Peter M. Milner, 1919 –2018
Peter M. Milner, 1919–2018 J Psychiatry Neurosci. 2018 Nov 01;43(6):428-429 Authors: White NMW PMID: 30375838 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Tic-related obsessive –compulsive disorder
Tic-related obsessive–compulsive disorder J Psychiatry Neurosci. 2018 Nov 01;43(6):431-432 Authors: Pringsheim TP, Piacentini JP PMID: 30375839 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The perils of being too stable: mood regulation in bipolar disorder
Authors: Ortiz A, Alda M PMID: 30371048 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Low white-matter integrity between the left thalamus and inferior frontal gyrus in patients with insomnia disorder
Conclusion: The insomnia group showed decreased integrity in the left thalamus–pars triangularis tracts, and integrity was correlated with cognition and daytime sleepiness. These results may imply that insomnia is characterized by disintegration of the white-matter tract between the left thalamus and inferior frontal gyrus. PMID: 30371992 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide
Conclusion: Our results suggest that alterations of cytokines may be associated with the pathophysiology of depressed suicide and there may be an imbalance between pro- and anti-inflammatory cytokines in people who die by suicide. The causes of these increases in the brain of people who die by suicide, therefore, need to be investigated further. PMID: 30371993 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A negative association between brainstem pontine grey-matter volume, well-being and resilience in healthy twins
Conclusion: Associations with altered grey matter of the pontine nuclei suggest that basic sensory processes, such as arousal, startle, memory consolidation and/or emotional conditioning, may have a role in well-being and resilience. PMID: 30372012 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis
Conclusion: Structural grey-matter abnormalities in patients with bipolar disorder and bipolar disorder type I were mainly in the prefrontal cortex and insula. Patients' mood state might affect grey-matter alterations. Abnormalities in regional grey-matter volume could be correlated with patients' specific demographic and clinical features. PMID: 30354038 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Apathy alters emotional arousal in chronic schizophrenia.
CONCLUSION: Taken together, these results suggest that apathy in schizophrenia could impair tonic activity during positive emotions. Treatments aimed at enhancing positive emotions may help alleviate apathy in schizophrenia. PMID: 30277457 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 3, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

GABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study.
CONCLUSION: Our findings suggest that TSPO expression is negatively associated with GABA+ levels in the prefrontal cortex, independent of disease status. PMID: 30255837 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 27, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Cerebral blood flow in striatal regions is associated with apathy in patients with schizophrenia.
CONCLUSION: The main finding of this study was a specific association between increased striatal rCBF and the negative symptom dimension of apathy. Our results further support the separate assessment of apathy and diminished expression when investigating the neural basis of negative symptoms. The ASL technique can provide a direct and quantitative approach to investigating the role of rCBF changes in the pathophysiology of negative symptoms. PMID: 30246686 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study.
CONCLUSION: The results of the present study demonstrate changes during pharmacotherapy in the manifestation of affect, interpersonal behaviour and interpersonal perception in the daily lives of people with social anxiety disorder. Given the importance of interpersonal processes to social anxiety disorder, these results may guide future research seeking to clarify mechanisms of action for serotonergic medications. PMID: 30246687 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics.
CONCLUSION: Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder. PMID: 30246688 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Lifetime major depression and grey-matter volume
Conclusion: Major depressive disorder was associated with persistent volume reductions in the deep nuclei and insula and with enlargements in visual cortex subregions; alterations varied according to age of onset and genotype. PMID: 30226714 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 20, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up.
Authors: Kim SJ, Roh D, Jung HH, Chang WS, Kim CH, Chang JW Abstract BACKGROUND: Recently, a new thermal lesioning approach using magnetic resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years. METHODS: Eleven patients with trea...
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Managing disruptive behaviour in autism-spectrum disorder with guanfacine.
Authors: Propper L PMID: 30125242 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review.
CONCLUSION: Stability of the DMN, FPN and SN may reflect a state of remission. Further, DMN hypoconnectivity may reflect a positive history of psychosis in patients with bipolar disorder compared with controls, highlighting a potentially different neural phenotype of psychosis in people with bipolar disorder. Resting-state functional connectivity changes between the amygdala, prefrontal cortex and cingulate cortex may reflect a neural correlate of subthreshold symptoms experienced in bipolar disorder euthymia, the trait-based pathophysiology of bipolar disorder and/or a compensatory mechanism to maintain a state of euthymi...
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia.
