Clinical characteristics and manometric findings of esophageal achalasia-a systematic review regarding differences among three subtypes
J Smooth Muscle Res. 2023;59:14-27. doi: 10.1540/jsmr.59.14.ABSTRACTEsophageal achalasia is classified into three subtypes according to manometric findings. Since several factors, including clinical characteristics and treatment response, have been reported to differ among the subtypes, the underlying pathogenesis may also differ. However, a comprehensive understanding regarding the differences is still lacking. We therefore performed a systematic review of the differences among the three subtypes of achalasia to clarify the current level of comprehension. In terms of clinical features, type III, which is the least frequen...
Source: Journal of Smooth Muscle Research - March 22, 2023 Category: Research Authors: Ryo Katsumata Noriaki Manabe Hiroyuki Sakae Kenta Hamada Maki Ayaki Takahisa Murao Minoru Fujita Tomoari Kamada Hirofumi Kawamoto Ken Haruma Source Type: research
Interstitial cells of Cajal in gastrointestinal inflammatory diseases
J Smooth Muscle Res. 2023;59:1-13. doi: 10.1540/jsmr.59.1.ABSTRACTThe gastrointestinal (GI) tract is a vital organ that digests food, absorbs nutrients, and excretes waste. Normal GI motility is the basis for these functions. The interstitial cells of Cajal (ICC) in the GI muscularis layer promote GI motility together with the enteric nervous system and smooth muscle cells. Since GI motility results from complex coordination of these heterogeneous cells, failure of any one of them can lead to GI dysmotility. Knowledge about ICC in physiological conditions has accumulated in recent decades, while the pathophysiology of ICC ...
Source: Journal of Smooth Muscle Research - February 15, 2023 Category: Research Authors: Noriyuki Kaji Masatoshi Hori Source Type: research
