The critical role of muscularis macrophages in modulating the enteric nervous system function and gastrointestinal motility
J Smooth Muscle Res. 2024;60:1-9. doi: 10.1540/jsmr.60.1.ABSTRACTMacrophages are the originators of inflammatory compounds, phagocytic purifiers in their local environment, and wound healing protectors in oxidative environments. They are molded by the tissue milieu they inhabit, with gastrointestinal (GI) muscularis macrophages (MMs) being a prime example. MMs are located in the muscular layer of the GI tract and contribute to muscle repair and maintenance of GI motility. MMs are often in close proximity to the enteric nervous system, specifically near the enteric neurons and interstitial cells of Cajal (ICCs). Consequentl...
Source: Journal of Smooth Muscle Research - March 10, 2024 Category: Research Authors: Egan L Choi Negar Taheri Yuebo Zhang Kenjiro Matsumoto Yujiro Hayashi Source Type: research