CONCLUSION: The loss of CHRM1+ pyramidal cells in the cortex of people with schizophrenia may underpin derangements in the cholinergic regulation of GABAergic activity in cortical layer III and in cortical/subcortical communication via pyramidal cells in layer V. PMID: 30125244 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neurocognitive, emotional and neuroendocrine correlates of exposure to sexual assault in women.
CONCLUSION: Dysfunctions in the dorsal anterior cingulate cortex and the cerebellum may represent early functional brain modifications that alter higher cognitive processes when emotional material is involved. PMID: 30125245 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Who should be "controls" in studies on the neurobiology of psychiatric disorders?
Who should be "controls" in studies on the neurobiology of psychiatric disorders? J Psychiatry Neurosci. 2018 Aug;43(5):292-297 Authors: Boksa P, Joober R PMID: 30125246 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

White matter network alterations in patients with depersonalization/derealization disorder.
CONCLUSION: In patients with DPD, the structural connectivity between brain regions crucial for multimodal integration and emotion regulation may be altered. Aberrations in fibre tract communication seem to be not solely a secondary effect of local grey matter volume loss, but may present a primary pathophysiology in patients with DPD. PMID: 30125247 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

ER β agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy.
CONCLUSION: These findings suggest that ERβ alternative splicing and altered responses in the regulatory system for serotonin may mediate the antidepressant efficacy of ET associated with the timing of therapy initiation. It is likely that ERβ-specific ligands would be effective estrogen-based antidepressants late after the onset of menopause. PMID: 30106359 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 16, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Head motion: the dirty little secret of neuroimaging in psychiatry.
Authors: Makowski C, Lepage M, Evans AC Abstract Psychiatry is at a crossroads when choosing final samples for analysis of neuroimaging data. Many patient populations exhibit significantly increased motion in the scanner compared with healthy controls, suggesting that more patients would need to be excluded to obtain a clean sample. However, this need is often overshadowed by the extensive amount of time and effort required to recruit these valuable and uncommon samples. This commentary sheds light on the impact of motion on imaging studies, drawing examples from psychiatric patient samples to better understand how...
Source: Journal of Psychiatry and Neuroscience - August 16, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Performance monitoring and post-error adjustments in adults with attention-deficit/hyperactivity disorder: an EEG analysis.
CONCLUSION: Based on previous reports of post-error behavioural alterations in childhood samples, we conclude that people with ADHD develop compensatory strategies across the lifespan that lead to inconspicuous post-error behaviour in adulthood. Neurophysiologically, however, subtle alterations remain, indicating a perseverance of at least some frontal lobe deficits in people with ADHD who are partially medicated, particularly with respect to action-monitoring and post-error adaptation. PMID: 30062995 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - August 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A review of functional neurological symptom disorder etiology and the integrated etiological summary model.
Authors: Fobian AD, Elliott L Abstract Functional neurological symptom disorder (FNSD) is characterized by neurological symptoms that are unexplained by other traditional neurological or medical conditions. Both physicians and patients have limited understanding of FNSD, which is often explained as a physical manifestation of psychological distress. Recently, diagnostic criteria have shifted from requiring a preceding stressor to relying on positive symptoms. Given this shift, we have provided a review of the etiology of FNSD. Predisposing factors include trauma or psychiatric symptoms, somatic symptoms, illness ex...
Source: Journal of Psychiatry and Neuroscience - August 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disorders.
CONCLUSION: Four psychoradiological patterns of altered small-world properties are proposed. The analysis of altered small-world properties may provide novel insights into the pathophysiological mechanisms underlying psychiatric disorders from a connectomic perspective. In future connectome studies, the global network measures of both segregation and integration should be calculated to fully evaluate altered small-world properties in patients with a particular disease. PMID: 29952747 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review.
CONCLUSION: Stability of the DMN, FPN and SN may reflect a state of remission. Further, DMN hypoconnectivity may reflect a positive history of psychosis in patients with bipolar disorder compared with controls, highlighting a potentially different neural phenotype of psychosis in people with bipolar disorder. Resting-state functional connectivity changes between the amygdala, prefrontal cortex and cingulate cortex may reflect a neural correlate of subthreshold symptoms experienced in bipolar disorder euthymia, the trait-based pathophysiology of bipolar disorder and/or a compensatory mechanism to maintain a state of euthymi...
Source: Journal of Psychiatry and Neuroscience - June 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Are people with psychiatric disorders violent?
