Re-examination of therapeutic management of muscular dystrophies using a vascular smooth muscle-centered approach
We describe the possible mechanisms of action by which this BRMG helps in alleviating the symptoms of DMD by targeting smooth muscle dystrophin, in addition to its advantages over other therapeutic modalities, as well as how it can serve as a valuable adjunct to existing therapies. We suggest that using BRMG adjuncts that target smooth muscle dystrophin would be a potential therapeutic approach that prolongs the lifespan and extends the duration of ambulation from the onset of DMD. Further studies are needed to validate this hypothesis.PMID:37673649 | DOI:10.1540/jsmr.59.67 (Source: Journal of Smooth Muscle Research)
Source: Journal of Smooth Muscle Research - September 6, 2023 Category: Research Authors: Senthilkumar Preethy Naoki Yamamoto Shiro Osaza Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Masaru Iwasaki Samuel Jk Abraham Source Type: research
Direct active Fyn-paxillin interaction regulates vascular smooth muscle cell migration
J Smooth Muscle Res. 2023;59:58-66. doi: 10.1540/jsmr.59.58.ABSTRACTVascular smooth muscle cell (VSMC) migration plays an important role in cardiovascular diseases, including atherosclerotic plaque formation and restenosis after vascular intervention. The mechanisms involved in VSMC migration are complex and have not been fully elucidated. Recently, we discovered a novel interaction, direct binding of active Fyn-paxillin at focal adhesions, which plays an important role in actin stress fiber formation and migration in VSMCs. In this review, we highlight paxillin as an intermediate signaling molecule that mediates actin str...
Source: Journal of Smooth Muscle Research - July 12, 2023 Category: Research Authors: Ying Zhang Hiroko Kishi Sei Kobayashi Source Type: research
