A Randomized, Double-Blind, Crossover Study to Investigate the Pharmacokinetics of Extended-Release Melatonin Compared to Immediate-Release Melatonin in Healthy Adults
J Diet Suppl. 2023 May 7:1-13. doi: 10.1080/19390211.2023.2206475. Online ahead of print.ABSTRACTExogenous melatonin can be helpful for treatment of some sleep disorders. However, immediate-release formulations are rapidly absorbed and cleared from the body making it difficult to provide coverage for an entire sleep period. Extended-release melatonin formulations can better mimic the naturally occurring melatonin profile and increase efficacy, but few studies have reported on their pharmacokinetics. To assess the pharmacokinetics of extended-release melatonin, we conducted a randomized, double-blind, crossover study of ext...
Source: Journal of Dietary Supplements - May 8, 2023 Category: Nutrition Authors: Jonathan G Mun Dan Wang Denise L Doerflein Fulk Mina Fakhary Scott J Gualco Ryan W Grant Susan Hazels Mitmesser Source Type: research
A Review of the Health-Promoting Properties of Spirulina with a Focus on athletes' Performance and Recovery
J Diet Suppl. 2023 May 4:1-32. doi: 10.1080/19390211.2023.2208663. Online ahead of print.ABSTRACTSpirulina species are photosynthetic and filamentous bacteria, commonly called 'blue-green microalgae'. Spirulina has a high nutrient content. It contains 60-70% protein with all essential amino acids present, and is rich in several vitamins, minerals, and bioactive compounds. Spirulina is also rich in essential fatty acids, and antioxidants. This rich nutritional content provides to Spirulina several health benefits including antioxidant, anti-inflammatory, immunomodulation, and insulin-sensitizing properties as well as positi...
Source: Journal of Dietary Supplements - May 5, 2023 Category: Nutrition Authors: Mehdi Chaouachi Sophie Vincent Carole Groussard Source Type: research
A Double-Blind, Randomized, Placebo-Controlled Pilot Study examining an Oxygen Nanobubble Beverage for 16.1-km Time Trial and Repeated Sprint Cycling Performance
J Diet Suppl. 2023 May 1:1-15. doi: 10.1080/19390211.2023.2203738. Online ahead of print.ABSTRACTThere is growing interest of ergogenic aids that deliver supplemental oxygen during exercise and recovery, however, breathing supplemental oxygen via specialist facemasks is often not feasible. Therefore, this study investigated the effect of an oxygen-nanobubble beverage during submaximal and repeated sprint cycling. In a double-blind, randomized, placebo-controlled study, 10 male cyclists (peak aerobic capacity, 56.9 ± 6.1 mL·kg-1·min-1; maximal aerobic power, 385 ± 25 W) completed submaximal or maximal exercise after con...
Source: Journal of Dietary Supplements - May 2, 2023 Category: Nutrition Authors: David G King Eleanor Stride Jeewaka Mendis William H Gurton Heather Macrae Louise Jones Julie Hunt Source Type: research
