Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Connectivity patterns of the core resting-state networks associated with apathy in late-life depression
CONCLUSION: Our findings indicate that apathy in LLD is consistently associated with changes in both intra-RSN and inter-RSN connectivity of brain regions implicated in goal-oriented behaviours. These results corroborate previous findings of altered functional RSN connectivity in severe LLD.PMID:37914222 | PMC:PMC10620011 | DOI:10.1503/jpn.230008 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2023 Category: Psychiatry Authors: Jean-Charles Roy Thomas Desmidt S ├ębastien Dam Iris Mirea-Grivel Louise Weyl Elise Bannier Laurent Barantin Dominique Drapier Jean-Marie Batail Renaud David Julie Coloigner Gabriel H Robert Source Type: research

Beyond verbal fluency in the verbal fluency task: semantic clustering as a predictor of remission in individuals at clinical high risk for psychosis
CONCLUSION: A verbal fluency task measure that more specifically represents semantic processing may be a better neurocognitive predictive marker for remission in CHR individuals than conventional verbal fluency measures. Our results provide an explanation for heterogeneous reports on whether verbal fluency can predict prognosis in CHR individuals and suggest that semantic processing is a putative cognitive predictor of their prognosis.PMID:37914223 | PMC:PMC10620004 | DOI:10.1503/jpn.230074 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2023 Category: Psychiatry Authors: Eugenie Choe Minji Ha Sunah Choi Sunghyun Park Moonyoung Jang Minah Kim Jun Soo Kwon Source Type: research

Connectivity patterns of the core resting-state networks associated with apathy in late-life depression
CONCLUSION: Our findings indicate that apathy in LLD is consistently associated with changes in both intra-RSN and inter-RSN connectivity of brain regions implicated in goal-oriented behaviours. These results corroborate previous findings of altered functional RSN connectivity in severe LLD.PMID:37914222 | PMC:PMC10620011 | DOI:10.1503/jpn.230008 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2023 Category: Psychiatry Authors: Jean-Charles Roy Thomas Desmidt S ├ębastien Dam Iris Mirea-Grivel Louise Weyl Elise Bannier Laurent Barantin Dominique Drapier Jean-Marie Batail Renaud David Julie Coloigner Gabriel H Robert Source Type: research

Beyond verbal fluency in the verbal fluency task: semantic clustering as a predictor of remission in individuals at clinical high risk for psychosis
CONCLUSION: A verbal fluency task measure that more specifically represents semantic processing may be a better neurocognitive predictive marker for remission in CHR individuals than conventional verbal fluency measures. Our results provide an explanation for heterogeneous reports on whether verbal fluency can predict prognosis in CHR individuals and suggest that semantic processing is a putative cognitive predictor of their prognosis.PMID:37914223 | PMC:PMC10620004 | DOI:10.1503/jpn.230074 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2023 Category: Psychiatry Authors: Eugenie Choe Minji Ha Sunah Choi Sunghyun Park Moonyoung Jang Minah Kim Jun Soo Kwon Source Type: research

Connectivity patterns of the core resting-state networks associated with apathy in late-life depression
CONCLUSION: Our findings indicate that apathy in LLD is consistently associated with changes in both intra-RSN and inter-RSN connectivity of brain regions implicated in goal-oriented behaviours. These results corroborate previous findings of altered functional RSN connectivity in severe LLD.PMID:37914222 | PMC:PMC10620011 | DOI:10.1503/jpn.230008 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2023 Category: Psychiatry Authors: Jean-Charles Roy Thomas Desmidt S ├ębastien Dam Iris Mirea-Grivel Louise Weyl Elise Bannier Laurent Barantin Dominique Drapier Jean-Marie Batail Renaud David Julie Coloigner Gabriel H Robert Source Type: research

Beyond verbal fluency in the verbal fluency task: semantic clustering as a predictor of remission in individuals at clinical high risk for psychosis
CONCLUSION: A verbal fluency task measure that more specifically represents semantic processing may be a better neurocognitive predictive marker for remission in CHR individuals than conventional verbal fluency measures. Our results provide an explanation for heterogeneous reports on whether verbal fluency can predict prognosis in CHR individuals and suggest that semantic processing is a putative cognitive predictor of their prognosis.PMID:37914223 | PMC:PMC10620004 | DOI:10.1503/jpn.230074 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2023 Category: Psychiatry Authors: Eugenie Choe Minji Ha Sunah Choi Sunghyun Park Moonyoung Jang Minah Kim Jun Soo Kwon Source Type: research