Authors: Leyton M PMID: 29947604 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review.
Authors: Soler J, Fañanás L, Parellada M, Krebs MO, Rouleau GA, Fatjó-Vilas M Abstract Scaffolding proteins represent an evolutionary solution to controlling the specificity of information transfer in intracellular networks. They are highly concentrated in complexes located in specific subcellular locations. One of these complexes is the postsynaptic density of the excitatory synapses. There, scaffolding proteins regulate various processes related to synaptic plasticity, such as glutamate receptor trafficking and signalling, and dendritic structure and function. Most scaffolding proteins can be...
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Examining cognition across the bipolar/schizophrenia diagnostic spectrum.
Authors: Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, Jones IR, Walters JTR Abstract BACKGROUND: Cognitive impairments are well-established features of schizophrenia, but there is ongoing debate about the nature and degree of cognitive impairment in patients with schizoaffective disorder and bipolar disorder. We hypothesized that there is a spectrum of increasing impairment from bipolar disorder to schizoaffective disorder bipolar type, to schizoaffective disorder depressive type and schizophrenia. METHODS: We compared performance on the Measurement and Treatment Research to Improve Cognitio...
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Effects of extended-release naltrexone on the brain response to drug-related stimuli in patients with opioid use disorder.
CONCLUSION: Extended-release naltrexone reduces the NAcc and mOFC cue reactivity in patients with OUD. This effect is specific to opioid-related stimuli in the mOFC only. The reduction in neural response to opioid-related stimuli is more robust in patients with greater decline in withdrawal severity. Our results support the clinical utility of mesocorticolimbic cue reactivity in monitoring the XR-NTX treatment outcomes and highlight the link between opioid withdrawal symptomatology and neural opioid cue reactivity. PMID: 29947607 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Correction: Enhanced corticobulbar excitability in chronic smokers during visual exposure to cigarette smoking cues.
Authors: PMID: 29947608 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Abnormal dynamic functional connectivity of amygdalar subregions in untreated patients with first-episode major depressive disorder.
Authors: Qiu L, Xia M, Cheng B, Yuan L, Kuang W, Bi F, Ai H, Gu Z, Lui S, Huang X, He Y, Gong Q Abstract BACKGROUND: Accumulating evidence supports the concept of the amygdala as a complex of structurally and functionally heterogeneous nuclei rather than as a single homogeneous structure. However, changes in resting-state functional connectivity in amygdalar subregions have not been investigated in major depressive disorder (MDD). Here, we explored whether amygdalar subregions - including the laterobasal, centromedial (CM) and superficial (SF) areas - exhibited distinct disruption patterns for different dynamic fun...
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The maternal brain in women with a history of early-life maltreatment: an imagination-based fMRI study of conflictual versus pleasant interactions with children.
CONCLUSION: Results suggest that for mothers with early-life maltreatment, conflictual interactions with their child may be more salient and behaviourally relevant than pleasant interactions, and that their salience network is poorly modulated by the brain regions involved in mentalizing processes. This activation pattern offers new insights into the mechanisms behind the intergenerational effects of maltreatment and into options for reducing these effects. PMID: 29947610 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Social anxiety disorder in schizophrenia: a neglected, yet potentially important comorbidity.
Authors: Roy MA, Demers MF, Achim AM PMID: 29947611 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 28, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A negative association between brainstem pontine grey-matter volume, well-being and resilience in healthy twins.
CONCLUSION: Associations with altered grey matter of the pontine nuclei suggest that basic sensory processes, such as arousal, startle, memory consolidation and/or emotional conditioning, may have a role in well-being and resilience. PMID: 29924721 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 23, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Low white-matter integrity between the left thalamus and inferior frontal gyrus in patients with insomnia disorder.
CONCLUSION: The insomnia group showed decreased integrity in the left thalamus-pars triangularis tracts, and integrity was correlated with cognition and daytime sleepiness. These results may imply that insomnia is characterized by disintegration of the white matter tract between the left thalamus and inferior frontal gyrus. PMID: 29894286 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 14, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide.
CONCLUSION: Our results suggest that alterations of cytokines may be associated with the pathophysiology of depressed suicide and there may be an imbalance between pro- and anti-inflammatory cytokines in people who die by suicide. The causes of these increases in the brain of people who die by suicide, therefore, need to be investigated further. PMID: 29889658 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 13, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

White matter network alterations in patients with depersonalization/derealization disorder.
