACTLysosomal storage disorders (LSDs) are a type of inherited metabolic disorders in which biomolecules, accumulate as a specific substrate in lysosomes due to specific individual enzyme deficiencies. Despite the fact that LSDs are incurable, various approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, or gene therapy are now available. Therefore, a timely diagnosis is a critical initial step in patient treatment. The-state-of-the-art in LSD diagnostic uses, in the first stage, enzymatic activity determi...
Source: Mass Spectrometry Reviews - August 16, 2023 Category: Molecular Biology Authors: Laura Darie-Ion Br înduşa Alina Petre Source Type: research
