The Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid, and Vitamin K < sub > 1 < /sub > Modulate the Gut Microbiome: A Study Using an In Vitro Shime Model
In conclusion, our in vitro data further establish a role of PUFAs and vitamin K to modulate the gut microbiome with effects on the production of SCFAs and barrier integrity.PMID:37078491 | DOI:10.1080/19390211.2023.2198007 (Source: Journal of Dietary Supplements)
Source: Journal of Dietary Supplements - April 20, 2023 Category: Nutrition Authors: Ateequr Rehman Van Pham Nicole Seifert Nathalie Richard Wilbert Sybesma Robert E Steinert Source Type: research
Identification of Botanicals that Unmask β-Glucan from the Cell Surface of an Opportunistic Fungal Pathogen
In this study, a microplate-based screen was developed to identify β-glucan unmasking activity exhibited by botanicals. This screen measures the activity of a reporter gene in response to the transcriptional activation of NF-κB due to the interaction between β-glucan on the fungal cell surface and Dectin-1 present on host immune cells. In this proof-of-concept study, we screened a collection of botanicals (10 plants and some of their reported pure compound actives) used in traditional medicine for their antifungal properties. Several hits were identified in samples that unmasked β-glucan at sub-inhibitory concentration...
Source: Journal of Dietary Supplements - April 18, 2023 Category: Nutrition Authors: Jin Zhang Ameeta K Agarwal Qin Feng Siddharth K Tripathi Ikhlas A Khan Nirmal D Pugh Source Type: research
Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study
This study aimed to investigate the effects of 12-week consumption of highly bioavailable curcumin (150 mg/day of Theracurmin Super [TS-P1] or Theracurmin [CR-033P]) on common cold symptoms, immune function, and inflammatory markers. A randomized, double-blind, placebo-controlled study was conducted from November 2021 to May 2022 on 99 healthy Japanese adults. Using a computerized random number generator, each subject was randomly assigned to one of the following three groups: TS-P1, CR-033P, or placebo (n = 33 per group). For 12 weeks, each group consumed the four capsules that were given to them daily. The cumulative num...
Source: Journal of Dietary Supplements - March 17, 2023 Category: Nutrition Authors: Yoshitaka Kuwabara Akiko Hirose Hyunjin Lee Toshihiro Kakinuma Asami Baba Tsuyoshi Takara Source Type: research
