Sex differences in the central regulation of colorectal motility in response to noxious stimuli
J Smooth Muscle Res. 2023;59:28-33. doi: 10.1540/jsmr.59.28.ABSTRACTDistinct sex differences in the prevalence and symptoms of abnormal bowel habits in patients with irritable bowel syndrome (IBS) have been reported. We have elucidated the sex differences in the regulation of colorectal motility via the central nervous system. Noxious stimuli in the colorectum of anesthetized male rats enhance colorectal motility by activating monoaminergic neurons in descending pain inhibitory pathways from the brainstem to the lumbosacral spinal cord. These monoaminergic neurons release serotonin and dopamine into the lumbosacral spinal ...
Source: Journal of Smooth Muscle Research - April 26, 2023 Category: Research Authors: Kazuhiro Horii Tomoya Sawamura Natsufu Yuki Takahiko Shiina Yasutake Shimizu Source Type: research
Clinical characteristics and manometric findings of esophageal achalasia-a systematic review regarding differences among three subtypes
J Smooth Muscle Res. 2023;59:14-27. doi: 10.1540/jsmr.59.14.ABSTRACTEsophageal achalasia is classified into three subtypes according to manometric findings. Since several factors, including clinical characteristics and treatment response, have been reported to differ among the subtypes, the underlying pathogenesis may also differ. However, a comprehensive understanding regarding the differences is still lacking. We therefore performed a systematic review of the differences among the three subtypes of achalasia to clarify the current level of comprehension. In terms of clinical features, type III, which is the least frequen...
Source: Journal of Smooth Muscle Research - March 22, 2023 Category: Research Authors: Ryo Katsumata Noriaki Manabe Hiroyuki Sakae Kenta Hamada Maki Ayaki Takahisa Murao Minoru Fujita Tomoari Kamada Hirofumi Kawamoto Ken Haruma Source Type: research
