Rebastinib attenuates liver injury following cecal ligation and puncture in male mice
J Med Life. 2023 Nov;16(11):1678-1684. doi: 10.25122/jml-2023-0089.ABSTRACTSepsis remains a public health issue with high morbidity and mortality. Liver injury due to sepsis is associated with poor outcomes and an increased risk of death among septic patients. Rebastinib is a small molecule inhibiting the Tie2 receptor and vascular endothelial growth factor receptor-2 (VEGFR2). The current study aimed to reveal the potential protective impact of Rebastinib against sepsis-induced liver injury. Twenty-four adult male mice were allocated into four groups (six per group) as follows: Sham group was exposed to anesthesia and lap...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Aula Zaini Hayder Edrees Jawad Dhefaf Hameed Al-Mudhafar Najah Rayish Hadi Source Type: research
The effect of vitamin D on adolescents' primary dysmenorrhea
This study aimed to evaluate the effect of vitamin D on adolescents' primary dysmenorrhea and the relationship between Vit. D and adolescents' primary dysmenorrhea. Eighty-five adolescents were included in the current study. After a detailed evaluation, pelvic sonography was performed for all participants to rule out any pelvic pathology. Blood samples were collected to measure thyroid stimulating hormone (TSH), prolactin, glycosylated hemoglobin (HbA1C), and 25-hydroxyvitamin D (25[OH]D). Participants were administered vitamin D (50,000 IU weekly for five months), and their dysmenorrhea symptoms were evaluated before and ...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Ainur Donayeva Ainur Amanzholkyzy Ibrahim Abdelazim Meirambek Kurmangazin Zaituna Khamidullina Madina Kurmanalina Aigul Sumanova Zhanara Shabanbayeva Zhenisbek Baubekov Bauyrzhan Bissaliyev Gulnara Gubasheva Ihab Samaha Source Type: research
Epidemiological profile of hemophilia A in Karbala-Iraq
In this study, one-third of patients' presentations started in the first year of life. The most common type was severe hemophilia A (factor VIII activity < 1%). Consequently, more than half of the patients were treated with factor VIII concentrate. Four patients had hepatitis C, while HIV was confirmed in one patient. The epidemiological or clinical parameters of hemophilia A patients in Karbala seem similar to those in other cities in Iraq. By considering this preliminary data, further comprehensive studies for patients with hemophilia and associated complications in other provinces or cities in Iraq are highly suggest...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Inas Muayad Mohammed Ali Ashwaq Ali Hussein Israa Mustafa Salih Al-Musawi Sabeeha Sahib Hadi Hillawi Naus Salih Kadhim Abdulkareem Alaiwi Jasim Source Type: research
Mitigating healthcare worker risk during the COVID-19 pandemic - experience from a large tertiary maternity centre in the United Arab Emirates
This study describes the measures instituted at the largest maternity center in the United Arab Emirates during the pandemic to mitigate the risk of HCW contracting COVID-19, as well as the effectiveness of those measures. The incidence of COVID-19 amongst healthcare workers at the facility was compared to that in the general population over a 13-month period from February 2021 to February 2022. Data on population testing was obtained from the database maintained by the regional testing lab, while HCW testing data was obtained from the occupational health department at the hospital. The incidence of COVID-19 in HCWs and th...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Chokkiyil Ponnambath Hafis Ibrahim Ramza Al Chaer Elsin Thomas Stefan Weber Source Type: research
Association between < em > CNR1 < /em > gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM
J Med Life. 2023 Nov;16(11):1663-1669. doi: 10.25122/jml-2023-0181.ABSTRACTIn individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (CNR1) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between CNR1 rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Gen...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Raghda Hisham Aljorani Eman Saadi Saleh Khalaf Gata Al Mohammadawi Source Type: research
18 < sup > th < /sup > International Summer School of Neurology in conjunction with the 13 < sup > th < /sup > European Teaching Course on Neurorehabilitation
J Med Life. 2023 Nov;16(11):1582-1584. doi: 10.25122/jml-2023-1031.NO ABSTRACTPMID:38406791 | PMC:PMC10893578 | DOI:10.25122/jml-2023-1031 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Stefana-Andrada Dobran Alexandra Gherman Dafin Mure şanu Source Type: research
Neuroprotective effects of daidzein against ifosfamide-induced neurotoxicity in male rats: role of selected inflammatory and apoptotic markers
J Med Life. 2023 Nov;16(11):1628-1632. doi: 10.25122/jml-2023-0082.ABSTRACTIfosfamide (IFO), an alkylating chemotherapy agent, is known for its association with neurotoxicity and encephalopathy. This trial was designed to evaluate the protective action of daidzein (DZN) against IFO-induced neurotoxicity in male rats by determining the difference in certain inflammatory and apoptotic markers in the brain tissue of rats. Twenty-eight Wistar rats, weighing 120-150 g, were divided into four groups of seven rats: Group 1 (Control) received no treatment; Group 2 was orally administered DZN (100 mg/kg/day) for seven days; Group 3...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Hiba Zaki Hammoodi Nada Naji Al-Shawi Source Type: research
Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial
J Med Life. 2023 Nov;16(11):1615-1621. doi: 10.25122/jml-2023-0317.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most prevalent metabolic diseases during female reproductive life, often associated with insulin resistance and hyperprolactinemia. The efficacy of metformin and cabergoline for managing PCOS remains debated in the literature. This three-arm interventional study in Iraq assessed the effects of these drugs on body mass index (BMI), hormonal balance, and uterine artery blood flow in 75 women with PCOS and hyperprolactinemia. Participants were randomized into three groups: metformin (500 mg twice daily), c...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Inas Naser Hamad Sinaa Abdul Amir Kadhim Hayder Adnan Fawzi Shoroq Mohammed Al-Temimi Bassim Mohammad Asma Swadi Source Type: research
