Cardamonin mitigates kidney injury by modulating inflammation, oxidative stress, and apoptotic signaling in rats subjected to renal ischemia and reperfusion
J Med Life. 2023 Dec;16(12):1852-1856. doi: 10.25122/jml-2023-0093.ABSTRACTRenal ischemia-reperfusion injury (IRI) is a critical health concern that aggravates the pathophysiology of acute kidney injury (AKI), leading to high mortality rates in intensive care units. Cardamonin is a natural compound with anti-inflammatory and antioxidant properties. The current study aimed to evaluate the renoprotective impact of cardamonin against AKI induced by renal IRI. Male rats (n=5 per group) were divided into four groups: the sham group underwent anesthesia and abdominal incision only; the control group experienced bilateral renal a...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Haidar Hameed Ali Al-Sultany Murooj Altimimi Heider Qassam Najah Rayish Hadi Source Type: research
Assessment of dietary magnesium intake in the Eastern Province of Saudi Arabia
J Med Life. 2023 Dec;16(12):1789-1795. doi: 10.25122/jml-2023-0279.ABSTRACTMagnesium is an essential element and the most abundant intracellular cation after potassium. This cross-sectional study assessed the average dietary magnesium intake among residents of the Eastern Province of Saudi Arabia. Data was collected using a self-reported validated electronic questionnaire between April 2022 and July 2023. The first part of the survey included demographic data, and the second section comprised 33 items, including a semi-quantitative tool specifically designed to evaluate magnesium intake over the last three months. We inclu...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Mohsen Abualrahi Fatimah Habib Alhanabi Rahaf Saeed Alalloush Zainab Hashim Alsalman Waleed Ibrahim Albaker Mona Hmoud AlSheikh Fatimah Abdulwahed Almuzain Mohammed Taha Al-Hariri Source Type: research
In silico study, synthesis, and antineoplastic evaluation of thiazole-based sulfonamide derivatives and their silver complexes with expected carbonic anhydrase inhibitory activity
This study aimed to design, synthesize, and evaluate the cytotoxic activity of novel thiazole-sulfanilamide derivatives, specifically compounds M3, M4, and M5, through molecular docking and biological assays. The synthesis utilized essential chemical compounds, including sulfanilamide, chloro-acetyl chloride, thiourea, derivatives of benzaldehyde, and silver nitrate. The docking study was carried out using Molecular Operating Environment (MOE) software, and cytotoxic activity was predicted by MTT assay. The synthesized compounds demonstrated a reduction in the viability of cancer cells. Compound M5 had an IC50 of 18.53 µg...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Esraa Mahdi Naji Noor Hatef Naser Sahar Aqeel Hussein Source Type: research
Clinical and radiological outcomes of open reduction alone versus open reduction with pelvic osteotomy for developmental dysplasia of the hip in children over 1.5 years of age
J Med Life. 2023 Dec;16(12):1839-1843. doi: 10.25122/jml-2023-0212.ABSTRACTDevelopmental dysplasia of the hip (DDH) is commonly addressed through surgical intervention, usually performed in a specialized tertiary care facility. The purpose of this study was to evaluate the surgical outcomes in patients with DDH who had open reduction alone or in conjunction with bone surgery at our facility. We retrospectively reviewed the medical records of patients with DDH, categorizing them into two groups: Group OR underwent open reduction (OR) alone, and group ORBO underwent OR in conjunction with femoral or pelvic osteotomies. The m...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Saleh Aljanabi Wissam Saleh Hakim Source Type: research
Functional capacity in smoking patients after coronary artery bypass grafting surgery: a quasi-experimental study
J Med Life. 2023 Dec;16(12):1760-1768. doi: 10.25122/jml-2023-0282.ABSTRACTCoronary artery bypass grafting surgery (CABG) is an important approach to treating coronary heart disease. However, patients undergoing open heart surgery are at risk of postoperative complications. Cigarette smoking is one of the preoperative risk factors that may increase postoperative complications. Studies show that early mobilization intervention may reduce these complications and improve functional capacity, but the impact of smoking on early outcomes after CABG has been controversial for the past two decades. This quasi-experimental study ex...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mohammed Essa Alsubaiei Wadha Althukair Hind Almutairi Source Type: research
The impact of the COVID-19 pandemic on the mental health of patients diagnosed with inflammatory bowel diseases
In conclusion, the emergence of a novel viral pathogen represents a significant distress factor for patients with autoimmune diseases. Recognizing and comprehending these consequences enhances our understanding of the intricate interplay between physical and mental health and equips authorities with valuable insights to better manage future epidemics or viral outbreaks. This study underscores the importance of tailored support systems and strategies for patients with autoimmune diseases during global health crises.PMID:38585531 | PMC:PMC10994603 | DOI:10.25122/jml-2023-0475 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Oliviu-Florentiu Sarb Vitalie Vacaras Vladimir-Petru Filip Adriana-Daniela Sarb Roxana-Delia Zaharie Nicu Draghici Dafin-Fior Muresanu Alina-Ioana Tantau Source Type: research
Evaluating the renoprotective effects of omega-3-6-9 against cisplatin-induced nephrotoxicity in mice
This study explored the renoprotective potential of omega-3-6-9 when co-administered with cisplatin in a mice model. We divided adult mice into five groups: a control group received 0.5 ml of liquid paraffin; a cisplatin-only group; two groups were treated with low (50 mg/kg) and high (100 mg/kg) doses of omega-3-6-9 plus cisplatin; and a final group received vitamin E before cisplatin administration. The administration of omega-3-6-9 significantly decreased pro-inflammatory modulators and kidney function markers such as TNF-α, IL-1β, blood urea nitrogen, and creatinine, indicating potential renoprotective effects. Our r...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Saja Kareem Abd Alhusen Ali Faris Hasan Source Type: research
