Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research

Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial
CONCLUSION: These findings suggest a potential neural mechanism by which ToM psychotherapy exerts a beneficial effect on early-onset schizophrenia via strengthening the coordination capacity of the insula in brain structural networks, which may provide a clinically translatable biomarker for monitoring or predicting responses to ToM psychotherapy.Clinical trial registration: NCT05577338; ClinicalTrials.gov.PMID:37935475 | PMC:PMC10635708 | DOI:10.1503/jpn.230049 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Siyu Liu Hui Zhong Yinfeng Qian Huanhuan Cai Yan-Bin Jia Jiajia Zhu Source Type: research

Altered amygdalar emotion space in borderline personality disorder normalizes following dialectical behaviour therapy
CONCLUSION: Our findings suggest a more refined role for the amygdala in the pathological processing of perceived emotions and may provide new diagnostic and prognostic imaging-based markers of emotion dysregulation and personality disorders.Clinical trial registration: DRKS00019821, German Clinical Trials Register (Deutsches Register Klinischer Studien).PMID:37935476 | PMC:PMC10635707 | DOI:10.1503/jpn.230085 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Seth M Levine Katharina Merz Daniel Keeser Julia I Kunz Barbara B Barton Matthias A Reinhard Andrea Jobst Frank Padberg Corinne Neukel Sabine C Herpertz Katja Bertsch Richard Musil Source Type: research

Disrupted functional connectivity associated with cognitive impairment in generalized anxiety disorder (GAD) and comorbid GAD and depression: a follow-up fMRI study
CONCLUSION: Patients with GAD with or without comorbid depression exhibited shared and distinct abnormal VMHC patterns, which might be linked to their cognitive deficits. These patterns have the potential to serve as prognostic biomarkers for GAD.Clinical trial registration: ClinicalTrials.gov NCT03894085.PMID:37935477 | PMC:PMC10635709 | DOI:10.1503/jpn.230091 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 7, 2023 Category: Psychiatry Authors: Yiding Han Haohao Yan Xiaoxiao Shan Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo Source Type: research