Effect of topical naringenin and its combination with minoxidil on enhancing hair growth in a mouse model
This study aimed to investigate the efficacy of naringenin (NAR) in reducing hair loss. Twenty-four adult Wistar Albino mice, weighing between 25-35 g and aged 6-7 weeks, were used in this research. The dorsal hair of these mice was meticulously clipped and stained subsequently. The mice were randomly divided into four groups (n=6 for each group): (1) negative control group, treated with absolute ethanol alcohol as the vehicle (2) minoxidil (5%) treated group; (3) 0.5% naringenin treated group, and (4) naringenin plus minoxidil treated group. The treatment groups had significantly higher total antioxidant capacity in tissu...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Nooralhuda Khayoon Sarmad Gany Najah Rayish Hadi Ahmed Al Mudhafar Source Type: research
The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review
J Med Life. 2023 Nov;16(11):1597-1605. doi: 10.25122/jml-2023-0248.ABSTRACTDysmenorrhea, affecting approximately 80% of adolescents, significantly impairs quality of life, disrupts sleep patterns, and induces mood changes. Furthermore, its economic impact is substantial, accounting for an estimated $200 billion in the United States and $4.2 million in Japan annually. This review aimed to identify the effects of vitamin D and calcium on primary dysmenorrhea. We conducted a comprehensive literature search across Web of Science, PubMed, Scopus, and Science Direct, focusing on studies published from 2010 to 2020. Keywords incl...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Ainur Donayeva Ainur Amanzholkyzy Ibrahim Abdelazim Samat Saparbayev Roza Nurgaliyeva Aiman Kaldybayeva Azhar Zhexenova Gulnara Gubasheva Dinmukhamed Ayaganov Ihab Samaha Source Type: research
Comparative analysis of lumbar quadratus lumborum block and epidural block for analgesia in uterine surgery at Dr. Soetomo Hospital, Surabaya
J Med Life. 2023 Nov;16(11):1707-1713. doi: 10.25122/jml-2023-0196.ABSTRACTOver 80% of surgical patients experience postoperative pain, which, if inadequately managed, can lead to complications, prolonged rehabilitation, chronic pain, and decreased quality of life. Epidural block and quadratus lumborum block are techniques commonly used for postoperative pain management. This comparative analytic study aimed to analyze the differences in the analgesic effects of quadratus lumborum block and epidural block in uterine surgery at Dr. Soetomo General Hospital. The outcomes assessed were the numerical rating score (NRS) as a pa...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Usamah Usamah Christrijogo Sumartono Mariza Fitriati Belindo Wirabuana Brahmana Askandar Tjokroprawiro Source Type: research
Regorafenib modulation of the angiopoietin/TIE2 axis in a mouse model of sepsis-induced lung injury
This study aimed to investigate the effects of regorafenib on lung injury in mice following the induction of sepsis. We divided mice into four groups (n=6 each): a sham group (undergoing laparotomy without cecal ligation and puncture [CLP]), a CLP group, a vehicle group, and a regorafenib-treated group (30 mg/kg IP, administered one hour before CLP). TNF-α, IL-1β, VEGF, MPO, caspase-11, and Ang-2 levels were significantly increased (p<0.05) in the CLP group compared to the sham group, while the regorafenib group showed significant reductions in these markers versus the CLP group (p< 0.05). In contrast, Ang-1 levels...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Mohammed Hamzah Ibadi Sahar Majeed Fadhaa Abdulameer Ghafil Najah Rayish Hadi Source Type: research
Effect of counselling intervention on stress and expressed emotions among family caregivers of children with autism
This study aimed to evaluate the effect of counseling intervention on stress and expressed emotions among family caregivers of children with autism. The research used a pre-post interventional design, to evaluate 40 family caregivers of children with autism. The interviewing questionnaire assessed socio-demographic data, expressed emotions, and parenting stress, revealing that 57.5% of the evaluated family caregivers had severe stress pre-counseling, compared to 25% post-counseling intervention. Additionally, 80% of them had elevated levels of expressed emotions pre-counseling, compared to 32.5% during the post-counseling ...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Hend Karem Mahmoud Ghada Mohammed Mourad Rania Abdel-Hamid Zaki Hoda Sayed Mohammed Source Type: research
Clinical and echocardiographic findings in patients with COVID-19 across different severity levels
J Med Life. 2023 Nov;16(11):1692-1700. doi: 10.25122/jml-2023-0206.ABSTRACTCardiovascular pathology can complicate the course of COVID-19. The study aimed to identify echocardiographic abnormalities and key prognostic factors influencing severe and fatal COVID-19 outcomes. This retrospective cohort study included clinical and echocardiogram data from 194 medical records of hospitalized patients with COVID-19: 100 moderate cases, 34 severe cases with favorable outcomes, and 60 severe cases with fatal outcomes. Severe patients with favorable outcomes had greater reductions in left ventricular systolic fraction of left ventri...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Ihor Hryzhak Oleksandra Pryshliak Taras Kobryn Sergiy Fedorov Oleksandr Boichuk Oleksandra Marynchak Viktoriia Kvasniuk Andrii Protsyk Ruslan Miziuk Andrii Kucher Marianna Simchych Lilia Hryzhak Mariia Kuravkin Source Type: research
Mindscapes of Neurorehabilitation: Insights from the European Congress on Neurorehabilitation 2023 - Part II
J Med Life. 2023 Nov;16(11):1579-1581. doi: 10.25122/jml-2023-1030.NO ABSTRACTPMID:38406778 | PMC:PMC10893577 | DOI:10.25122/jml-2023-1030 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Cristian Andriescu Alexandra Gherman Stefana-Andrada Dobran Dafin Muresanu Source Type: research
