High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research

Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders
In this study, to investigate the association of NOTCH1 in the pathogenesis of MTX-LPD, we evaluated protein expression of Notch1 in nuclei immunohistochemically in MTX-LPD cases [histologically DLBCL-type (n = 24) and classical Hodgkin lymphoma (CHL)-type (n = 24)] and de novo lymphoma cases [DLBCL (n = 19) and CHL (n = 15)]. The results showed that among MTX-LPD cases, the expression of Notch1 protein was significantly higher in the DLBCL type than in the CHL type (P < 0.001). In addition, among DLBCL morphology cases, expression of Notch1 tended to be higher in MTX-LPD than in the de novo group; however this differen...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Takeshi Okatani Midori Filiz Nishimura Yuria Egusa Sayako Yoshida Yoshito Nishimura Asami Nishikori Tadashi Yoshino Hidetaka Yamamoto Yasuharu Sato Source Type: research

High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R
J Clin Exp Hematop. 2024 Jan 28. doi: 10.3960/jslrt.23044. Online ahead of print.ABSTRACTPeritoneal lymphomatosis (PL) is a rare lymphoma-associated condition defined as the dissemination of lymphoma cells in the peritoneum. An 82-year-old man presented with abdominal pain, heartburn, and high fever. Radiological findings, including positron emission tomography-computed tomography (PET-CT), and gastrointestinal fiberscopy, showed diffuse thickening of the peritoneum, omentum, and mesentery; however, no lymphadenopathy, hepatosplenomegaly, or gastrointestinal lesions were observed. Under suspicion of peritonitis carcinomato...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - January 28, 2024 Category: Hematology Authors: Akihito Fujimi Yasuhiro Nagamachi Naofumi Yamauchi Naoki Onoyama Naotaka Hayasaka Teppei Matsuno Kazuhiko Koike Yoshiro Goto Kohji Ihara Junji Kato Takuji Nishisato Hiroshi Kawase Tomoyuki Yano Takayuki Kanaseki Shintaro Sugita Masayoshi Kobune Source Type: research