CONCLUSION: In patients with DPD, the structural connectivity between brain regions crucial for multimodal integration and emotion regulation may be altered. Aberrations in fibre tract communication seem to be not solely a secondary effect of local grey matter volume loss, but may present a primary pathophysiology in patients with DPD. PMID: 29877178 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 8, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia.
CONCLUSION: The loss of CHRM1+ pyramidal cells in the cortex of people with schizophrenia may underpin derangements in the cholinergic regulation of GABAergic activity in cortical layer III and in cortical/subcortical communication via pyramidal cells in layer V. PMID: 29848411 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review.
Authors: Soler J, Fañanás L, Parellada M, Krebs MO, Rouleau GA, Fatjó-Vilas M Abstract Scaffolding proteins represent an evolutionary solution to controlling the specificity of information transfer in intracellular networks. They are highly concentrated in complexes located in specific subcellular locations. One of these complexes is the postsynaptic density of the excitatory synapses. There, scaffolding proteins regulate various processes related to synaptic plasticity, such as glutamate receptor trafficking and signalling, and dendritic structure and function. Most scaffolding proteins can be...
Source: Journal of Psychiatry and Neuroscience - May 31, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The maternal brain in women with a history of early-life maltreatment: an imagination-based fMRI study of conflictual versus pleasant interactions with children.
CONCLUSIONS: Results suggest that for mothers with early-life maltreatment, conflictual interactions with their child may be more salient and behaviourally relevant than pleasant interactions, and that their salience network is poorly modulated by the brain regions involved in mentalizing processes. This activation pattern offers new insights into the mechanisms behind the intergenerational effects of maltreatment and into options for reducing these effects. PMID: 29767624 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 18, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up.
Authors: Kim SJ, Roh D, Jung HH, Chang WS, Kim CH, Chang JW Abstract BACKGROUND: Recently, a new thermal lesioning approach using magnetic-resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years. METHODS: Eleven patients with trea...
Source: Journal of Psychiatry and Neuroscience - May 4, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Are people with psychiatric disorders violent?
Authors: Leyton M PMID: 29688170 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Drug coverage in Canada: gaps and opportunities.
Authors: Clement F, Memedovich KA PMID: 29688870 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Altered cortical thickness and attentional deficits in adolescent girls and women with bulimia nervosa.
CONCLUSION: Structural abnormalities in the frontoparietal and posterior cingulate regions comprising circuits that support control and attentional processes should be investigated as potential contributors to the maintenance of bulimia nervosa and useful targets for novel interventions. PMID: 29688871 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neural correlates of emotional action control in anger-prone women with borderline personality disorder.
CONCLUSION: The results indicate reduced lateral prefrontal-amygdala communication during emotional action control in anger-prone women with BPD. The findings provide a possible neural mechanism underlying difficulties with controlling emotional impulses in patients with BPD. PMID: 29688872 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Assessing the marks of change: how psychotherapy alters the brain structure in women with borderline personality disorder.
CONCLUSION: We found that DBT increased grey matter volume of brain regions that are critically implicated in emotion regulation and higher-order functions, such as mentalizing. The role of the angular gyrus for treatment response may reside in its cross-modal integrative function. These findings enhance our understanding of psychotherapy mechanisms of change and may foster the development of neurobiologically informed therapeutic interventions. PMID: 29688873 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A putative electrophysiological biomarker of auditory sensory memory encoding is sensitive to pharmacological alterations of excitatory/inhibitory balance in male macaque monkeys.
CONCLUSION: The N1 dynamic range may be a marker of altered E/I balance. Reduced N1 dynamic range in individuals with schizophrenia may indicate that the auditory cortex is in an excitation-deficient or inhibition-dominant state. This may be the result of an incomplete compensation for a primary deficit in excitatory drive. PMID: 29688874 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.
CONCLUSION: We found decreased serum pyridoxal levels in patients with schizophrenia in this observational study. However, we failed to obtain data supporting a causal relationship between pyridoxal levels and schizophrenia risk using the MR approach. PMID: 29688875 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neuroanatomical phenotypes in mental illness: identifying convergent and divergent cortical phenotypes across autism, ADHD and schizophrenia.
CONCLUSION: These findings suggest that common deficits across neuropsychiatric disorders cannot simply be characterized as arising out of local changes in cortical grey matter, but rather as entities of both local and systemic alterations targeting brain networks. PMID: 29688876 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 26, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research