Cardamonin mitigates kidney injury by modulating inflammation, oxidative stress, and apoptotic signaling in rats subjected to renal ischemia and reperfusion
J Med Life. 2023 Dec;16(12):1852-1856. doi: 10.25122/jml-2023-0093.ABSTRACTRenal ischemia-reperfusion injury (IRI) is a critical health concern that aggravates the pathophysiology of acute kidney injury (AKI), leading to high mortality rates in intensive care units. Cardamonin is a natural compound with anti-inflammatory and antioxidant properties. The current study aimed to evaluate the renoprotective impact of cardamonin against AKI induced by renal IRI. Male rats (n=5 per group) were divided into four groups: the sham group underwent anesthesia and abdominal incision only; the control group experienced bilateral renal a...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Haidar Hameed Ali Al-Sultany Murooj Altimimi Heider Qassam Najah Rayish Hadi Source Type: research
Assessment of dietary magnesium intake in the Eastern Province of Saudi Arabia
J Med Life. 2023 Dec;16(12):1789-1795. doi: 10.25122/jml-2023-0279.ABSTRACTMagnesium is an essential element and the most abundant intracellular cation after potassium. This cross-sectional study assessed the average dietary magnesium intake among residents of the Eastern Province of Saudi Arabia. Data was collected using a self-reported validated electronic questionnaire between April 2022 and July 2023. The first part of the survey included demographic data, and the second section comprised 33 items, including a semi-quantitative tool specifically designed to evaluate magnesium intake over the last three months. We inclu...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Mohsen Abualrahi Fatimah Habib Alhanabi Rahaf Saeed Alalloush Zainab Hashim Alsalman Waleed Ibrahim Albaker Mona Hmoud AlSheikh Fatimah Abdulwahed Almuzain Mohammed Taha Al-Hariri Source Type: research
In silico study, synthesis, and antineoplastic evaluation of thiazole-based sulfonamide derivatives and their silver complexes with expected carbonic anhydrase inhibitory activity
This study aimed to design, synthesize, and evaluate the cytotoxic activity of novel thiazole-sulfanilamide derivatives, specifically compounds M3, M4, and M5, through molecular docking and biological assays. The synthesis utilized essential chemical compounds, including sulfanilamide, chloro-acetyl chloride, thiourea, derivatives of benzaldehyde, and silver nitrate. The docking study was carried out using Molecular Operating Environment (MOE) software, and cytotoxic activity was predicted by MTT assay. The synthesized compounds demonstrated a reduction in the viability of cancer cells. Compound M5 had an IC50 of 18.53 µg...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Esraa Mahdi Naji Noor Hatef Naser Sahar Aqeel Hussein Source Type: research
Clinical and radiological outcomes of open reduction alone versus open reduction with pelvic osteotomy for developmental dysplasia of the hip in children over 1.5 years of age
J Med Life. 2023 Dec;16(12):1839-1843. doi: 10.25122/jml-2023-0212.ABSTRACTDevelopmental dysplasia of the hip (DDH) is commonly addressed through surgical intervention, usually performed in a specialized tertiary care facility. The purpose of this study was to evaluate the surgical outcomes in patients with DDH who had open reduction alone or in conjunction with bone surgery at our facility. We retrospectively reviewed the medical records of patients with DDH, categorizing them into two groups: Group OR underwent open reduction (OR) alone, and group ORBO underwent OR in conjunction with femoral or pelvic osteotomies. The m...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Saleh Aljanabi Wissam Saleh Hakim Source Type: research
Functional capacity in smoking patients after coronary artery bypass grafting surgery: a quasi-experimental study
J Med Life. 2023 Dec;16(12):1760-1768. doi: 10.25122/jml-2023-0282.ABSTRACTCoronary artery bypass grafting surgery (CABG) is an important approach to treating coronary heart disease. However, patients undergoing open heart surgery are at risk of postoperative complications. Cigarette smoking is one of the preoperative risk factors that may increase postoperative complications. Studies show that early mobilization intervention may reduce these complications and improve functional capacity, but the impact of smoking on early outcomes after CABG has been controversial for the past two decades. This quasi-experimental study ex...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mohammed Essa Alsubaiei Wadha Althukair Hind Almutairi Source Type: research
