Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
J Diet Suppl. 2024 Apr 1:1-18. doi: 10.1080/19390211.2024.2335573. Online ahead of print.ABSTRACTAcetaminophen (APAP) overdose is one of the most common causes of acute liver injury. The current standard-of-care treatment for APAP hepatotoxicity, N-acetyl-l-cysteine, is highly effective when administered early after overdose, but loses efficacy in later-presenting patients. As a result, there is interest in the identification of new treatments for APAP overdose patients. Natural products are a promising source of new treatments because many are purported to have hepatoprotective effects. In fact, a great deal of research h...
Source: Journal of Dietary Supplements - April 2, 2024 Category: Nutrition Authors: Alexander J Layman Scott M Alsbrook Igor K Koturbash Mitchell R McGill Source Type: research
Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity
CONCLUSION: Improvement in sleep disturbance was seen in both low and intermediate function phenotypes. L-methylfolate may be useful for improving sleep in patients with MTHFR polymorphism.PMID:38528721 | DOI:10.1080/19390211.2024.2327541 (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Alex S Carmon Russell J Amato Seema M Patel Shannon W Finks Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity
CONCLUSION: Improvement in sleep disturbance was seen in both low and intermediate function phenotypes. L-methylfolate may be useful for improving sleep in patients with MTHFR polymorphism.PMID:38528721 | DOI:10.1080/19390211.2024.2327541 (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Alex S Carmon Russell J Amato Seema M Patel Shannon W Finks Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity
CONCLUSION: Improvement in sleep disturbance was seen in both low and intermediate function phenotypes. L-methylfolate may be useful for improving sleep in patients with MTHFR polymorphism.PMID:38528721 | DOI:10.1080/19390211.2024.2327541 (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Alex S Carmon Russell J Amato Seema M Patel Shannon W Finks Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity
CONCLUSION: Improvement in sleep disturbance was seen in both low and intermediate function phenotypes. L-methylfolate may be useful for improving sleep in patients with MTHFR polymorphism.PMID:38528721 | DOI:10.1080/19390211.2024.2327541 (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Alex S Carmon Russell J Amato Seema M Patel Shannon W Finks Source Type: research
Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory stan...
Source: Journal of Dietary Supplements - March 26, 2024 Category: Nutrition Authors: Jordan Carty Victor J Navarro Source Type: research