Assessment of manometric results following posterior pericervical repair or level I to III surgical procedures
This study aimed to evaluate the manometry results of patients before and after reconstructive surgery of the posterior compartment. This retrospective cohort study included 40 women with defecation disorders referred to the Imam Khomeini Hospital Complex, an academic center affiliated with Tehran University of Medical Sciences, Tehran, Iran, from 2020 to 2021. Data were collected through medical records and a checklist developed by the researcher before and after surgery. All analyses were performed using SPSS software (version 26), with significance at p<0.05. Forty women with a mean age of 49.47±9.66 years participa...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Maryam Deldar Pesikhani Reihane Sadat Hosseini Sanam Ghanbarpour Sanaz Ghashghaee Parivash Jelodarian Maryam Kazemi Tahereh Eftekhar Zinat Ghanbari Source Type: research
Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients
This study assessed the therapeutic response of chronic obstructive pulmonary disease (COPD) patients by measuring oxidative superoxide dismutase (SOD3), glutathione peroxidase 1 (GPX1), and inflammatory biomarkers such as tumor necrosis factor-alpha (TNF-α) and Interleukin-8 (IL-8) after sublingual administration of glutathione supplements. A cohort of 50 COPD individuals was involved and divided into two groups of 25 each. The first group received conventional therapy involving the administration of formoterol fumarate (12 µg inhaler) twice daily. The second group received the conventional treatment alongside sublingua...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ali Farag Wassan Abass Hyder Qassem Source Type: research
Valsalva purpura on the face of a 7-year-old child
This article overviews the relationship between the Valsalva maneuver, purpura, and similar cases.PMID:38585535 | PMC:PMC10994611 | DOI:10.25122/jml-2023-0447 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Alia Ali Galadari Moteb Al Otaibi Source Type: research
Exploring female medical students' knowledge, attitudes, practices, and perceptions related to breast cancer screening: a scoping review
J Med Life. 2023 Dec;16(12):1732-1739. doi: 10.25122/jml-2023-0412.ABSTRACTEarly detection measures for breast cancer, such as breast self-exams, clinical breast exams, and mammography, have considerable benefits in effectively reducing breast cancer-related mortality. As the incidence of breast cancer is steadily increasing, it is crucial to raise awareness on early detection. This scoping review assessed the current knowledge, attitudes, practices, and perceptions of breast cancer screening among female medical students. We used the six phases of Arksey and O'Malley's framework from the Joanna Briggs Institute Manual and...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mirela Tomic Maria-Lorena Vescan Marius-Ionu ţ Ungureanu Source Type: research
Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia
This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.PMID:38585537 | PMC:PMC10994609 | DOI:10.25122/jml-2023-0273 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mudathir Abdelshafea Abdelkareem Abakar Daralnaeem Hassan Ali Hamad Eman Faisal Hashim Mohamed Fad-Alla Omer Mahmoud Taha Mohamed Faki Abdellla Esmail Mohammed Idris Rouwida Omer Zeinab Osman Entesar Ahmed Gaffar Elhassan Mohamed Ahmed Abrahim-Holie Moham Source Type: research
Learning style preference and the academic achievements of medical students in an integrated curriculum
J Med Life. 2023 Dec;16(12):1802-1807. doi: 10.25122/jml-2023-0366.ABSTRACTUnderstanding how individuals learn best, known as learning style, is integral to optimizing educational outcomes. This analytical study was conducted among students in their fourth year who finalized their problem-based activities at the College of Medicine, University of Bisha, Saudi Arabia. The visual, aural, read/write, and kinesthetic (VARK) model was adopted to assess individual differences in learning preferences and their correlation with academic achievement in the problem-based learning (PBL)-dependent curriculum. The online self-administe...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Adel Mohamed Aboregela Source Type: research
Morphology and thickness of corneal endothelial cells in young Sudanese individuals with myopia
This study aimed to evaluate corneal endothelial cell morphology and central corneal thickness in young individuals with myopia. A prospective study was conducted at Al-Neelain University Eye Hospital between January 2019 and January 2020, including 160 patients with myopia (320 eyes). Data was gathered through clinical assessment of visual acuity, refractive error, and corneal endothelial cells. Results showed that 60% of participants with myopia were female, with a mean age of 21.99±2.8 years and a mean equivalent sphere of -3.19±2.67D. There was a significant difference in endothelial cell degeneration between myopia ...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Raghda Faisal Mutwaly Saif Hassan Alrasheed Abd Elaziz Mohamed Elmadina Sulaiman Aldakhil Source Type: research
Efficacy and safety of physical therapy in patients with stage III COPD during ambulatory rehabilitation
This study aimed to determine the efficacy of a combined physical therapy and pharmacological treatment for patients recovering from stage III COPD exacerbation. The efficacy of the rehabilitation program was assessed using anthropological parameters, physical condition, respiratory system function, and functional endurance capacity. Data were collected from 39 patients with stage III COPD who underwent the rehabilitation program. Physical and anthropometric assessments were conducted using the Quetelet Body Mass Index, the Pignet Index, and the Vital Capacity Index (VCI). The functional capacities of the cardiorespiratory...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Ulyana Kuz Svitlana Maliuvanchuk Roman Herych Petro Herych Source Type: research
